Crabbe4: Drug study: Measurement of ethanol sensitivity and intoxication using performances in the screen, dowel, and grip strength tests, in 21 inbred strains of mice (2003)

Crabbe JC, Cotnam CJ, Cameron AJ, Schlumbohm JP, Rhodes JS, Metten P, Wahlsten D. Strain differences in three measures of ethanol intoxication in mice: the screen, dowel and grip strength tests. Genes Brain Behav. 2003 Aug;2(4):201-13.   PubMed 12953786  

Crabbe4 downloads
• Download Crabbe4 project data set     animal data, as uploaded
• Download Crabbe4 animal data matrix     with factor-related expansion applied as necessary
• Download Crabbe4 strain means, SD, N, etc.     one row per strain/sex/measure
Investigators John C Crabbe       Oregon Health & Science University,  Portland, OR
Pamela Metten       Oregon Health & Science University,  Portland, OR
Douglas Wahlsten       University of Windsor,  Windsor, Ontario CANADA
Participants Cotnam CJ, Cameron AJ, Schlumbohm JP, Rhodes JS
ContactJohn C Crabbe
AcknowledgementsFunding provided by NIH AA10760, AA12714, AA07468; Department of Veterans Affairs; Natural Sciences and Engineering Research Council of Canada.

Acknowledgements: Best K, Kliethermes CL, Rustay NR, Yu C-H, Zuraw JM, Bobo M.
Project type Phenotype strain survey data set
MPD identifiersCrabbe4     MPD:191
Data changelog No updates/corrections.       Initial release date: 02/2010.
Formatted citation
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An investigation of the pharmacokinetic differences of ethanol intoxication. Blood ethanol concentration (BEC) levels were determined before and after ethanol administration. This project has a complex study design involving multiple cohorts, as described in the protocol workflow table.

Procedures conducted:
• dowel balance test  Latency to fall 0 min and 30 min post-injection, 2 widths. Ethanol 2 g/kg.
• vertical wire mesh  Latency to fall 30 min post-injection. Ethanol 2 g/kg i.p.
• grip strength  Baseline vs. 30 min after ethanol 2 g/kg i.p.
• alcohol quantification  Blood alcohol concentration after ethanol 2 g/kg i.p., several timepoints.

Mice: inbred   21 strains   ♀♂   age 9-17wks   8 experimental groups