MPD: Data set: Crabbe3

Rustay NR, Wahlsten D, Crabbe JC. Assessment of genetic susceptibility to ethanol intoxication in mice. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2917-22. Epub 2003 Feb 12. PubMed 12584362

Animals were evaluated on an accelerating and fixed speed rotarod following ethanol administration. This project has a complex study design involving multiple cohorts, as described in the protocol workflow table.

Procedures conducted:

• body weight
• rotarod		Baseline and ethanol i.p. 3 fixed speeds (several doses) and accelerating.

Crabbe3 downloads
• Download Crabbe3 project data set animal data, as uploaded
• Download Crabbe3 animal data matrix with factor-related expansion applied as necessary
• Download Crabbe3 strain means, SD, N, etc. one row per strain/sex/measure
• Crabbe3 supplementary data

Ontology terms mapped to Crabbe3 measures:

Investigators	John C Crabbe Oregon Health & Science University, Portland, OR Douglas Wahlsten University of Windsor, Windsor, Ontario CANADA
Participants	Rustay NR
Contact	John C Crabbe crabbe@ohsu.edu
Acknowledgements	Generous funds from AstraZeneca were used to defray the cost of mice through the Mouse Phenome Project Collaborations Program.
Project type	Phenotype strain survey data set
MPD identifiers	Crabbe3 MPD:158
Data changelog	No updates/corrections. Initial release date: 02/2010.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Crabbe3:1	Crabbe3	body weight	(none)	body weight on test day (local parameter) [g] bw 15801	inbred	9	both	9-17wks	N=17

Crabbe3:10	Crabbe3	rotarod	ethanol	latency to fall, fixed speed 3 rpm rotarod [s] FS_3rpm_EtOH 15810 dose (g/kg): 1 2 3	inbred	9	both	9-17wks	N=4

Crabbe3:15	Crabbe3	rotarod	ethanol	latency to fall, fixed speed 6 rpm rotarod [s] FS_6rpm_EtOH 15815 dose (g/kg) 1 2 3	inbred	9	both	9-17wks	N=3

Crabbe3:20	Crabbe3	rotarod	ethanol	latency to fall, fixed speed 10 rpm rotarod [s] FS_10rpm_EtOH 15820 dose (g/kg): 1 2 3	inbred	9	both	9-17wks	N=3

Crabbe3:30	Crabbe3	rotarod	(none)	accelerating rotarod (ARR1) acquisition trial average over all trials (20 rpm/min) [s] ARR1_performance 15830	inbred	8	both	9-17wks	N=6

Crabbe3:31	Crabbe3	rotarod	(none)	accelerating rotarod (ARR1) acquisition trial average of last 3 trials minus average of first 3 trials (20 rpm/min) [s] ARR1_improvement 15831	inbred	8	both	9-17wks	N=6

Crabbe3:40	Crabbe3	rotarod	ethanol	latency to-fall, accelerating rotarod, test day 1 20 rpm/min (ARR1) [s] ARR1_20rpm 15840 baseline ethanol difference	inbred	8	both	9-17wks	N=6

Crabbe3:45	Crabbe3	rotarod	ethanol	latency to-fall, accelerating rotarod, test day 2 30 rpm/min (ARR1) [s] ARR1_30rpm 15845 baseline ethanol difference	inbred	8	both	9-17wks	N=6

Crabbe3:50	Crabbe3	rotarod	(none)	accelerating rotarod (ARR2) acquisition trial average over all trials (20 rpm/min) [s] ARR2_performance 15850	inbred	21	both	9-17wks	N=9

Crabbe3:51	Crabbe3	rotarod	(none)	accelerating rotarod (ARR2) acquisition trial average of first 2 trials minus average of last 2 trials (20 rpm/min) [s] ARR2_improvement 15851	inbred	21	both	9-17wks	N=9

Crabbe3:55	Crabbe3	rotarod	ethanol	latency to fall, accelerating rotarod, 20 rpm/min (ARR2) [s] ARR2_20rpm 15855 baseline ethanol	inbred	21	both	9-17wks	N=9

Crabbe3:57	Crabbe3	rotarod	ethanol	average latency to fall, accelerating rotarod, 20 rpm/min (ARR2), post-injection trials minus pre-injection trials (ETPOST - ETBASE) [s] ARR2_chg_20rpm 15857	inbred	21	both	9-17wks	N=9

Crabbe3:58	Crabbe3	rotarod	(none)	average latency to fall, accelerating rotarod, 20 rpm/min (ARR2), post-injection saline control minus pre-injection saline control (SALPOST - SALBASE) [s] ARR2_chg_20rpm_saline 15858	inbred	21	both	9-17wks	N=9

Crabbe3: Drug study: Evaluation of ethanol intoxication using the rotarod in 22 inbred strains of mice (2003)