MPD: Project measures / variables set: Rusyn2 ALT

Project measures / variables set: Rusyn2 ALT_ctrl

ID, description, units	MPD:36112 ALT_ctrl alanine transaminase (serum ALT), control group [IU/L] trichloroethylene study
Measures	• time: 2h • 8h • 24h
Data set, strains	Rusyn2 inbred 17 strains sex: m age: 7wks
Procedure	metabolic panel
Comparison	timecourse but different cohorts
Ontology mappings	VT:0010487 response to xenobiotic stimulus trait VT:0001573 blood alanine transaminase amount MA:0002502 serum MP:0008872 abnormal physiological response to xenobiotic MP:0001573 abnormal circulating alanine transaminase level

Values Means Δ Means Z-scores

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Rusyn2 - alanine transaminase (serum ALT), control group

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
time	2	9111.9649	4555.9825	3.4518	0.0358
strain	15	67199.9255	4479.995	3.3943	0.0001
time:strain	30	38277.9437	1275.9315	0.9667	0.5249
Residuals	92	121427.9333	1319.8688

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Rusyn2	36112	metabolic panel	trichloroethylene	alanine transaminase (serum ALT), control group [IU/L] 2h after baseline ALT_2_ctrl	inbred	16	m	7wks
Rusyn2	36113	metabolic panel	trichloroethylene	alanine transaminase (serum ALT), control group [IU/L] 8h after baseline ALT_8_ctrl	inbred	17	m	7wks
Rusyn2	36114	metabolic panel	trichloroethylene	alanine transaminase (serum ALT), control group [IU/L] 24h after baseline ALT_24_ctrl	inbred	16	m	7wks