MPD: Phenotype measures mapped to VT:0002139, hepatobiliary system physiology trait

Phenotype measures associated with ontology term
VT:0002139 'hepatobiliary system physiology trait'

All measures in this list are mapped to the ontology descendants of VT:0002139. None are mapped to VT:0002139 directly.

VT:0000609 liver physiology trait
VT:0003893 hepatocyte proliferation trait

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)	Year

Harrill1:26	Harrill1	lipid profile	isoniazid	hepatic cholesterol (CHOL) [mg/dL] liver_CHOL 39526 control isoniazid	inbred	34	f	8-10wks	N=4	2011

Harrill1:31	Harrill1	lipid profile	isoniazid	hepatic triglycerides (TG) [mg/dL] liver_TG 39531 control isoniazid	inbred	34	f	8-10wks	N=4	2011

Paigen1:26	Paigen1	lipid profile	high-fat diet	hepatic cholesterol concentration (free per g liver) [mg] freeHCC 2926	inbred	43	both	15-19wks	N=6	2000

Paigen1:27	Paigen1	lipid profile	high-fat diet	hepatic cholesterol concentration (esterified per g liver) [mg] estHCC 2927	inbred	43	both	15-19wks	N=6	2000

Paigen1:28	Paigen1	lipid profile	high-fat diet	hepatic cholesterol concentration (total per g liver) [mg] totHCC 2928	inbred	43	both	15-19wks	N=8	2000

Paigen1:29	Paigen1	lipid profile	high-fat diet	hepatic cholesterol concentration (free to esterified ratio) [ratio] free_to_est 2929	inbred	43	both	15-19wks	N=6	2000

Paigen3:26	Paigen3	lipid profile	high-fat diet	hepatic cholesterol concentration (free per g liver) [mg] freeHCC 2826	obesity mutants	8	both	15-19wks	N=6	2000

Paigen3:27	Paigen3	lipid profile	high-fat diet	hepatic cholesterol concentration (esterified per g liver) [mg] estHCC 2827	obesity mutants	8	both	15-19wks	N=6	2000

Paigen3:28	Paigen3	lipid profile	high-fat diet	hepatic cholesterol concentration (total per g liver) [mg] totHCC 2828	obesity mutants	8	both	15-19wks	N=9	2000

Paigen3:29	Paigen3	lipid profile	high-fat diet	hepatic cholesterol concentration (free to esterified ratio) [ratio] free_to_est 2829	obesity mutants	8	both	15-19wks	N=6	2000

Rusyn5:21	Rusyn5	lipid profile	high-fat diet and ethanol	hepatic triglycerides (TG) [mg/g] liver_TG 43021 high-fat only high-fat and ethanol	inbred	6	m	8-14wks	N=3	2011

Rusyn5:23	Rusyn5	metabolite quantification	high-fat diet and ethanol	reduced liver glutathione (GSH) [nmol/mg] liver_GSH 43023 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:25	Rusyn5	metabolite quantification	high-fat diet and ethanol	oxidized liver glutathione (GSSG) [nmol/mg] liver_GSSG 43025 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:29	Rusyn5	metabolite quantification	high-fat diet and ethanol	ratio of reduced to oxidized liver glutathione [ratio] liver_GSHratio 43029 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:31	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver homocysteine [nmol/mg] liver_homocysteine 43031 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:33	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver S-adenosylhomocysteine (SAH) [nmol/mg] liver_SAH 43033 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:35	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver methionine [nmol/mg] liver_methionine 43035 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:37	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver S-adenosylmethionine (SAM) [nmol/mg] liver_SAM 43037 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:39	Rusyn5	metabolite quantification	high-fat diet and ethanol	ratio of liver SAM to SAH (SAM/SAH) [ratio] liver_SAM_SAH 43039 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:42	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver BHMT, protein expression relative to high-fat-only group [%] liver_BHMT_hfe 43042	inbred	14	m	8-14wks	N=3	2011

Rusyn5:44	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver DDIT3 (formerly CHOP), protein expression relative to high-fat-only group [%] liver_DDIT3_hfe 43044	inbred	14	m	8-14wks	N=3	2011

Rusyn5:46	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver HSPA5 (formerly GRP78), protein expression relative to high-fat-only group [%] liver_HSPA5_hfe 43046	inbred	14	m	8-14wks	N=3	2011

Rusyn5:48	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver SREBF1 (formerly NSREBP1), protein expression relative to high-fat-only group [%] liver_SREBF1_hfe 43048	inbred	14	m	8-14wks	N=3	2011

