Phenotype measure:   HMDPpheno8   hydroxylithocholate

ID, description, units MPD:50306   hydroxylithocholate   6-beta-hydroxylithocholate (16h fast), relative abundance  
Data set, strains HMDPpheno8   HMDP   106 strains     sex: m     age: 16wks
Procedure metabolite quantification
Ontology mappings

  STRAIN COMPARISON PLOT
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HMDPpheno8 - 6-beta-hydroxylithocholate (16h fast), relative abundance



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested106 strains
Mean of the strain means59133   None
Median of the strain means46524   None
SD of the strain means± 41028
Coefficient of variation (CV)0.694
Min–max range of strain means9777   –   227761   None
Mean sample size per strain1.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 21 56199442803.6281 2676163943.0299 1.9853 0.0365
Residuals 34 45831072732.0312 1347972727.4127


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129X1/SvJ m 12212.0 0.0   1   0.0 0.0 12212.0, 12212.0 -1.14
A/J m 49527.0 31898.0   2   22555.0 0.644 26972.0, 72082.0 -0.23
AKR/J m 82700.0 0.0   1   0.0 0.0 82700.0, 82700.0 0.57
AXB10/PgnJ m 53232.0 0.0   1   0.0 0.0 53232.0, 53232.0 -0.14
AXB12/PgnJ m 48024.0 0.0   1   0.0 0.0 48024.0, 48024.0 -0.27
AXB13/PgnJ m 110627.0 0.0   1   0.0 0.0 110627.0, 110627.0 1.26
AXB15/PgnJ m 26106.0 0.0   1   0.0 0.0 26106.0, 26106.0 -0.8
AXB19a/PgnJ m 30237.0 0.0   1   0.0 0.0 30237.0, 30237.0 -0.7
AXB19b/PgnJ m 62639.0 30856.0   2   21818.0 0.493 40821.0, 84458.0 0.09
AXB19/PgnJ m 65096.0 0.0   1   0.0 0.0 65096.0, 65096.0 0.15
AXB1/PgnJ m 28749.0 0.0   1   0.0 0.0 28749.0, 28749.0 -0.74
AXB23/PgnJ m 44242.0 0.0   1   0.0 0.0 44242.0, 44242.0 -0.36
AXB24/PgnJ m 31597.0 1219.0   2   862.0 0.0386 30735.0, 32459.0 -0.67
AXB2/PgnJ m 46553.0 0.0   1   0.0 0.0 46553.0, 46553.0 -0.31
AXB4/PgnJ m 35654.0 0.0   1   0.0 0.0 35654.0, 35654.0 -0.57
AXB5/PgnJ m 166842.0 0.0   1   0.0 0.0 166842.0, 166842.0 2.63
AXB6/PgnJ m 63908.0 0.0   1   0.0 0.0 63908.0, 63908.0 0.12
AXB8/PgnJ m 112136.0 0.0   1   0.0 0.0 112136.0, 112136.0 1.29
BALB/cJ m 153265.0 72467.0   3 41839.0 0.473 73185.0, 214326.0 2.29
BTBR T+ Itpr3tf/J m 46767.0 0.0   1   0.0 0.0 46767.0, 46767.0 -0.3
BUB/BnJ m 35598.0 0.0   1   0.0 0.0 35598.0, 35598.0 -0.57
BXA11/PgnJ m 50350.0 0.0   1   0.0 0.0 50350.0, 50350.0 -0.21
BXA12/PgnJ m 22663.0 0.0   1   0.0 0.0 22663.0, 22663.0 -0.89
BXA13/PgnJ m 64814.0 0.0   1   0.0 0.0 64814.0, 64814.0 0.14
BXA14/PgnJ m 84014.0 0.0   1   0.0 0.0 84014.0, 84014.0 0.61
BXA16/PgnJ m 31509.0 12530.0   2   8860.0 0.398 22649.0, 40369.0 -0.67
BXA1/PgnJ m 26915.0 0.0   1   0.0 0.0 26915.0, 26915.0 -0.79
BXA24/PgnJ m 58767.0 0.0   1   0.0 0.0 58767.0, 58767.0 -0.01
BXA25/PgnJ m 43410.0 0.0   1   0.0 0.0 43410.0, 43410.0 -0.38
BXA26/PgnJ m 43967.0 0.0   1   0.0 0.0 43967.0, 43967.0 -0.37
BXA2/PgnJ m 65905.0 0.0   1   0.0 0.0 65905.0, 65905.0 0.17
BXA4/PgnJ m 22470.0 0.0   1   0.0 0.0 22470.0, 22470.0 -0.89
BXA7/PgnJ m 78083.0 0.0   1   0.0 0.0 78083.0, 78083.0 0.46
BXA8/PgnJ m 225377.0 0.0   1   0.0 0.0 225377.0, 225377.0 4.05
BXD11/TyJ m 116557.0 0.0   1   0.0 0.0 116557.0, 116557.0 1.4
BXD12/TyJ m 18976.0 0.0   1   0.0 0.0 18976.0, 18976.0 -0.98
BXD13/TyJ m 43905.0 0.0   1   0.0 0.0 43905.0, 43905.0 -0.37
BXD14/TyJ m 45622.0 0.0   1   0.0 0.0 45622.0, 45622.0 -0.33
BXD15/TyJ m 86351.0 0.0   1   0.0 0.0 86351.0, 86351.0 0.66
BXD18/TyJ m 9777.0 0.0   1   0.0 0.0 9777.0, 9777.0 -1.2
BXD19/TyJ m 107007.0 20069.0   2   14191.0 0.188 92816.0, 121198.0 1.17
BXD1/TyJ m 35974.0 0.0   1   0.0 0.0 35974.0, 35974.0 -0.56
BXD20/TyJ m 21124.0 0.0   1   0.0 0.0 21124.0, 21124.0 -0.93
BXD21/TyJ m 40354.0 0.0   1   0.0 0.0 40354.0, 40354.0 -0.46
BXD22/TyJ m 35941.0 0.0   1   0.0 0.0 35941.0, 35941.0 -0.57
