Phenotype measure:   Crabbe4   gripEtOHeffect

ID, description, units MPD:19108   gripEtOHeffect   change in peak force applied (T0-T30) post-injection, grip strength test   [g]
ethanol study
Data set, strains Crabbe4   inbred   21 strains     sex: both     age: 7-12wks
Procedure grip strength
Ontology mappings

  STRAIN COMPARISON PLOT
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Crabbe4 - change in peak force applied (T0-T30) post-injection, grip strength test



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested21 strains21 strains
Mean of the strain means37.3   g 56.4   g
Median of the strain means35.9   g 55.4   g
SD of the strain means± 16.1 ± 18.0
Coefficient of variation (CV)0.433 0.319
Min–max range of strain means13.8   –   62.5   g 26.1   –   95.8   g
Mean sample size per strain6.2   mice 5.5   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 23265.1581 23265.1581 42.7848 < 0.0001
strain 19 49333.9361 2596.523 4.775 < 0.0001
sex:strain 19 14053.6888 739.6678 1.3603 0.1506
Residuals 196 106579.2045 543.7715


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 41.0 8.63   6 3.52 0.211 29.3, 53.1 0.23
129S1/SvImJ m 95.8 26.2   6 10.7 0.273 69.1, 146.0 2.19
A/J f 32.6 12.1   6 4.94 0.37 20.2, 53.6 -0.29
A/J m 40.4 15.3   6 6.24 0.378 22.5, 61.4 -0.89
AKR/J f 35.9 13.2   6 5.4 0.368 24.0, 59.0 -0.09
AKR/J m 61.8 17.3   6 7.04 0.279 28.6, 73.6 0.3
BALB/cByJ f 60.2 26.6   6 10.8 0.441 24.9, 102.0 1.42
BALB/cByJ m 79.3 19.2   6 7.84 0.242 65.3, 108.0 1.27
BTBR T+ Itpr3tf/J f 62.2 34.6   2   24.4 0.555 37.8, 86.7 1.55
BTBR T+ Itpr3tf/J m 47.6 26.3   5 11.8 0.553 16.2, 81.1 -0.49
C3H/HeJ f 17.0 26.0   3 15.0 1.53 -12.3, 37.4 -1.26
C3H/HeJ m 55.4 32.2   6 13.2 0.582 15.4, 89.3 -0.06
C57BL/6J f 44.4 16.6   12 4.78 0.373 19.0, 80.6 0.44
C57BL/6J m 57.2 21.2   6 8.65 0.371 18.6, 76.8 0.04
C57L/J f 27.3 12.0   6 4.9 0.44 5.9, 40.2 -0.62
C57L/J m 67.3 35.3   6 14.4 0.524 5.3, 101.0 0.61
C58/J f 22.4 10.5   4 5.25 0.47 11.0, 36.4 -0.92
C58/J m 40.2 20.8   4 10.4 0.516 10.4, 56.6 -0.9
CAST/EiJ f 25.8 12.3   6 5.0 0.475 4.9, 36.2 -0.71
CAST/EiJ m 26.1 18.3   5 8.21 0.703 -0.4, 40.8 -1.68
DBA/2J f 35.5 16.3   12 4.7 0.458 21.4, 64.8 -0.11
DBA/2J m 57.4 9.68   6 3.95 0.169 42.7, 69.7 0.06
FVB/NJ f 36.5 41.8   6 17.0 1.14 -16.5, 111.0 -0.05
FVB/NJ m 55.0 24.9   6 10.2 0.452 30.1, 97.9 -0.08
MOLF/EiJ f 47.9 12.3   7 4.66 0.258 33.7, 63.8 0.66
MOLF/EiJ m 38.2 33.0   6 13.5 0.864 -20.8, 65.0 -1.01
NOD/ShiLtJ f 62.5 37.0   6 15.1 0.592 22.1, 125.0 1.56
NOD/ShiLtJ m 62.7 49.3   6 20.1 0.787 -0.8, 115.0 0.35
NZB/BlNJ f 61.5 12.0   6 4.9 0.195 43.4, 81.1 1.5
NZB/BlNJ m 81.9 20.5   5 9.17 0.251 59.8, 104.0 1.42
PERA/EiJ f 19.2 10.0   8 3.55 0.521 7.8, 36.0 -1.12
PERA/EiJ m 46.1 32.5   4 16.3 0.705 18.3, 91.0 -0.57
PL/J f 41.6 10.0   6 4.1 0.241 25.8, 53.6 0.27
PL/J m 64.6 0.0   1   0.0 0.0 64.6, 64.6 0.46
SJL/J f 13.8 14.8   6 6.04 1.07 -11.6, 29.1 -1.46
SJL/J m 47.6 28.0   5 12.5 0.588 14.7, 88.9 -0.49
SM/J f 54.4 8.52   6 3.48 0.157 41.3, 64.9 1.06
SM/J m 84.1 22.2   6 9.07 0.264 61.3, 123.0 1.54
SPRET/EiJ f 22.9 27.5   6 11.2 1.2 -4.8, 58.0 -0.89
SPRET/EiJ m 40.0 43.1   4 21.6 1.08 -17.8, 83.6 -0.91
SWR/J f 18.1 8.35   6 3.41 0.463 5.3, 26.7 -1.19
SWR/J m 35.9 24.8   6 10.1 0.69 9.8, 73.4 -1.14


