Project measure / variable:   Finn1   10pct_EtOHsach

ID, description, units MPD:25607   10pct_EtOHsach   dose of ethanol voluntarily consumed at 10% ethanol in water with 0.2% saccharin   [g/kg]  
ethanol study
Data set, strains Finn1   inbred   22 strains     sex: both     age: 11-12wks
Procedure bottle choice test
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  STRAIN COMPARISON PLOT
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Finn1 - dose of ethanol voluntarily consumed at 10% ethanol in water with 0.2% saccharin



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested22 strains22 strains
Mean of the strain means11.6   g/kg 7.60   g/kg
Median of the strain means12.0   g/kg 6.04   g/kg
SD of the strain means± 6.99 ± 5.71
Coefficient of variation (CV)0.604 0.752
Min–max range of strain means0.920   –   24.5   g/kg 1.08   –   18.9   g/kg
Mean sample size per strain7.2   mice 7.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1295.8355 1295.8355 61.4377 < 0.0001
strain 21 11354.0726 540.6701 25.6341 < 0.0001
sex:strain 21 941.3368 44.8256 2.1253 0.0033
Residuals 285 6011.1818 21.0919


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 3.96 2.23   8 0.79 0.564 0.63, 8.14 -1.09
129S1/SvImJ m 2.05 1.76   8 0.621 0.857 0.57, 6.18 -0.97
A/J f 3.9 6.75   8 2.39 1.73 -1.1
A/J m 2.74 6.51   8 2.3 2.37 -0.85
BALB/cByJ f 18.0 1.97   8 0.698 0.11 13.9, 20.4 0.92
BALB/cByJ m 14.7 2.91   8 1.03 0.198 7.81, 17.4 1.24
BTBR T+ Itpr3tf/J f 2.91 2.22   7 0.838 0.762 0.82, 7.18 -1.24
BTBR T+ Itpr3tf/J m 1.69 2.13   8 0.754 1.26 0.74, 6.96 -1.03
BUB/BnJ f 0.92 1.59   3 0.92 1.73 -1.52
BUB/BnJ m 2.44 2.07   7 0.784 0.849 0.48, 5.57 -0.9
C57BL/6J f 24.5 1.34   8 0.472 0.0545 22.6, 26.0 1.85
C57BL/6J m 18.9 2.23   8 0.787 0.118 16.1, 22.8 1.98
C57BLKS/J f 16.9 2.93   8 1.04 0.174 11.7, 20.1 0.76
C57BLKS/J m 12.6 4.84   7 1.83 0.383 2.85, 16.2 0.88
C58/J f 18.9 5.79   6 2.36 0.306 7.47, 23.0 1.05
C58/J m 17.4 5.6   7 2.12 0.322 7.84, 24.3 1.72
CZECHII/EiJ f 15.9 8.06   3 4.65 0.507 7.52, 23.6 0.62
CZECHII/EiJ m 1.08 0.9   5 0.403 0.83 0.45, 2.65 -1.14
DBA/2J f 1.62 1.14   7 0.43 0.702 -1.42
DBA/2J m 1.34 1.28   8 0.452 0.953 0.58, 4.46 -1.1
FVB/NJ f 19.8 9.62   7 3.64 0.486 4.32, 28.9 1.18
FVB/NJ m 15.9 4.7   8 1.66 0.295 9.02, 23.2 1.45
I/LnJ f 12.6 8.18   8 2.89 0.652 0.15
I/LnJ m 5.72 4.44   8 1.57 0.776 -0.33
LP/J f 2.27 2.41   8 0.853 1.07 0.34, 6.88 -1.33
LP/J m 3.58 4.21   8 1.49 1.18 0.77, 13.5 -0.7
MA/MyJ f 9.71 8.31   8 2.94 0.856 0.68, 23.1 -0.27
MA/MyJ m 5.62 4.47   8 1.58 0.797 0.58, 14.0 -0.35
NOD/ShiLtJ f 12.4 8.86   8 3.13 0.712 1.36, 22.1 0.12
NOD/ShiLtJ m 8.26 5.36   8 1.9 0.649 1.08, 15.2 0.12
NON/ShiLtJ f 11.6 5.74   8 2.03 0.495 0.86, 16.5 0.0
NON/ShiLtJ m 3.55 3.87   8 1.37 1.09 0.23, 12.2 -0.71
NZB/BlNJ f 13.6 2.41   8 0.854 0.178 8.87, 17.2 0.29
NZB/BlNJ m 9.14 2.52   8 0.891 0.276 6.27, 12.7 0.27
NZW/LacJ f 9.3 7.42   6 3.03 0.798 2.51, 21.6 -0.33
NZW/LacJ m 3.23 1.71   10 0.541 0.53 1.1, 6.29 -0.76
PERA/EiJ f 19.8 0.722   5 0.323 0.0365 18.8, 20.6 1.18
PERA/EiJ m 15.1 2.1   9 0.701 0.139 10.7, 18.5 1.31
RIIIS/J f 9.41 2.28   8 0.805 0.242 5.53, 13.3 -0.31
RIIIS/J m 6.35 2.48   8 0.876 0.391 2.82, 9.96 -0.22
SEA/GnJ f 7.64 6.28   8 2.22 0.823 0.6, 17.9 -0.56
SEA/GnJ m 7.72 4.05   8 1.43 0.525 2.87, 15.7 0.02
SM/J f 19.1 2.72   8 0.962 0.143 14.6, 24.0 1.08
SM/J m 8.05 6.17   8 2.18 0.766 1.58, 19.3 0.08