BXD24/TyJ m 69845.0 0.0   1   0.0 0.0 69845.0, 69845.0 0.26
BXD24/TyJ-Cep290rd16/J m 101730.0 0.0   1   0.0 0.0 101730.0, 101730.0 1.04
BXD28/TyJ m 35714.0 14534.0   2   10277.0 0.407 25436.0, 45991.0 -0.57
BXD29-Tlr4lps-2J/J m 17609.0 0.0   1   0.0 0.0 17609.0, 17609.0 -1.01
BXD2/TyJ m 22041.0 0.0   1   0.0 0.0 22041.0, 22041.0 -0.9
BXD32/TyJ m 59247.0 0.0   1   0.0 0.0 59247.0, 59247.0 0.0
BXD33/TyJ m 40433.0 0.0   1   0.0 0.0 40433.0, 40433.0 -0.46
BXD34/TyJ m 112441.0 0.0   1   0.0 0.0 112441.0, 112441.0 1.3
BXD36/TyJ m 92706.0 0.0   1   0.0 0.0 92706.0, 92706.0 0.82
BXD38/TyJ m 162793.0 0.0   1   0.0 0.0 162793.0, 162793.0 2.53
BXD39/TyJ m 38312.0 0.0   1   0.0 0.0 38312.0, 38312.0 -0.51
BXD40/TyJ m 60151.0 0.0   1   0.0 0.0 60151.0, 60151.0 0.02
BXD42/TyJ m 30434.0 0.0   1   0.0 0.0 30434.0, 30434.0 -0.7
BXD5/TyJ m 38318.0 0.0   1   0.0 0.0 38318.0, 38318.0 -0.51
BXD6/TyJ m 51723.0 0.0   1   0.0 0.0 51723.0, 51723.0 -0.18
BXD8/TyJ m 23740.0 0.0   1   0.0 0.0 23740.0, 23740.0 -0.86
BXD9/TyJ m 32280.0 0.0   1   0.0 0.0 32280.0, 32280.0 -0.65
BXH10/TyJ m 16016.0 0.0   1   0.0 0.0 16016.0, 16016.0 -1.05
BXH19/TyJ m 42508.0 0.0   1   0.0 0.0 42508.0, 42508.0 -0.41
BXH20/KccJ m 30330.0 0.0   1   0.0 0.0 30330.0, 30330.0 -0.7
BXH22/KccJ m 22147.0 0.0   1   0.0 0.0 22147.0, 22147.0 -0.9
BXH2/TyJ m 34644.0 0.0   1   0.0 0.0 34644.0, 34644.0 -0.6
BXH4/TyJ m 34795.0 30633.0   2   21661.0 0.88 13134.0, 56456.0 -0.59
BXH6/TyJ m 63965.0 0.0   1   0.0 0.0 63965.0, 63965.0 0.12
BXH7/TyJ m 23455.0 0.0   1   0.0 0.0 23455.0, 23455.0 -0.87
BXH8/TyJ m 85575.0 0.0   1   0.0 0.0 85575.0, 85575.0 0.64
BXH9/TyJ m 140319.0 0.0   1   0.0 0.0 140319.0, 140319.0 1.98
C3H/HeJ m 76062.0 5776.0   2   4084.0 0.0759 71978.0, 80146.0 0.41
C57BL/6J m 100520.0 58995.0   5 26383.0 0.587 54741.0, 202342.0 1.01
C57L/J m 17736.0 0.0   1   0.0 0.0 17736.0, 17736.0 -1.01
C58/J m 46494.0 0.0   1   0.0 0.0 46494.0, 46494.0 -0.31
CAST/EiJ m 52606.0 0.0   1   0.0 0.0 52606.0, 52606.0 -0.16
CBA/J m 35785.0 0.0   1   0.0 0.0 35785.0, 35785.0 -0.57
CE/J m 54241.0 0.0   1   0.0 0.0 54241.0, 54241.0 -0.12
CXB11/HiAJ m 48885.0 26925.0   2   19039.0 0.551 29846.0, 67924.0 -0.25
CXB12/HiAJ m 72181.0 59642.0   2   42173.0 0.826 30008.0, 114354.0 0.32
CXB13/HiAJ m 62330.0 46950.0   3 27107.0 0.753 10270.0, 101462.0 0.08
CXB1/ByJ m 69183.0 22611.0   3 13055.0 0.327 45912.0, 91071.0 0.24
CXB2/ByJ m 35200.0 9419.0   3 5438.0 0.268 29136.0, 46051.0 -0.58
CXB3/ByJ m 56809.0 45095.0   2   31887.0 0.794 24922.0, 88696.0 -0.06
CXB4/ByJ m 83233.0 45986.0   2   32517.0 0.552 50716.0, 115750.0 0.59
CXB6/ByJ m 33791.0 21323.0   3 12311.0 0.631 14094.0, 56434.0 -0.62
CXB7/ByJ m 64723.0 43940.0   2   31070.0 0.679 33652.0, 95793.0 0.14
CXB8/HiAJ m 40637.0 5211.0   3 3008.0 0.128 37193.0, 46632.0 -0.45
CXB9/HiAJ m 26013.0 7029.0   3 4058.0 0.27 18289.0, 32034.0 -0.81
DBA/2J m 46237.0 14836.0   4 7418.0 0.321 26344.0, 57684.0 -0.31
FVB/NJ m 24896.0 0.0   1   0.0 0.0 24896.0, 24896.0 -0.83
I/LnJ m 50258.0 0.0   1   0.0 0.0 50258.0, 50258.0 -0.22
KK/HlJ m 45056.0 0.0   1   0.0 0.0 45056.0, 45056.0 -0.34
LG/J m 159023.0 0.0   1   0.0 0.0 159023.0, 159023.0 2.43
LP/J m 59577.0 0.0   1   0.0 0.0 59577.0, 59577.0 0.01
MA/MyJ m 227761.0 0.0   1   0.0 0.0 227761.0, 227761.0 4.11
NOD/ShiLtJ m 30446.0 0.0   1   0.0 0.0 30446.0, 30446.0 -0.7
NON/ShiLtJ m 110781.0 0.0   1   0.0 0.0 110781.0, 110781.0 1.26
NZW/LacJ m 48302.0 0.0   1   0.0 0.0 48302.0, 48302.0 -0.26
PL/J m 90326.0 0.0   1   0.0 0.0 90326.0, 90326.0 0.76
RIIIS/J m 19545.0 0.0   1   0.0 0.0 19545.0, 19545.0 -0.96
SEA/GnJ m 39177.0 0.0   1   0.0 0.0 39177.0, 39177.0 -0.49
SJL/J m 92833.0 0.0   1   0.0 0.0 92833.0, 92833.0 0.82
SM/J m 39184.0 0.0   1   0.0 0.0 39184.0, 39184.0 -0.49
SWR/J m 39406.0 0.0   1   0.0 0.0 39406.0, 39406.0 -0.48


