MPD: Phenotype measures mapped to VT:0010489, response to alcohol trait

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)	Year
Chesler6:4	Chesler6	rotarod	ethanol	latency difference, two trial post alcohol average minus pre trial latency to fall off rotarod [s] Rotarod_atax 27104	QTL population		both	9-34wks	N=186	2012

Chesler6:5	Chesler6	body temperature	ethanol	post alcohol minus pre alcohol body temperature [° C] Hypotherm 27105	QTL population		both	9-34wks	N=186	2012

Chesler6:6	Chesler6	behavior observation	ethanol	alcohol induced loss of righting reflex, latency to return of reflex [s] LORR 27106	QTL population		both	9-34wks	N=186	2012

Chesler6:7	Chesler6	alcohol quantification	ethanol	blood ethanol concentration at return of righting reflex [mg/mL] LORR_BEC 27107	QTL population		both	9-34wks	N=186	2012

Chesler6:9	Chesler6	rotarod	ethanol	latency to fall, first alcohol trial [s] RotaTest1 27109	QTL population		both	9-34wks	N=186	2012

Crabbe1:3	Crabbe1	balance beam	ethanol	missteps crossing 12.7mm wide balance beam [n] bal12 15403 dose (g/kg) control 1.0 1.2 1.4	inbred	8	both	8-16wks	N=3	2003

Crabbe1:4	Crabbe1	balance beam	ethanol	missteps crossing 15.8mm wide balance beam [n] bal15 15404 dose (g/kg): control 1.0 1.2 1.4	inbred	8	both	8-16wks	N=3	2003

Crabbe1:5	Crabbe1	balance beam	ethanol	missteps crossing 19.0 mm wide balance beam [n] bal19 15405 dose (g/kg) control 1.0 1.2 1.4	inbred	8	both	8-16wks	N=3	2003

Crabbe1:6	Crabbe1	grid test	ethanol	grid habituation, distance traveled [cm] grid_dist 15406 dose (g/kg): control 1.5 2.0 2.5	inbred	8	both	8-16wks	N=12	2003

Crabbe1:7	Crabbe1	grid test	ethanol	grid habituation, missteps per cm [n/cm] grid_ataxia 15407 dose (g/kg): control 1.5 2.0 2.5	inbred	8	both	8-16wks	N=12	2003

Crabbe3:10	Crabbe3	rotarod	ethanol	latency to fall, fixed speed 3 rpm rotarod [s] FS_3rpm_EtOH 15810 dose (g/kg): 1 2 3	inbred	9	both	9-17wks	N=4	2003

Crabbe3:15	Crabbe3	rotarod	ethanol	latency to fall, fixed speed 6 rpm rotarod [s] FS_6rpm_EtOH 15815 dose (g/kg) 1 2 3	inbred	9	both	9-17wks	N=3	2003

Crabbe3:20	Crabbe3	rotarod	ethanol	latency to fall, fixed speed 10 rpm rotarod [s] FS_10rpm_EtOH 15820 dose (g/kg): 1 2 3	inbred	9	both	9-17wks	N=3	2003

Crabbe3:40	Crabbe3	rotarod	ethanol	latency to-fall, accelerating rotarod, test day 1 20 rpm/min (ARR1) [s] ARR1_20rpm 15840 baseline ethanol difference	inbred	8	both	9-17wks	N=6	2003

Crabbe3:45	Crabbe3	rotarod	ethanol	latency to-fall, accelerating rotarod, test day 2 30 rpm/min (ARR1) [s] ARR1_30rpm 15845 baseline ethanol difference	inbred	8	both	9-17wks	N=6	2003

Crabbe3:55	Crabbe3	rotarod	ethanol	latency to fall, accelerating rotarod, 20 rpm/min (ARR2) [s] ARR2_20rpm 15855 baseline ethanol	inbred	21	both	9-17wks	N=9	2003

Crabbe3:57	Crabbe3	rotarod	ethanol	average latency to fall, accelerating rotarod, 20 rpm/min (ARR2), post-injection trials minus pre-injection trials (ETPOST - ETBASE) [s] ARR2_chg_20rpm 15857	inbred	21	both	9-17wks	N=9	2003

