Crabbe4: Drug study: Measurement of ethanol sensitivity and intoxication using performances in the screen, dowel, and grip strength tests, in 21 inbred strains of mice (2003)

Crabbe JC, Cotnam CJ, Cameron AJ, Schlumbohm JP, Rhodes JS, Metten P, Wahlsten D. Strain differences in three measures of ethanol intoxication in mice: the screen, dowel and grip strength tests. Genes Brain Behav. 2003 Aug;2(4):201-13.   PubMed 12953786  


       
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Participants John C Crabbe       Oregon Health & Science University Portland, OR
Pamela Metten       Oregon Health & Science University Portland, OR
Douglas Wahlsten       University of Windsor Windsor, Ontario CANADA
With: Cotnam CJ, Cameron AJ, Schlumbohm JP, Rhodes JS
ContactJohn C Crabbe     crabbe@ohsu.edu
AcknowledgementsFunding provided by NIH AA10760, AA12714, AA07468; Department of Veterans Affairs; Natural Sciences and Engineering Research Council of Canada.

Acknowledgements: Best K, Kliethermes CL, Rustay NR, Yu C-H, Zuraw JM, Bobo M.
Project type Phenotype strain survey data set
MPD identifiersCrabbe4     MPD:191
Data changelog No updates/corrections.       Initial release date: 02/2010.
Formatted citation
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An investigation of the pharmacokinetic differences of ethanol intoxication. Blood ethanol concentration (BEC) levels were determined before and after ethanol administration. This project has a complex study design involving multiple cohorts, as described in the protocol workflow table.

Summary of procedures that were conducted
• dowel balance test Ethanol i.p. Latency to fall 0 min and 30 min post-injection, 2 widths.
• vertical wire mesh Latency to fall 30 min post-injection. Ethanol i.p.
• grip strength Baseline vs. 30 min after ethanol i.p.
• alcohol quantification Blood alcohol concentration after ethanol injection, several timepoints.
Mice: inbred   21 strains   ♀♂   age 9-17wks   8 cohorts

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Crabbe4 19101 vertical wire mesh ethanol latency to fall from a vertical wire mesh grid 30 min post-injection   [s]  latency_screen30 inbred 8 both 9-10wks N=5
    Crabbe4 19102 dowel balance test ethanol latency to fall 0 min post-injection   [s]     9.5mm    15.8mm inbred 8 both 12-16wks N=4
    Crabbe4 19103 dowel balance test ethanol latency to fall, 30 min post-injection   [s]     9.5mm    15.8mm inbred 8 both 12-16wks N=4
    Crabbe4 19106 grip strength ethanol grip strength test: peak force applied   [g]     baseline    30min after ethanol inbred 21 both 7-12wks N=6
    Crabbe4 19108 grip strength ethanol change in peak force applied (T0-T30) post-injection, grip strength test   [g]  gripEtOHeffect inbred 21 both 7-12wks N=6
    Crabbe4 19109 grip strength ethanol percent change in average latency to fall post-injection, grip strength test   [%]  pct_gripchange inbred 21 both 7-12wks N=6
    Crabbe4 19111 alcohol quantification ethanol blood ethanol concentration (BEC), 35 min post-injection, dowel (15.8 mm) test   [mg/mL]  BEC_dowel15_8 inbred 8 both 12-16wks N=3
    Crabbe4 19112 alcohol quantification ethanol blood ethanol concentration   [mg/mL]     time after ethanol:    30min    60min    105min    150min inbred 21 both 7-12wks N=6
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