Crabbe3: Drug study: Evaluation of ethanol intoxication using the rotarod in 22 inbred strains of mice (2003)

Rustay NR, Wahlsten D, Crabbe JC. Assessment of genetic susceptibility to ethanol intoxication in mice. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2917-22. Epub 2003 Feb 12.   PubMed 12584362  


       
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Participants John C Crabbe       Oregon Health & Science University Portland, OR
Douglas Wahlsten       University of Windsor Windsor, Ontario CANADA
With: Rustay NR
ContactJohn C Crabbe     crabbe@ohsu.edu
AcknowledgementsGenerous funds from AstraZeneca were used to defray the cost of mice through the Mouse Phenome Project Collaborations Program.
Project type Phenotype strain survey data set
MPD identifiersCrabbe3     MPD:158
Data changelog No updates/corrections.       Initial release date: 02/2010.
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Animals were evaluated on an accelerating and fixed speed rotarod following ethanol administration. This project has a complex study design involving multiple cohorts, as described in the protocol workflow table.

Summary of procedures that were conducted
• body weight
• rotarod Baseline and ethanol i.p. 3 fixed speeds (several doses) and accelerating.
Mice: inbred   22 strains   ♀♂   age 9-17wks   9 cohorts

Select table page: First Prev Next Last
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Crabbe3 15810 rotarod ethanol fixed speed 3 rpm rotarod (latency to fall)   [s]     ethanol i.p. g/kg:    1    2    3 inbred 9 both 9-17wks N=4
    Crabbe3 15815 rotarod ethanol fixed speed 6 rpm rotarod (latency to fall)   [s]     ethanol i.p. g/kg:    1    2    3 inbred 9 both 9-17wks N=4
    Crabbe3 15820 rotarod ethanol fixed speed 10 rpm rotarod (latency to fall)   [s]     ethanol i.p. g/kg:    1    2    3 inbred 7 both 9-17wks N=3
    Crabbe3 15830 rotarod (none) accelerating rotarod (ARR1) acquisition trial average over all trials (20 rpm/min)   [s]  ARR1_performance inbred 8 both 9-17wks N=6
    Crabbe3 15831 rotarod (none) accelerating rotarod (ARR1) acquisition trial average of last 3 trials minus average of first 3 trials (20 rpm/min)   [s]  ARR1_improvement inbred 8 both 9-17wks N=6
    Crabbe3 15840 rotarod ethanol accelerating rotarod (latency to fall), test day 1 20 rpm/min (ARR1)   [s]     baseline    ethanol    Δchange (ethanol effect) inbred 8 both 9-17wks N=6
    Crabbe3 15845 rotarod ethanol accelerating rotarod (latency to fall), test day 2 30 rpm/min (ARR1)   [s]     baseline    ethanol    Δchange (ethanol effect) inbred 8 both 9-17wks N=5
    Crabbe3 15850 rotarod (none) accelerating rotarod (ARR2) acquisition trial average over all trials (20 rpm/min)   [s]  ARR2_performance inbred 21 both 9-17wks N=10
    Crabbe3 15851 rotarod (none) accelerating rotarod (ARR2) acquisition trial average of first 2 trials minus average of last 2 trials (20 rpm/min)   [s]  ARR2_improvement inbred 21 both 9-17wks N=10
    Crabbe3 15855 rotarod ethanol accelerating rotarod (latency to fall), test 20 rpm/min (ARR2)   [s]     baseline    ethanol inbred 21 both 9-17wks N=9
    Crabbe3 15857 rotarod ethanol accelerating rotarod (ARR2) average latency of post-injection trials minus pre-injection trials (ETPOST - ETBASE) (20 rpm/min)   [s]  ARR2_chg_20rpm inbred 21 both 9-17wks N=9
    Crabbe3 15858 rotarod (none) accelerating rotarod (ARR2) average latency of post-injection saline control minus pre-injection saline control (SALPOST - SALBASE) (20 rpm/min)   [s]  ARR2_chg_20rpm_saline inbred 21 both 9-17wks N=9
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