Crabbe4:1	Crabbe4	vertical wire mesh	ethanol	latency to fall from a vertical wire mesh grid 30 min post-injection [s] latency_screen30 19101	inbred	8	both	9-10wks	N=5	2003

Crabbe4:2	Crabbe4	dowel balance test	ethanol	latency to fall, 0 min post-injection [s] latency_dowel0 19102 9.5mm 15.8mm	inbred	8	both	12-16wks	N=4	2003

Crabbe4:3	Crabbe4	dowel balance test	ethanol	latency to fall, 30 min post-injection [s] latency_dowel30 19103 9.5mm 15.8mm	inbred	8	both	12-16wks	N=4	2003

Crabbe4:6	Crabbe4	grip strength	ethanol	grip strength test: peak force applied [g] grip 19106 baseline 30min after ethanol	inbred	21	both	7-12wks	N=6	2003

Crabbe4:8	Crabbe4	grip strength	ethanol	change in peak force applied (T0-T30) post-injection, grip strength test [g] gripEtOHeffect 19108	inbred	21	both	7-12wks	N=6	2003

Crabbe4:9	Crabbe4	grip strength	ethanol	percent change in average latency to fall post-injection, grip strength test [%] pct_gripchange 19109	inbred	21	both	7-12wks	N=6	2003

Crabbe5:1	Crabbe5	parallel rod floor test	ethanol	distance traveled, 1.6mm rod, 6mm space [cm] dist 19601 day1 control day2 control day3 ethanol	inbred	8	both	8-10wks	N=6	2005

Crabbe5:3	Crabbe5	parallel rod floor test	ethanol	motor incoordination, errors over distance traveled, 1.6mm rod, 6mm space [n/cm] err 19603 day1 control day2 control day3 ethanol	inbred	8	both	7-14wks	N=6	2005

Finn1:1	Finn1	bottle choice test	ethanol	dose of ethanol voluntarily consumed at 3% ethanol in water [g/kg] 3pct_EtOH 25601	inbred	22	both	8-9wks	N=8	2007

Finn1:2	Finn1	bottle choice test	ethanol	dose of ethanol voluntarily consumed at 6% ethanol in water [g/kg] 6pct_EtOH 25602	inbred	22	both	8-9wks	N=8	2007

Finn1:3	Finn1	bottle choice test	ethanol	dose of ethanol voluntarily consumed at 10% ethanol in water [g/kg] 10pct_EtOH 25603	inbred	22	both	8-9wks	N=8	2007

Finn1:5	Finn1	bottle choice test	ethanol	dose of ethanol voluntarily consumed at 3% ethanol in water with 0.2% saccharin [g/kg] 3pct_EtOHsach 25605	inbred	22	both	11-12wks	N=8	2007

Finn1:6	Finn1	bottle choice test	ethanol	dose of ethanol voluntarily consumed at 6% ethanol in water with 0.2% saccharin [g/kg] 6pct_EtOHsach 25606	inbred	22	both	11-12wks	N=8	2007

Finn1:7	Finn1	bottle choice test	ethanol	dose of ethanol voluntarily consumed at 10% ethanol in water with 0.2% saccharin [g/kg] 10pct_EtOHsach 25607	inbred	22	both	11-12wks	N=8	2007

Metten1:1	Metten1	open field test	ethanol	line crossings, 2.75 g/kg i.p. [n] line_doseA 16501 pre-injection 10min after injection 30min after	inbred	9	both	8-11wks	N=4	2004

Metten1:2	Metten1	open field test	ethanol	line crossings, 3.0 g/kg i.p. [n] line_doseB 16502 pre-injection 10min after injection 30min after	inbred	9	both	8-11wks	N=4	2004

Metten1:9	Metten1	behavior observation	ethanol	hindlimb splay, 2.75 g/kg i.p. [score] splay_doseA 16509 10min after injection 30min after	inbred	9	both	8-11wks	N=4	2004