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 40.95 9.5199 59.7246 22.1754
129S1/SvImJ m 95.8 9.5199 114.5746 77.0254
A/J f 32.65 9.5199 51.4246 13.8754
A/J m 40.4333 9.5199 59.2079 21.6587
AKR/J f 35.9167 9.5199 54.6913 17.1421
AKR/J m 61.8 9.5199 80.5746 43.0254
BALB/cByJ f 60.1833 9.5199 78.9579 41.4087
BALB/cByJ m 79.2833 9.5199 98.0579 60.5087
BTBR T+ Itpr3tf/J f 62.25 16.489 94.7686 29.7314
BTBR T+ Itpr3tf/J m 47.56 10.4285 68.1265 26.9935
C3H/HeJ f 17.0333 13.4632 43.5846 0.0
C3H/HeJ m 55.4167 9.5199 74.1913 36.6421
C57BL/6J f 44.4333 6.7316 57.709 31.1577
C57BL/6J m 57.1833 9.5199 75.9579 38.4087
C57L/J f 27.2833 9.5199 46.0579 8.5087
C57L/J m 67.3333 9.5199 86.1079 48.5587
C58/J f 22.35 11.6595 45.3441 0.0
C58/J m 40.2 11.6595 63.1941 17.2059
CAST/EiJ f 25.7833 9.5199 44.5579 7.0087
CAST/EiJ m 26.12 10.4285 46.6865 5.5535
DBA/2J f 35.525 6.7316 48.8006 22.2494
DBA/2J m 57.45 9.5199 76.2246 38.6754
FVB/NJ f 36.4833 9.5199 55.2579 17.7087
FVB/NJ m 55.0333 9.5199 73.8079 36.2587
MOLF/EiJ f 47.8714 8.8137 65.2533 30.4895
MOLF/EiJ m 38.1667 9.5199 56.9413 19.3921
NOD/ShiLtJ f 62.4667 9.5199 81.2413 43.6921
NOD/ShiLtJ m 62.6833 9.5199 81.4579 43.9087
NZB/BlNJ f 61.5167 9.5199 80.2913 42.7421
NZB/BlNJ m 81.88 10.4285 102.4465 61.3135
PERA/EiJ f 19.25 8.2445 35.5093 2.9907
PERA/EiJ m 46.125 11.6595 69.1191 23.1309
SJL/J f 13.8167 9.5199 32.5913 0.0
SJL/J m 47.62 10.4285 68.1865 27.0535
SM/J f 54.4333 9.5199 73.2079 35.6587
SM/J m 84.0667 9.5199 102.8413 65.2921
SPRET/EiJ f 22.8833 9.5199 41.6579 4.1087
SPRET/EiJ m 39.975 11.6595 62.9691 16.9809
SWR/J f 18.05 9.5199 36.8246 0.0
SWR/J m 35.95 9.5199 54.7246 17.1754


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 68.375 6.7316 81.6506 55.0994
A/J both 36.5417 6.7316 49.8173 23.266
AKR/J both 48.8583 6.7316 62.134 35.5827
BALB/cByJ both 69.7333 6.7316 83.009 56.4577
BTBR T+ Itpr3tf/J both 54.905 9.755 74.1432 35.6668
C3H/HeJ both 36.225 8.2445 52.4843 19.9657
C57BL/6J both 50.8083 5.8297 62.3054 39.3113
C57L/J both 47.3083 6.7316 60.584 34.0327
C58/J both 31.275 8.2445 47.5343 15.0157
CAST/EiJ both 25.9517 7.0601 39.8753 12.0281
DBA/2J both 46.4875 5.8297 57.9845 34.9905
FVB/NJ both 45.7583 6.7316 59.034 32.4827
MOLF/EiJ both 43.019 6.4867 55.8118 30.2263
NOD/ShiLtJ both 62.575 6.7316 75.8506 49.2994
NZB/BlNJ both 71.6983 7.0601 85.6219 57.7747
PERA/EiJ both 32.6875 7.1399 46.7684 18.6066
SJL/J both 30.7183 7.0601 44.6419 16.7947
SM/J both 69.25 6.7316 82.5256 55.9744
SPRET/EiJ both 31.4292 7.5261 46.2718 16.5865
SWR/J both 27.0 6.7316 40.2756 13.7244




  GWAS USING LINEAR MIXED MODELS