MPD: Project measures / variables set: Rusyn2 ALT

Project measures / variables set: Rusyn2 ALT_tce

ID, description, units	MPD:36117 ALT_tce alanine transaminase (serum ALT), treated group [IU/L] trichloroethylene study
Measures	• time: 2h • 8h • 24h
Data set, strains	Rusyn2 inbred 17 strains sex: m age: 7wks
Procedure	metabolic panel
Comparison	timecourse but different cohorts
Ontology mappings	VT:0001573 blood alanine transaminase amount VT:0010487 response to xenobiotic stimulus trait MA:0002502 serum MP:0001573 abnormal circulating alanine transaminase level MP:0008872 abnormal physiological response to xenobiotic

Values Means Δ Means Z-scores

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Rusyn2 - alanine transaminase (serum ALT), treated group

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
time	2	625.9449	312.9725	0.2247	0.7992
time:strain	30	81183.4913	2706.1164	1.9427	0.0083
Residuals	94	130936.2383	1392.9387
strain	15	61445.41	4096.3607	2.9408	0.0007

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Rusyn2	36117	metabolic panel	trichloroethylene	alanine transaminase (serum ALT), treated group [IU/L] 2h after treatment ALT_2_tce	inbred	16	m	7wks
Rusyn2	36118	metabolic panel	trichloroethylene	alanine transaminase (serum ALT), treated group [IU/L] 8h after treatment ALT_8_tce	inbred	17	m	7wks
Rusyn2	36119	metabolic panel	trichloroethylene	alanine transaminase (serum ALT), treated group [IU/L] 24h after treatment ALT_24_tce	inbred	16	m	7wks