Metten1:11	Metten1	behavior observation	ethanol	hindlimb splay, 3.0 g/kg i.p. [score] splay_doseB 16511 10min after injection 30min after	inbred	9	both	8-11wks	N=4	2004

Metten1:13	Metten1	behavior observation	ethanol	erratic gait, 2.75 g/kg i.p. [score] wobble_doseA 16513 10min after injection 30min after	inbred	9	both	8-11wks	N=4	2004

Metten1:15	Metten1	behavior observation	ethanol	erratic gait, 3.0 g/kg i.p. [score] wobble_doseB 16515 10min after injection 30min after	inbred	9	both	8-11wks	N=4	2004

Metten2:3	Metten2	behavior observation	ethanol	peak handling-induced convulsion (HIC) score [score] peak 19503 control ethanol ethanol normalized to controls	inbred	15	m	8-15wks	N=9	2005

Metten2:6	Metten2	behavior observation	ethanol	latency to first handling-induced convulsions score used to calculate peak ethanol [h] peak_latency 19506	inbred	15	m	8-15wks	N=11	2005

Metten2:7	Metten2	behavior observation	ethanol	withdrawal severity during 0-25h, area under curve of handling-induced convulsions scores [AUC] withdrawal_EtOH 19507	inbred	15	m	8-15wks	N=20	2005

Metten2:8	Metten2	behavior observation	ethanol	withdrawal severity during 0-25h, area under curve of handling-induced convulsions scores normalized to controls [AUC] withdrawal_EtOHadj 19508	inbred	15	m	8-15wks	N=11	2005

Rusyn5:1	Rusyn5	metabolic panel	high-fat diet and ethanol	serum alanine transaminase (ALT) [IU/L] ALT 43001 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:3	Rusyn5	metabolite quantification	high-fat diet and ethanol	homocysteine concentration (plasma) [nmol/mL] plasma_homocysteine 43003 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:5	Rusyn5	alcohol quantification	high-fat diet and ethanol	blood alcohol concentration (BAC) [mg/dL] BAC 43005 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:7	Rusyn5	alcohol quantification	high-fat diet and ethanol	urine alcohol concentration (UAC), daily average [mg/dL] avg_UAC 43007 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:9	Rusyn5	alcohol quantification	high-fat diet and ethanol	urine alcohol concentration (UAC), daily peak [mg/dL] peak_UAC 43009 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:11	Rusyn5	organ weights	high-fat diet and ethanol	liver weight as a percent of body weight [%] pctLW_BW 43011 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:13	Rusyn5	histopathology	high-fat diet and ethanol	liver steatosis (0-4) [score] steatosis 43013 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:15	Rusyn5	histopathology	high-fat diet and ethanol	liver inflammation (0-2) [score] inflammation 43015 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:17	Rusyn5	histopathology	high-fat diet and ethanol	liver necrosis (0-2) [score] necrosis 43017 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:19	Rusyn5	histopathology	high-fat diet and ethanol	total liver histopathology (0-8) [score] total_pathology 43019 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:21	Rusyn5	lipid profile	high-fat diet and ethanol	hepatic triglycerides (TG) [mg/g] liver_TG 43021 high-fat only high-fat and ethanol	inbred	6	m	8-14wks	N=3	2011

Rusyn5:23	Rusyn5	metabolite quantification	high-fat diet and ethanol	reduced liver glutathione (GSH) [nmol/mg] liver_GSH 43023 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:25	Rusyn5	metabolite quantification	high-fat diet and ethanol	oxidized liver glutathione (GSSG) [nmol/mg] liver_GSSG 43025 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:29	Rusyn5	metabolite quantification	high-fat diet and ethanol	ratio of reduced to oxidized liver glutathione [ratio] liver_GSHratio 43029 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:31	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver homocysteine [nmol/mg] liver_homocysteine 43031 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:33	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver S-adenosylhomocysteine (SAH) [nmol/mg] liver_SAH 43033 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:35	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver methionine [nmol/mg] liver_methionine 43035 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:37	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver S-adenosylmethionine (SAM) [nmol/mg] liver_SAM 43037 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:39	Rusyn5	metabolite quantification	high-fat diet and ethanol	ratio of liver SAM to SAH (SAM/SAH) [ratio] liver_SAM_SAH 43039 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:42	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver BHMT, protein expression relative to high-fat-only group [%] liver_BHMT_hfe 43042	inbred	14	m	8-14wks	N=3	2011

