Phenotype measure:   Crabbe3   ARR2_chg_20rpm

ID, description, units MPD:15857   ARR2_chg_20rpm   average latency to fall, accelerating rotarod, 20 rpm/min (ARR2), post-injection trials minus pre-injection trials (ETPOST - ETBASE)   [s]
ethanol study
Data set, strains Crabbe3   inbred   21 strains     sex: both     age: 9-17wks
Procedure rotarod
Ontology mappings

  STRAIN COMPARISON PLOT
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Crabbe3 - average latency to fall, accelerating rotarod, 20 rpm/min (ARR2), post-injection trials minus pre-injection trials (ETPOST - ETBASE)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested21 strains21 strains
Mean of the strain means-12.3   s -14.8   s
Median of the strain means-13.6   s -16.2   s
SD of the strain means± 19.3 ± 15.6
Coefficient of variation (CV)-1.57 -1.05
Min–max range of strain means-51.5   –   19.3   s -43.0   –   7.81   s
Mean sample size per strain9.4   mice 9.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1.9095 1.9095 0.0025 0.9602
strain 20 94290.382 4714.5191 6.1587 < 0.0001
sex:strain 20 24738.65 1236.9325 1.6158 0.0468
Residuals 344 263335.6886 765.5107


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f -13.7 8.1   10 2.56 -0.594 -27.5, -1.0 -0.07
129S1/SvImJ m -19.4 8.03   10 2.54 -0.414 -33.0, -7.5 -0.3
A/J f -11.7 13.7   8 4.85 -1.17 -33.5, 13.0 0.03
A/J m -7.6 14.3   10 4.51 -1.88 -31.5, 24.5 0.46
AKR/J f -3.39 12.7   9 4.24 -3.75 -24.0, 19.0 0.46
AKR/J m 7.81 12.1   8 4.27 1.55 -9.0, 26.0 1.45
BALB/cByJ f 11.2 16.5   10 5.21 1.48 -8.0, 45.5 1.22
BALB/cByJ m 1.0 13.6   10 4.29 13.6 -21.5, 22.5 1.01
BTBR T+ Itpr3tf/J f -40.5 27.9   12 8.05 -0.688 -82.5, 2.0 -1.46
BTBR T+ Itpr3tf/J m -43.0 29.4   6 12.0 -0.684 -81.0, -10.0 -1.81
C3H/HeJ f -4.75 16.8   10 5.31 -3.54 -36.5, 29.0 0.39
C3H/HeJ m -23.3 16.1   8 5.69 -0.69 -42.0, -7.0 -0.55
C57BL/6J f -13.6 16.6   8 5.86 -1.22 -40.0, 7.0 -0.07
C57BL/6J m 2.35 12.4   10 3.92 5.28 -19.0, 23.0 1.1
C57L/J f -17.6 15.1   10 4.77 -0.857 -45.5, 5.5 -0.28
C57L/J m -10.5 26.9   8 9.5 -2.56 -61.0, 34.0 0.27
C58/J f -14.8 57.7   10 18.2 -3.89 -95.5, 63.5 -0.13
C58/J m -13.7 26.1   10 8.25 -1.91 -53.0, 36.0 0.07
CAST/EiJ f 1.7 21.0   5 9.41 12.4 -21.0, 33.5 0.72
CAST/EiJ m -37.8 48.5   8 17.2 -1.28 -126.0, 34.0 -1.48
DBA/2J f 3.9 14.9   10 4.71 3.82 -23.0, 22.0 0.84
DBA/2J m 1.12 9.33   8 3.3 8.29 -13.0, 17.0 1.02
FVB/NJ f 17.3 18.6   10 5.87 1.07 -7.5, 53.5 1.53
FVB/NJ m 5.32 8.92   11 2.69 1.68 -10.0, 19.5 1.29
MOLF/EiJ f 19.3 42.9   8 15.2 2.22 -45.5, 78.5 1.64
MOLF/EiJ m -26.8 41.1   6 16.8 -1.53 -97.5, 16.0 -0.77
NOD/ShiLtJ f -23.8 32.8   12 9.48 -1.38 -77.5, 30.5 -0.6
NOD/ShiLtJ m -35.2 43.2   12 12.5 -1.23 -128.0, 12.0 -1.31
NZB/BlNJ f -1.58 14.2   6 5.81 -9.0 -24.0, 17.5 0.55
NZB/BlNJ m 4.83 20.0   12 5.77 4.13 -23.5, 39.5 1.26
PERA/EiJ f -51.5 51.5   10 16.3 -0.998 -136.0, 26.0 -2.03
PERA/EiJ m -29.2 56.7   12 16.4 -1.94 -148.0, 24.0 -0.93
PL/J f -50.4 37.7   12 10.9 -0.747 -110.0, 8.0 -1.97
PL/J m -23.6 21.6   8 7.63 -0.914 -53.5, 8.0 -0.57
SJL/J f -2.0 13.2   8 4.68 -6.62 -32.0, 9.5 0.53
SJL/J m 0.833 8.47   12 2.45 10.2 -12.0, 15.5 1.0
SM/J f -22.5 27.8   14 7.43 -1.23 -68.5, 22.0 -0.53
SM/J m -20.3 19.6   10 6.2 -0.966 -43.0, 11.5 -0.36
SPRET/EiJ f -24.3 15.5   3 8.95 -0.637 -40.0, -9.0 -0.62
SPRET/EiJ m -16.2 16.6   2   11.7 -1.02 -28.0, -4.5 -0.09
SWR/J f -15.1 19.9   10 6.3 -1.32 -69.0, 3.5 -0.15
SWR/J m -26.6 27.8   10 8.8 -1.05 -63.5, 14.5 -0.76