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 3.96 1.6237 7.156 0.764
129S1/SvImJ m 2.0513 1.6237 5.2473 0.0
A/J f 3.8975 1.6237 7.0935 0.7015
A/J m 2.7437 1.6237 5.9398 0.0
BALB/cByJ f 17.9625 1.6237 21.1585 14.7665
BALB/cByJ m 14.7387 1.6237 17.9348 11.5427
BTBR T+ Itpr3tf/J f 2.91 1.7358 6.3267 0.0
BTBR T+ Itpr3tf/J m 1.6938 1.6237 4.8898 0.0
BUB/BnJ f 0.92 2.6515 6.1391 0.0
BUB/BnJ m 2.4443 1.7358 5.861 0.0
C57BL/6J f 24.525 1.6237 27.721 21.329
C57BL/6J m 18.8625 1.6237 22.0585 15.6665
C57BLKS/J f 16.8875 1.6237 20.0835 13.6915
C57BLKS/J m 12.62 1.7358 16.0367 9.2033
C58/J f 18.945 1.8749 22.6354 15.2546
C58/J m 17.3771 1.7358 20.7938 13.9605
CZECHII/EiJ f 15.9067 2.6515 21.1257 10.6876
CZECHII/EiJ m 1.084 2.0539 5.1267 0.0
DBA/2J f 1.6214 1.7358 5.0381 0.0
DBA/2J m 1.3412 1.6237 4.5373 0.0
FVB/NJ f 19.8129 1.7358 23.2295 16.3962
FVB/NJ m 15.8987 1.6237 19.0948 12.7027
I/LnJ f 12.555 1.6237 15.751 9.359
I/LnJ m 5.7225 1.6237 8.9185 2.5265
LP/J f 2.265 1.6237 5.461 0.0
LP/J m 3.58 1.6237 6.776 0.384
MA/MyJ f 9.705 1.6237 12.901 6.509
MA/MyJ m 5.615 1.6237 8.811 2.419
NOD/ShiLtJ f 12.4463 1.6237 15.6423 9.2502
NOD/ShiLtJ m 8.2588 1.6237 11.4548 5.0627
NON/ShiLtJ f 11.5812 1.6237 14.7773 8.3852
NON/ShiLtJ m 3.5512 1.6237 6.7473 0.3552
NZB/BlNJ f 13.5713 1.6237 16.7673 10.3752
NZB/BlNJ m 9.1438 1.6237 12.3398 5.9477
NZW/LacJ f 9.2983 1.8749 12.9888 5.6079
NZW/LacJ m 3.226 1.4523 6.0846 0.3674
PERA/EiJ f 19.82 2.0539 23.8627 15.7773
PERA/EiJ m 15.1111 1.5309 18.1243 12.0979
RIIIS/J f 9.4125 1.6237 12.6085 6.2165
RIIIS/J m 6.3463 1.6237 9.5423 3.1502
SEA/GnJ f 7.6413 1.6237 10.8373 4.4452
SEA/GnJ m 7.7213 1.6237 10.9173 4.5252
SM/J f 19.075 1.6237 22.271 15.879
SM/J m 8.0525 1.6237 11.2485 4.8565


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 3.0056 1.1481 5.2655 0.7457
A/J both 3.3206 1.1481 5.5805 1.0607
BALB/cByJ both 16.3506 1.1481 18.6105 14.0907
BTBR T+ Itpr3tf/J both 2.3019 1.1884 4.6411 0.0
BUB/BnJ both 1.6821 1.5846 4.8011 0.0
C57BL/6J both 21.6937 1.1481 23.9537 19.4338
C57BLKS/J both 14.7538 1.1884 17.093 12.4145
C58/J both 18.1611 1.2775 20.6757 15.6465
CZECHII/EiJ both 8.4953 1.677 11.7962 5.1945
DBA/2J both 1.4813 1.1884 3.8206 0.0
FVB/NJ both 17.8558 1.1884 20.195 15.5166
I/LnJ both 9.1388 1.1481 11.3987 6.8788
LP/J both 2.9225 1.1481 5.1824 0.6626
MA/MyJ both 7.66 1.1481 9.9199 5.4001
NOD/ShiLtJ both 10.3525 1.1481 12.6124 8.0926
NON/ShiLtJ both 7.5662 1.1481 9.8262 5.3063
NZB/BlNJ both 11.3575 1.1481 13.6174 9.0976
NZW/LacJ both 6.2622 1.1858 8.5962 3.9281
PERA/EiJ both 17.4656 1.2808 19.9866 14.9445
RIIIS/J both 7.8794 1.1481 10.1393 5.6195
SEA/GnJ both 7.6813 1.1481 9.9412 5.4213
SM/J both 13.5638 1.1481 15.8237 11.3038




  GWAS USING LINEAR MIXED MODELS