Rusyn5:44	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver DDIT3 (formerly CHOP), protein expression relative to high-fat-only group [%] liver_DDIT3_hfe 43044	inbred	14	m	8-14wks	N=3	2011

Rusyn5:46	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver HSPA5 (formerly GRP78), protein expression relative to high-fat-only group [%] liver_HSPA5_hfe 43046	inbred	14	m	8-14wks	N=3	2011

Rusyn5:48	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver SREBF1 (formerly NSREBP1), protein expression relative to high-fat-only group [%] liver_SREBF1_hfe 43048	inbred	14	m	8-14wks	N=3	2011

Rusyn5:50	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Acox1, mRNA abundance relative to high-fat-only group [%] liver_Acox1_hfe 43050	inbred	6	m	8-14wks	N=3	2011

Rusyn5:52	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Adipor2, mRNA abundance relative to high-fat-only group [%] liver_Adipor2_hfe 43052	inbred	6	m	8-14wks	N=3	2011

Rusyn5:54	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Ahcy, mRNA abundance relative to high-fat-only group [%] liver_Ahcy_hfe 43054	inbred	14	m	8-14wks	N=3	2011

Rusyn5:56	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Cbs, mRNA abundance relative to high-fat-only group [%] liver_Cbs_hfe 43056	inbred	14	m	8-14wks	N=3	2011

Rusyn5:58	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Cebpa, mRNA abundance relative to high-fat-only group [%] liver_Cebpa_hfe 43058	inbred	14	m	8-14wks	N=3	2011

Rusyn5:60	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Cth, mRNA abundance relative to high-fat-only group [%] liver_Cth_hfe 43060	inbred	14	m	8-14wks	N=3	2011

Rusyn5:62	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Ddit3 (formerly Chop), mRNA abundance relative to high-fat-only group [%] liver_Ddit3_hfe 43062	inbred	14	m	8-14wks	N=3	2011

Rusyn5:64	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Gnmt, mRNA abundance relative to high-fat-only group [%] liver_Gnmt_hfe 43064	inbred	14	m	8-14wks	N=3	2011

Rusyn5:66	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Mat1a, mRNA abundance relative to high-fat-only group [%] liver_Mat1a_hfe 43066	inbred	14	m	8-14wks	N=3	2011

Rusyn5:68	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Mthfr, mRNA abundance relative to high-fat-only group [%] liver_Mthfr_hfe 43068	inbred	14	m	8-14wks	N=3	2011

Rusyn5:70	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Mtr, mRNA abundance relative to high-fat-only group [%] liver_Mtr_hfe 43070	inbred	14	m	8-14wks	N=3	2011

Rusyn5:72	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Mttp, mRNA abundance relative to high-fat-only group [%] liver_Mttp_hfe 43072	inbred	6	m	8-14wks	N=3	2011

Rusyn5:74	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Srebf1, mRNA abundance relative to high-fat-only group [%] liver_Srebf1_hfe 43074	inbred	14	m	8-14wks	N=3	2011

Chesler6

rotarod

ethanol

latency difference, two trial post alcohol average minus pre trial latency to fall off rotarod [s] Rotarod_atax 27104

QTL population

both

9-34wks

N=186

2012

Chesler6

body temperature

ethanol

post alcohol minus pre alcohol body temperature [° C] Hypotherm 27105

QTL population

both

9-34wks

N=186

2012

Chesler6

behavior observation

ethanol

alcohol induced loss of righting reflex, latency to return of reflex [s] LORR 27106

