Project measure / variable:   Metten2   withdrawal_EtOHadj

ID, description, units MPD:19508   withdrawal_EtOHadj   withdrawal severity during 0-25h, area under curve of handling-induced convulsions scores normalized to controls   [AUC]  
ethanol study
Data set, strains Metten2   inbred   15 strains     sex: m     age: 8-15wks
Procedure behavior observation
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  STRAIN COMPARISON PLOT
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Metten2 - withdrawal severity during 0-25h, area under curve of handling-induced convulsions scores normalized to controls



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested15 strains
Mean of the strain means47.8   AUC
Median of the strain means49.5   AUC
SD of the strain means± 13.5
Coefficient of variation (CV)0.282
Min–max range of strain means25.4   –   75.8   AUC
Mean sample size per strain11.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 14 31414.087 2243.8634 9.3244 < 0.0001
Residuals 155 37300.0508 240.6455


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 47.2 3.98   14 1.06 0.0842 34.6, 51.1 -0.05
AKR/J m 53.1 27.2   8 9.6 0.511 16.9, 88.9 0.39
BALB/cByJ m 31.2 5.4   6 2.21 0.173 20.2, 34.2 -1.23
BTBR T+ Itpr3tf/J m 49.5 10.2   5 4.54 0.205 37.6, 62.1 0.12
C3H/HeJ m 59.6 21.6   9 7.19 0.362 31.8, 85.8 0.87
C57BL/6J m 25.4 20.6   19 4.74 0.811 -1.06, 76.4 -1.66
C57BR/cdJ m 57.8 14.5   18 3.42 0.251 26.3, 84.8 0.74
C57L/J m 48.8 16.7   17 4.04 0.342 8.78, 71.3 0.07
CBA/J m 34.6 11.2   18 2.63 0.323 18.4, 53.4 -0.98
CE/J m 52.4 20.8   4 10.4 0.396 38.0, 82.0 0.34
DBA/1J m 57.1 14.5   4 7.27 0.255 38.8, 71.8 0.69
DBA/2J m 75.8 8.58   12 2.48 0.113 60.4, 83.8 2.07
FVB/NJ m 53.1 10.1   16 2.52 0.19 38.5, 66.5 0.39
PL/J m 28.0 24.7   9 8.23 0.881 3.78, 84.3 -1.47


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 47.2071 4.146 55.397 39.0173
AKR/J m 53.15 5.4846 63.9842 42.3158
BALB/cByJ m 31.2 6.3331 43.7102 18.6898
BTBR T+ Itpr3tf/J m 49.5 6.9375 63.2043 35.7957
C3H/HeJ m 59.6333 5.1709 69.8479 49.4188
C57BL/6J m 25.4368 3.5589 32.467 18.4067
C57BR/cdJ m 57.7722 3.6564 64.995 50.5494
C57L/J m 48.7694 3.7624 56.2016 41.3372
CBA/J m 34.5667 3.6564 41.7895 27.3439
CE/J m 52.375 7.7564 67.6968 37.0532
DBA/1J m 57.15 7.7564 72.4718 41.8282
DBA/2J m 75.775 4.4781 84.6211 66.9289
FVB/NJ m 53.0625 3.8782 60.7234 45.4016
PL/J m 28.0178 5.1709 38.2323 17.8032
SJL/J m 44.0545 4.6773 53.294 34.8151




  GWAS USING LINEAR MIXED MODELS