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J m 49527.1 25961.2473 102286.7024 0.0
AXB19b/PgnJ m 62639.4 25961.2473 115399.0024 9879.7976
AXB24/PgnJ m 31596.9 25961.2473 84356.5024 0.0
BALB/cJ m 153264.9 21197.2697 196342.9349 110186.8651
BXA16/PgnJ m 31508.75 25961.2473 84268.3524 0.0
BXD19/TyJ m 107006.7 25961.2473 159766.3024 54247.0976
BXD28/TyJ m 35713.5 25961.2473 88473.1024 0.0
BXH4/TyJ m 34794.65 25961.2473 87554.2524 0.0
C3H/HeJ m 76062.3 25961.2473 128821.9024 23302.6976
C57BL/6J m 100520.14 16419.3345 133888.2424 67152.0376
CXB11/HiAJ m 48884.75 25961.2473 101644.3524 0.0
CXB12/HiAJ m 72181.15 25961.2473 124940.7524 19421.5476
CXB13/HiAJ m 62329.9667 21197.2697 105408.0016 19251.9317
CXB1/ByJ m 69182.5333 21197.2697 112260.5683 26104.4984
CXB2/ByJ m 35199.8333 21197.2697 78277.8683 0.0
CXB3/ByJ m 56809.35 25961.2473 109568.9524 4049.7476
CXB4/ByJ m 83233.0 25961.2473 135992.6024 30473.3976
CXB6/ByJ m 33790.9 21197.2697 76868.9349 0.0
CXB7/ByJ m 64722.7 25961.2473 117482.3024 11963.0976
CXB8/HiAJ m 40637.4667 21197.2697 83715.5016 0.0
CXB9/HiAJ m 26012.9 21197.2697 69090.9349 0.0
DBA/2J m 46237.075 18357.374 83543.7476 8930.4024




  GWAS USING LINEAR MIXED MODELS