Phenotype measure:   Metten2   withdrawal_EtOH


  STRAIN COMPARISON PLOT
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Metten2 - withdrawal severity during 0-25h, area under curve of handling-induced convulsions scores



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested15 strains
Mean of the strain means45.7   AUC
Median of the strain means45.7   AUC
SD of the strain means± 19.7
Coefficient of variation (CV)0.432
Min–max range of strain means20.7   –   76.6   AUC
Mean sample size per strain19.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 14 102520.7159 7322.9083 9.2307 < 0.0001
Residuals 283 224509.5903 793.3201


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 76.6 26.0   23 5.43 0.34 21.0, 99.0 1.57
AKR/J m 29.7 33.2   16 8.3 1.12 -0.81
BALB/cByJ m 76.1 18.0   14 4.8 0.236 43.5, 97.0 1.54
BTBR T+ Itpr3tf/J m 36.6 28.5   10 9.01 0.778 3.0, 74.0 -0.46
C3H/HeJ m 31.0 34.1   18 8.04 1.1 -0.74
C57BL/6J m 21.3 20.9   28 3.96 0.982 -1.24
C57BR/cdJ m 45.7 30.5   27 5.86 0.666 1.0, 92.0 0.0
C57L/J m 38.6 27.5   26 5.4 0.713 -0.36
CBA/J m 49.8 21.5   28 4.07 0.432 3.0, 81.0 0.21
CE/J m 21.9 29.6   10 9.36 1.35 -1.21
DBA/1J m 48.1 34.3   10 10.8 0.712 6.5, 97.0 0.12
DBA/2J m 55.5 39.6   22 8.45 0.714 0.5
FVB/NJ m 57.8 29.6   29 5.49 0.512 2.0, 95.0 0.61
PL/J m 20.7 22.5   18 5.31 1.09 -1.27
SJL/J m 75.8 23.3   19 5.35 0.307 44.5, 106.0 1.53


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 76.6304 5.873 88.1908 65.0701
AKR/J m 29.6562 7.0415 43.5166 15.7959
BALB/cByJ m 76.1429 7.5277 90.9602 61.3255
BTBR T+ Itpr3tf/J m 36.65 8.9069 54.1821 19.1179
C3H/HeJ m 31.0 6.6388 44.0676 17.9324
C57BL/6J m 21.3393 5.3229 31.8167 10.8619
C57BR/cdJ m 45.7222 5.4205 56.3919 35.0525
C57L/J m 38.5962 5.5238 49.4691 27.7232
CBA/J m 49.8214 5.3229 60.2989 39.344
CE/J m 21.95 8.9069 39.4821 4.4179
DBA/1J m 48.1 8.9069 65.6321 30.5679
DBA/2J m 55.5 6.005 67.3201 43.6799
FVB/NJ m 57.7586 5.2303 68.0538 47.4634
PL/J m 20.7222 6.6388 33.7899 7.6546
SJL/J m 75.8421 6.4617 88.5612 63.123




  GWAS USING LINEAR MIXED MODELS