QTL population

both

9-34wks

N=186

2012

Chesler6

alcohol quantification

ethanol

blood ethanol concentration at return of righting reflex [mg/mL] LORR_BEC 27107

QTL population

both

9-34wks

N=186

2012

Chesler6

rotarod

ethanol

latency to fall, first alcohol trial [s] RotaTest1 27109

QTL population

both

9-34wks

N=186

2012

Crabbe1

balance beam

ethanol

missteps crossing 12.7mm wide balance beam [n] bal12 15403 dose (g/kg) control 1.0 1.2 1.4

inbred

8

both

8-16wks

N=3

2003

Crabbe1

balance beam

ethanol

missteps crossing 15.8mm wide balance beam [n] bal15 15404 dose (g/kg): control 1.0 1.2 1.4

inbred

8

both

8-16wks

N=3

2003

Crabbe1

balance beam

ethanol

missteps crossing 19.0 mm wide balance beam [n] bal19 15405 dose (g/kg) control 1.0 1.2 1.4

inbred

8

both

8-16wks

N=3

2003

Crabbe1

grid test

ethanol

grid habituation, distance traveled [cm] grid_dist 15406 dose (g/kg): control 1.5 2.0 2.5

inbred

8

both

8-16wks

N=12

2003

Crabbe1

grid test

ethanol

grid habituation, missteps per cm [n/cm] grid_ataxia 15407 dose (g/kg): control 1.5 2.0 2.5

inbred

8

both

8-16wks

N=12

2003

Crabbe3

rotarod

ethanol

latency to fall, fixed speed 3 rpm rotarod [s] FS_3rpm_EtOH 15810 dose (g/kg): 1 2 3

inbred

9

both

9-17wks

N=4

2003

Crabbe3

rotarod

ethanol

latency to fall, fixed speed 6 rpm rotarod [s] FS_6rpm_EtOH 15815 dose (g/kg) 1 2 3

inbred

9

both

9-17wks

N=3

2003

Crabbe3

rotarod

ethanol

latency to fall, fixed speed 10 rpm rotarod [s] FS_10rpm_EtOH 15820 dose (g/kg): 1 2 3

inbred

9

both

9-17wks

N=3

2003

Crabbe3

rotarod

ethanol

latency to-fall, accelerating rotarod, test day 1 20 rpm/min (ARR1) [s] ARR1_20rpm 15840 baseline ethanol difference

inbred

8

both

9-17wks

N=6

2003

Crabbe3

rotarod

ethanol

latency to-fall, accelerating rotarod, test day 2 30 rpm/min (ARR1) [s] ARR1_30rpm 15845 baseline ethanol difference

inbred

8

both

9-17wks

N=6

2003

Crabbe3

rotarod

ethanol

latency to fall, accelerating rotarod, 20 rpm/min (ARR2) [s] ARR2_20rpm 15855 baseline ethanol

inbred

21

both

9-17wks

N=9

2003

Crabbe3

rotarod

ethanol

average latency to fall, accelerating rotarod, 20 rpm/min (ARR2), post-injection trials minus pre-injection trials (ETPOST - ETBASE) [s] ARR2_chg_20rpm 15857

inbred

21

both

9-17wks

N=9

2003

Crabbe4

vertical wire mesh

ethanol

latency to fall from a vertical wire mesh grid 30 min post-injection [s] latency_screen30 19101

inbred

8

both

9-10wks

N=5

2003

Crabbe4

dowel balance test

ethanol

latency to fall, 0 min post-injection [s] latency_dowel0 19102 9.5mm 15.8mm

inbred

8

both

12-16wks

N=4

2003

Crabbe4

dowel balance test

ethanol

latency to fall, 30 min post-injection [s] latency_dowel30 19103 9.5mm 15.8mm

inbred

8

both

12-16wks

N=4

2003

Crabbe4

grip strength

ethanol

grip strength test: peak force applied [g] grip 19106 baseline 30min after ethanol

inbred

21

both

7-12wks

N=6

2003

Crabbe4

grip strength

ethanol

change in peak force applied (T0-T30) post-injection, grip strength test [g] gripEtOHeffect 19108

