Metten1: Drug study: Assessment of ethanol-induced intoxication using a standard rating scale, in 9 inbred strains of mice (2004)

Metten P, Best KL, Cameron AJ, Saultz AB, Zuraw JM, Yu CH, Wahlsten D, Crabbe JC. Observer-rated ataxia: Rating scales for assessment of genetic differences in ethanol-induced intoxication in mice. J Appl Physiol. 2004 Jul;97(1):360-8. Epub 2004 Mar 19.   PubMed 15033960  

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Participants Pamela Metten       Oregon Health & Science University,  Portland, OR
John C Crabbe       Oregon Health & Science University,  Portland, OR
Douglas Wahlsten       University of Windsor,  Windsor, Ontario CANADA
With: Best KL, Cameron AJ, Saultz AB, Zuraw JM, Yu C-H
ContactPamela Metten
AcknowledgementsFunding provided by NIH AA10760, AA12714, AA13519; Department of Veterans Affairs.

Acknowledgments: Schlumbohm JP, Cotnam CJ, Forster A for technical assistance.
Project type Phenotype strain survey data set
MPD identifiersMetten1     MPD:165
Data changelog No updates/corrections.       Initial release date: 01/2007.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
An investigation of mechanisms underlying ethanol-induced intoxication. Animals were scored using an observation-based rating scale of ataxia in combination with automated assessment of activity and motor function in an open field. Animals were measured at baseline and then again following ethanol administration at one of two randomly-assigned doses: (1) EtOH 2.75 g/kg body weight i.p.; (2) EtOH 3.0 g/kg body weight i.p.

Summary of procedures that were conducted
• behavior observation Observed gait, hindlimb splay 10 min and 30 min after ethanol i.p. (several doses).
• open field test Locomotor activity. Ethanol i.p. (several doses) vs. control (saline i.p.). 45s test.
Mice: inbred   9 strains   ♀♂   age 8-11wks   1 cohort