Phenotype measure:   Finn1   6pct_EtOHsach

ID, description, units MPD:25606   6pct_EtOHsach   dose of ethanol voluntarily consumed at 6% ethanol in water with 0.2% saccharin   [g/kg]
ethanol study
Data set, strains Finn1   inbred   22 strains     sex: both     age: 11-12wks
Procedure bottle choice test
Ontology mappings

  STRAIN COMPARISON PLOT
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Finn1 - dose of ethanol voluntarily consumed at 6% ethanol in water with 0.2% saccharin



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested22 strains22 strains
Mean of the strain means10.5   g/kg 6.89   g/kg
Median of the strain means11.8   g/kg 6.12   g/kg
SD of the strain means± 6.12 ± 4.58
Coefficient of variation (CV)0.583 0.664
Min–max range of strain means1.29   –   20.0   g/kg 0.586   –   14.8   g/kg
Mean sample size per strain7.3   mice 7.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1125.5522 1125.5522 102.4083 < 0.0001
strain 21 8417.8864 400.8517 36.4715 < 0.0001
sex:strain 21 702.5507 33.4548 3.0439 < 0.0001
Residuals 288 3165.3604 10.9908


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 4.65 2.35   8 0.832 0.506 2.47, 8.68 -0.96
129S1/SvImJ m 1.75 1.87   8 0.659 1.07 0.17, 5.38 -1.12
A/J f 1.67 2.1   8 0.743 1.26 -1.44
A/J m 3.3 2.74   8 0.967 0.829 0.19, 7.89 -0.79
BALB/cByJ f 13.2 2.88   8 1.02 0.219 6.45, 15.3 0.44
BALB/cByJ m 9.86 1.41   8 0.497 0.143 6.95, 11.3 0.65
BTBR T+ Itpr3tf/J f 2.43 1.85   8 0.653 0.758 0.87, 6.53 -1.32
BTBR T+ Itpr3tf/J m 0.889 0.494   8 0.175 0.556 0.14, 1.54 -1.31
BUB/BnJ f 3.12 2.46   3 1.42 0.79 0.48, 5.36 -1.21
BUB/BnJ m 2.28 2.7   7 1.02 1.19 -1.01
C57BL/6J f 20.0 1.83   8 0.647 0.0917 17.1, 21.8 1.55
C57BL/6J m 14.8 1.77   8 0.625 0.12 11.4, 16.9 1.73
C57BLKS/J f 15.8 1.86   8 0.658 0.118 12.7, 18.2 0.86
C57BLKS/J m 11.1 3.99   7 1.51 0.359 2.4, 14.2 0.92
C58/J f 18.3 2.89   8 1.02 0.158 14.5, 22.1 1.27
C58/J m 13.8 3.62   7 1.37 0.263 8.05, 18.6 1.51
CZECHII/EiJ f 13.6 10.4   3 6.02 0.767 1.58, 20.3 0.5
CZECHII/EiJ m 0.828 1.05   6 0.427 1.26 0.28, 2.9 -1.33
DBA/2J f 1.29 0.841   7 0.318 0.653 0.44, 2.5 -1.51
DBA/2J m 0.586 0.414   8 0.146 0.706 0.18, 1.43 -1.38
FVB/NJ f 16.6 5.94   7 2.24 0.357 5.95, 23.2 0.99
FVB/NJ m 11.8 2.52   8 0.89 0.214 6.05, 13.8 1.07
I/LnJ f 17.3 2.11   8 0.744 0.122 14.1, 20.6 1.11
I/LnJ m 10.8 2.48   8 0.878 0.23 8.4, 16.0 0.85
LP/J f 2.37 1.95   8 0.69 0.824 0.21, 5.17 -1.33
LP/J m 3.96 3.96   8 1.4 1.0 0.16, 10.4 -0.64
MA/MyJ f 11.5 5.17   8 1.83 0.449 0.78, 15.3 0.16
MA/MyJ m 5.97 4.19   8 1.48 0.702 0.71, 11.2 -0.2
NOD/ShiLtJ f 12.1 6.42   8 2.27 0.53 1.49, 19.8 0.26
NOD/ShiLtJ m 8.55 4.67   8 1.65 0.546 1.18, 13.8 0.36
NON/ShiLtJ f 8.87 5.1   7 1.93 0.575 0.54, 15.1 -0.27
NON/ShiLtJ m 2.31 1.15   8 0.408 0.498 0.42, 3.88 -1.0
NZB/BlNJ f 12.5 2.23   8 0.787 0.178 8.58, 15.2 0.33
NZB/BlNJ m 11.0 2.22   8 0.785 0.201 6.74, 13.9 0.9
NZW/LacJ f 7.28 3.56   6 1.45 0.488 1.3, 11.0 -0.53
NZW/LacJ m 4.3 2.48   10 0.784 0.577 0.92, 7.99 -0.57
PERA/EiJ f 16.2 2.25   5 1.0 0.139 13.4, 19.5 0.93
PERA/EiJ m 11.9 1.22   9 0.408 0.103 9.79, 13.5 1.09
RIIIS/J f 7.79 2.02   8 0.713 0.259 4.28, 9.94 -0.44
RIIIS/J m 6.02 2.37   8 0.839 0.394 1.91, 9.25 -0.19
SEA/GnJ f 6.92 6.07   8 2.14 0.876 0.54, 15.5 -0.59
SEA/GnJ m 6.22 4.92   8 1.74 0.792 1.43, 13.0 -0.15
SM/J f 17.7 1.75   8 0.619 0.0989 15.6, 19.6 1.17
SM/J m 9.65 5.54   8 1.96 0.574 3.13, 17.0 0.6