inbred

21

both

7-12wks

N=6

2003

Crabbe4

grip strength

ethanol

percent change in average latency to fall post-injection, grip strength test [%] pct_gripchange 19109

inbred

21

both

7-12wks

N=6

2003

Crabbe5

parallel rod floor test

ethanol

distance traveled, 1.6mm rod, 6mm space [cm] dist 19601 day1 control day2 control day3 ethanol

inbred

8

both

8-10wks

N=6

2005

Crabbe5

parallel rod floor test

ethanol

motor incoordination, errors over distance traveled, 1.6mm rod, 6mm space [n/cm] err 19603 day1 control day2 control day3 ethanol

inbred

8

both

7-14wks

N=6

2005

Finn1

bottle choice test

ethanol

dose of ethanol voluntarily consumed at 3% ethanol in water [g/kg] 3pct_EtOH 25601

inbred

22

both

8-9wks

N=8

2007

Finn1

bottle choice test

ethanol

dose of ethanol voluntarily consumed at 6% ethanol in water [g/kg] 6pct_EtOH 25602

inbred

22

both

8-9wks

N=8

2007

Finn1

bottle choice test

ethanol

dose of ethanol voluntarily consumed at 10% ethanol in water [g/kg] 10pct_EtOH 25603

inbred

22

both

8-9wks

N=8

2007

Finn1

bottle choice test

ethanol

dose of ethanol voluntarily consumed at 3% ethanol in water with 0.2% saccharin [g/kg] 3pct_EtOHsach 25605

inbred

22

both

11-12wks

N=8

2007

Finn1

bottle choice test

ethanol

dose of ethanol voluntarily consumed at 6% ethanol in water with 0.2% saccharin [g/kg] 6pct_EtOHsach 25606

inbred

22

both

11-12wks

N=8

2007

Finn1

bottle choice test

ethanol

dose of ethanol voluntarily consumed at 10% ethanol in water with 0.2% saccharin [g/kg] 10pct_EtOHsach 25607

inbred

22

both

11-12wks

N=8

2007

Metten1

open field test

ethanol

line crossings, 2.75 g/kg i.p. [n] line_doseA 16501 pre-injection 10min after injection 30min after

inbred

9

both

8-11wks

N=4

2004

Metten1

open field test

ethanol

line crossings, 3.0 g/kg i.p. [n] line_doseB 16502 pre-injection 10min after injection 30min after

inbred

9

both

8-11wks

N=4

2004

Metten1

behavior observation

ethanol

hindlimb splay, 2.75 g/kg i.p. [score] splay_doseA 16509 10min after injection 30min after

inbred

9

both

8-11wks

N=4

2004

Metten1

behavior observation

ethanol

hindlimb splay, 3.0 g/kg i.p. [score] splay_doseB 16511 10min after injection 30min after

inbred

9

both

8-11wks

N=4

2004

Metten1

behavior observation

ethanol

erratic gait, 2.75 g/kg i.p. [score] wobble_doseA 16513 10min after injection 30min after

inbred

9

both

8-11wks

N=4

2004

Metten1

behavior observation

ethanol

erratic gait, 3.0 g/kg i.p. [score] wobble_doseB 16515 10min after injection 30min after

inbred

9

both

8-11wks

N=4

2004

Metten2

behavior observation

ethanol

peak handling-induced convulsion (HIC) score [score] peak 19503 control ethanol ethanol normalized to controls

inbred

15

m

8-15wks

N=9

2005

Metten2

behavior observation

ethanol

latency to first handling-induced convulsions score used to calculate peak ethanol [h] peak_latency 19506

inbred

15

m

8-15wks

N=11

2005

Metten2

behavior observation

ethanol

withdrawal severity during 0-25h, area under curve of handling-induced convulsions scores [AUC] withdrawal_EtOH 19507

inbred

15

m

8-15wks

N=20

2005

Metten2

behavior observation

ethanol

withdrawal severity during 0-25h, area under curve of handling-induced convulsions scores normalized to controls [AUC] withdrawal_EtOHadj 19508

