Crabbe1: Drug study: Evaluation of ethanol sensitivity and intoxication using motor incoordination in the balance beam and grid test, in 8 inbred strains of mice (2003)

Crabbe JC, Metten P, Yu CH, Schlumbohm JP, Cameron AJ, Wahlsten D. Genotypic Differences in Ethanol Sensitivity in Two Tests of Motor Incoordination. J Appl Physiol. 2003 Oct;95(4):1338-51. Epub 2003 Apr 18.   PubMed 12704090  

The investigator selected the most useful measurements for MPD accessioning. Supplemental data set includes scores for hanging or falling from the balance beam, raw misstep data, and grid data from 5-min intervals.

Crabbe1 downloads
• Download Crabbe1 project data set     animal data, as uploaded
• Download Crabbe1 animal data matrix     with factor-related expansion applied as necessary
• Download Crabbe1 strain means, SD, N, etc.     one row per strain/sex/measure
• Crabbe1 supplementary data
Investigators John C Crabbe       Oregon Health & Science University,  Portland, OR
Douglas Wahlsten       University of Windsor,  Windsor, Ontario CANADA
Participants Metten P, Yu C-H, Schlumbohm JP, Cameron AJ
ContactJohn C Crabbe
AcknowledgementsFunding provided by NIH AA10760, AA12714; Department of Veterans Affairs; Natural Sciences and Engineering Research Council of Canada (NSERC 45825).

Acknowledgements: Technical assistance provided by Best KL, Cotnam CJ, Dorow JA, Sibert JR, Zuraw JM; informatics assistance provided by Bobo M.
Project type Phenotype strain survey data set
MPD identifiersCrabbe1     MPD:154
Data changelog 1 update/correction.       Initial release date: 11/2003.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
An investigation of the genetic determinants of ethanol sensitivity and intoxication. Animals were assayed for motor and/or behavioral incoordination following saline administration in control vs. ethanol treated mice using balance beam and grid test apparatus. Four i.p. treatment group cohorts: (1) saline; (2) ethanol 1.0 mg/kg body weight; (3) ethanol 1.2 mg/kg; (4) ethanol 1.4 mg/kg.

Procedures conducted:
• balance beam  Ethanol i.p. (several doses) vs. control (saline). Missteps count. 3 beam lengths.
• grid test  Ethanol injection (several doses) vs. control (saline). Grid habituation, missteps rate.
• body weight 

Mice: inbred   8 strains   ♀♂   age 8wks   4 experimental groups