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 4.6513 1.1721 6.9582 2.3443
129S1/SvImJ m 1.75 1.1721 4.057 0.0
A/J f 1.6687 1.1721 3.9757 0.0
A/J m 3.3 1.1721 5.607 0.993
BALB/cByJ f 13.1688 1.1721 15.4757 10.8618
BALB/cByJ m 9.8563 1.1721 12.1632 7.5493
BTBR T+ Itpr3tf/J f 2.4338 1.1721 4.7407 0.1268
BTBR T+ Itpr3tf/J m 0.8887 1.1721 3.1957 0.0
BUB/BnJ f 3.1167 1.9141 6.884 0.0
BUB/BnJ m 2.2786 1.253 4.7449 0.0
C57BL/6J f 19.9625 1.1721 22.2695 17.6555
C57BL/6J m 14.775 1.1721 17.082 12.468
C57BLKS/J f 15.775 1.1721 18.082 13.468
C57BLKS/J m 11.1286 1.253 13.5949 8.6623
C58/J f 18.275 1.1721 20.582 15.968
C58/J m 13.75 1.253 16.2163 11.2837
CZECHII/EiJ f 13.5933 1.9141 17.3606 9.826
CZECHII/EiJ m 0.8283 1.3534 3.4922 0.0
DBA/2J f 1.2886 1.253 3.7549 0.0
DBA/2J m 0.5862 1.1721 2.8932 0.0
FVB/NJ f 16.6357 1.253 19.102 14.1694
FVB/NJ m 11.7687 1.1721 14.0757 9.4618
I/LnJ f 17.325 1.1721 19.632 15.018
I/LnJ m 10.81 1.1721 13.117 8.503
LP/J f 2.3675 1.1721 4.6745 0.0605
LP/J m 3.96 1.1721 6.267 1.653
MA/MyJ f 11.5287 1.1721 13.8357 9.2218
MA/MyJ m 5.9713 1.1721 8.2782 3.6643
NOD/ShiLtJ f 12.11 1.1721 14.417 9.803
NOD/ShiLtJ m 8.555 1.1721 10.862 6.248
NON/ShiLtJ f 8.8729 1.253 11.3391 6.4066
NON/ShiLtJ m 2.315 1.1721 4.622 0.008
NZB/BlNJ f 12.535 1.1721 14.842 10.228
NZB/BlNJ m 11.0262 1.1721 13.3332 8.7193
NZW/LacJ f 7.28 1.3534 9.9439 4.6161
NZW/LacJ m 4.299 1.0484 6.3624 2.2356
PERA/EiJ f 16.22 1.4826 19.1381 13.3019
PERA/EiJ m 11.8767 1.1051 14.0517 9.7016
RIIIS/J f 7.7875 1.1721 10.0945 5.4805
RIIIS/J m 6.02 1.1721 8.327 3.713
SEA/GnJ f 6.925 1.1721 9.232 4.618
SEA/GnJ m 6.2187 1.1721 8.5257 3.9118
SM/J f 17.7125 1.1721 20.0195 15.4055
SM/J m 9.6487 1.1721 11.9557 7.3418


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 3.2006 0.8288 4.8319 1.5693
A/J both 2.4844 0.8288 4.1157 0.8531
BALB/cByJ both 11.5125 0.8288 13.1438 9.8812
BTBR T+ Itpr3tf/J both 1.6613 0.8288 3.2925 0.03
BUB/BnJ both 2.6976 1.1439 4.949 0.4462
C57BL/6J both 17.3688 0.8288 19.0 15.7375
C57BLKS/J both 13.4518 0.8579 15.1403 11.7632
C58/J both 16.0125 0.8579 17.7011 14.3239
CZECHII/EiJ both 7.2108 1.1721 9.5178 4.9038
DBA/2J both 0.9374 0.8579 2.626 0.0
FVB/NJ both 14.2022 0.8579 15.8908 12.5137
I/LnJ both 14.0675 0.8288 15.6988 12.4362
LP/J both 3.1638 0.8288 4.795 1.5325
MA/MyJ both 8.75 0.8288 10.3813 7.1187
NOD/ShiLtJ both 10.3325 0.8288 11.9638 8.7012
NON/ShiLtJ both 5.5939 0.8579 7.2825 3.9054
NZB/BlNJ both 11.7806 0.8288 13.4119 10.1493
NZW/LacJ both 5.7895 0.856 7.4743 4.1047
PERA/EiJ both 14.0483 0.9246 15.8681 12.2285
RIIIS/J both 6.9038 0.8288 8.535 5.2725
SEA/GnJ both 6.5719 0.8288 8.2032 4.9406
SM/J both 13.6806 0.8288 15.3119 12.0493




  GWAS USING LINEAR MIXED MODELS