inbred

15

m

8-15wks

N=11

2005

Rusyn5

metabolic panel

high-fat diet and ethanol

serum alanine transaminase (ALT) [IU/L] ALT 43001 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

homocysteine concentration (plasma) [nmol/mL] plasma_homocysteine 43003 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

alcohol quantification

high-fat diet and ethanol

blood alcohol concentration (BAC) [mg/dL] BAC 43005 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

alcohol quantification

high-fat diet and ethanol

urine alcohol concentration (UAC), daily average [mg/dL] avg_UAC 43007 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

alcohol quantification

high-fat diet and ethanol

urine alcohol concentration (UAC), daily peak [mg/dL] peak_UAC 43009 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

organ weights

high-fat diet and ethanol

liver weight as a percent of body weight [%] pctLW_BW 43011 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

histopathology

high-fat diet and ethanol

liver steatosis (0-4) [score] steatosis 43013 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

histopathology

high-fat diet and ethanol

liver inflammation (0-2) [score] inflammation 43015 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

histopathology

high-fat diet and ethanol

liver necrosis (0-2) [score] necrosis 43017 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

histopathology

high-fat diet and ethanol

total liver histopathology (0-8) [score] total_pathology 43019 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

lipid profile

high-fat diet and ethanol

hepatic triglycerides (TG) [mg/g] liver_TG 43021 high-fat only high-fat and ethanol

inbred

6

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

reduced liver glutathione (GSH) [nmol/mg] liver_GSH 43023 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

oxidized liver glutathione (GSSG) [nmol/mg] liver_GSSG 43025 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

ratio of reduced to oxidized liver glutathione [ratio] liver_GSHratio 43029 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

liver homocysteine [nmol/mg] liver_homocysteine 43031 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

liver S-adenosylhomocysteine (SAH) [nmol/mg] liver_SAH 43033 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

liver methionine [nmol/mg] liver_methionine 43035 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

liver S-adenosylmethionine (SAM) [nmol/mg] liver_SAM 43037 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

ratio of liver SAM to SAH (SAM/SAH) [ratio] liver_SAM_SAH 43039 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

liver BHMT, protein expression relative to high-fat-only group [%] liver_BHMT_hfe 43042

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

liver DDIT3 (formerly CHOP), protein expression relative to high-fat-only group [%] liver_DDIT3_hfe 43044

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

liver HSPA5 (formerly GRP78), protein expression relative to high-fat-only group [%] liver_HSPA5_hfe 43046

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

liver SREBF1 (formerly NSREBP1), protein expression relative to high-fat-only group [%] liver_SREBF1_hfe 43048

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Acox1, mRNA abundance relative to high-fat-only group [%] liver_Acox1_hfe 43050

inbred

6

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Adipor2, mRNA abundance relative to high-fat-only group [%] liver_Adipor2_hfe 43052

inbred

6

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Ahcy, mRNA abundance relative to high-fat-only group [%] liver_Ahcy_hfe 43054

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Cbs, mRNA abundance relative to high-fat-only group [%] liver_Cbs_hfe 43056

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Cebpa, mRNA abundance relative to high-fat-only group [%] liver_Cebpa_hfe 43058

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Cth, mRNA abundance relative to high-fat-only group [%] liver_Cth_hfe 43060

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Ddit3 (formerly Chop), mRNA abundance relative to high-fat-only group [%] liver_Ddit3_hfe 43062

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Gnmt, mRNA abundance relative to high-fat-only group [%] liver_Gnmt_hfe 43064

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Mat1a, mRNA abundance relative to high-fat-only group [%] liver_Mat1a_hfe 43066

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Mthfr, mRNA abundance relative to high-fat-only group [%] liver_Mthfr_hfe 43068

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Mtr, mRNA abundance relative to high-fat-only group [%] liver_Mtr_hfe 43070

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Mttp, mRNA abundance relative to high-fat-only group [%] liver_Mttp_hfe 43072

inbred

6

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Srebf1, mRNA abundance relative to high-fat-only group [%] liver_Srebf1_hfe 43074

inbred

14

m

8-14wks

N=3

2011

Filter Table Results