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f -13.65 8.7493 3.559 -30.859
129S1/SvImJ m -19.4 8.7493 -2.191 -36.609
A/J f -11.6875 9.7821 7.5527 -30.9277
A/J m -7.6 8.7493 9.609 -24.809
AKR/J f -3.3889 9.2226 14.7509 -21.5287
AKR/J m 7.8125 9.7821 27.0527 -11.4277
BALB/cByJ f 11.15 8.7493 28.359 -6.059
BALB/cByJ m 1.0 8.7493 18.209 -16.209
BTBR T+ Itpr3tf/J f -40.5417 7.987 -24.8321 -56.2512
BTBR T+ Itpr3tf/J m -43.0 11.2954 -20.7833 -65.2167
C3H/HeJ f -4.75 8.7493 12.459 -21.959
C3H/HeJ m -23.3125 9.7821 -4.0723 -42.5527
C57BL/6J f -13.625 9.7821 5.6152 -32.8652
C57BL/6J m 2.35 8.7493 19.559 -14.859
C57L/J f -17.6 8.7493 -0.391 -34.809
C57L/J m -10.5 9.7821 8.7402 -29.7402
C58/J f -14.85 8.7493 2.359 -32.059
C58/J m -13.65 8.7493 3.559 -30.859
CAST/EiJ f 1.7 12.3734 26.0371 -22.6371
CAST/EiJ m -37.8125 9.7821 -18.5723 -57.0527
DBA/2J f 3.9 8.7493 21.109 -13.309
DBA/2J m 1.125 9.7821 20.3652 -18.1152
FVB/NJ f 17.3 8.7493 34.509 0.091
FVB/NJ m 5.3182 8.3422 21.7263 -11.0899
MOLF/EiJ f 19.3125 9.7821 38.5527 0.0723
MOLF/EiJ m -26.8333 11.2954 -4.6167 -49.05
NOD/ShiLtJ f -23.7917 7.987 -8.0821 -39.5012
NOD/ShiLtJ m -35.2083 7.987 -19.4988 -50.9179
NZB/BlNJ f -1.5833 11.2954 20.6333 -23.8
NZB/BlNJ m 4.8333 7.987 20.5429 -10.8762
PERA/EiJ f -51.55 8.7493 -34.341 -68.759
PERA/EiJ m -29.1667 7.987 -13.4571 -44.8762
PL/J f -50.4167 7.987 -34.7071 -66.1262
PL/J m -23.625 9.7821 -4.3848 -42.8652
SJL/J f -2.0 9.7821 17.2402 -21.2402
SJL/J m 0.8333 7.987 16.5429 -14.8762
SM/J f -22.5357 7.3945 -7.9915 -37.0799
SM/J m -20.3 8.7493 -3.091 -37.509
SPRET/EiJ f -24.3333 15.974 7.0858 -55.7524
SPRET/EiJ m -16.25 19.5641 22.2304 -54.7304
SWR/J f -15.05 8.7493 2.159 -32.259
SWR/J m -26.55 8.7493 -9.341 -43.759


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both -16.525 6.1867 -4.3564 -28.6936
A/J both -9.6438 6.562 3.263 -22.5505
AKR/J both 2.2118 6.7221 15.4334 -11.0098
BALB/cByJ both 6.075 6.1867 18.2436 -6.0936
BTBR T+ Itpr3tf/J both -41.7708 6.917 -28.166 -55.3757
C3H/HeJ both -14.0313 6.562 -1.1245 -26.938
C57BL/6J both -5.6375 6.562 7.2692 -18.5442
C57L/J both -14.05 6.562 -1.1433 -26.9567
C58/J both -14.25 6.1867 -2.0814 -26.4186
CAST/EiJ both -18.0563 7.8866 -2.5443 -33.5682
DBA/2J both 2.5125 6.562 15.4192 -10.3942
FVB/NJ both 11.3091 6.0445 23.1979 -0.5797
MOLF/EiJ both -3.7604 7.4712 10.9345 -18.4554
NOD/ShiLtJ both -29.5 5.6477 -18.3917 -40.6083
NZB/BlNJ both 1.625 6.917 15.2299 -11.9799
PERA/EiJ both -40.3583 5.9233 -28.7078 -52.0088
PL/J both -37.0208 6.3143 -24.6013 -49.4403
SJL/J both -0.5833 6.3143 11.8362 -13.0028
SM/J both -21.4179 5.7278 -10.152 -32.6838
SPRET/EiJ both -20.2917 12.6286 4.5473 -45.1306
SWR/J both -20.8 6.1867 -8.6314 -32.9686




  GWAS USING LINEAR MIXED MODELS