Rusyn5:50	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Acox1, mRNA abundance relative to high-fat-only group [%] liver_Acox1_hfe 43050	inbred	6	m	8-14wks	N=3	2011

Rusyn5:52	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Adipor2, mRNA abundance relative to high-fat-only group [%] liver_Adipor2_hfe 43052	inbred	6	m	8-14wks	N=3	2011

Rusyn5:54	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Ahcy, mRNA abundance relative to high-fat-only group [%] liver_Ahcy_hfe 43054	inbred	14	m	8-14wks	N=3	2011

Rusyn5:56	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Cbs, mRNA abundance relative to high-fat-only group [%] liver_Cbs_hfe 43056	inbred	14	m	8-14wks	N=3	2011

Rusyn5:58	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Cebpa, mRNA abundance relative to high-fat-only group [%] liver_Cebpa_hfe 43058	inbred	14	m	8-14wks	N=3	2011

Rusyn5:60	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Cth, mRNA abundance relative to high-fat-only group [%] liver_Cth_hfe 43060	inbred	14	m	8-14wks	N=3	2011

Rusyn5:62	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Ddit3 (formerly Chop), mRNA abundance relative to high-fat-only group [%] liver_Ddit3_hfe 43062	inbred	14	m	8-14wks	N=3	2011

Rusyn5:64	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Gnmt, mRNA abundance relative to high-fat-only group [%] liver_Gnmt_hfe 43064	inbred	14	m	8-14wks	N=3	2011

Rusyn5:66	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Mat1a, mRNA abundance relative to high-fat-only group [%] liver_Mat1a_hfe 43066	inbred	14	m	8-14wks	N=3	2011

Rusyn5:68	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Mthfr, mRNA abundance relative to high-fat-only group [%] liver_Mthfr_hfe 43068	inbred	14	m	8-14wks	N=3	2011

Rusyn5:70	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Mtr, mRNA abundance relative to high-fat-only group [%] liver_Mtr_hfe 43070	inbred	14	m	8-14wks	N=3	2011

Rusyn5:72	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Mttp, mRNA abundance relative to high-fat-only group [%] liver_Mttp_hfe 43072	inbred	6	m	8-14wks	N=3	2011

Rusyn5:74	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Srebf1, mRNA abundance relative to high-fat-only group [%] liver_Srebf1_hfe 43074	inbred	14	m	8-14wks	N=3	2011

Rusyn6:14	Rusyn6	histopathology	trichloroethylene	BrdU-positive nuclei in liver (hepatocellular proliferation), relative to control group [%] BrdU_liver_tce 51214	inbred	7	m	6-7wks	N=3	2014

Rusyn6:26	Rusyn6	RNA expression profiling	trichloroethylene	Acox1, mRNA in liver, relative to control group [ratio] Acox1_liver_tce 51226	inbred	7	m	6-7wks	N=3	2014

Rusyn6:28	Rusyn6	RNA expression profiling	trichloroethylene	Cyp4a10, mRNA in liver, relative to control group [ratio] Cyp4a10_liver_tce 51228	inbred	7	m	6-7wks	N=3	2014

Rusyn6:30	Rusyn6	RNA expression profiling	trichloroethylene	Ppara, mRNA in liver, relative to control group [ratio] Ppara_liver_tce 51230	inbred	7	m	6-7wks	N=3	2014

Schonfeld1:22	Schonfeld1	lipid profile	(none)	hepatic triglycerides (5h fast) [mg/g] hTG 32348	inbred	11	both	9-13wks	N=6	2005

Sunde1:11	Sunde1	RNA expression profiling	selenium	liver Dio1, mRNA abundance relative to C57BL/6J +Se [%] Dio1_mRNA 65311 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:13	Sunde1	RNA expression profiling	selenium	liver Gpx1, mRNA abundance relative to C57BL/6J +Se [%] Gpx1_mRNA 65313 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:15	Sunde1	RNA expression profiling	selenium	liver Gpx3, mRNA abundance relative to C57BL/6J +Se [%] Gpx3_mRNA 65315 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:17	Sunde1	RNA expression profiling	selenium	liver Gpx4, mRNA abundance relative to C57BL/6J +Se [%] Gpx4_mRNA 65317 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:19	Sunde1	RNA expression profiling	selenium	liver Msrb1, mRNA abundance relative to C57BL/6J +Se [%] Msrb1_mRNA 65319 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:21	Sunde1	RNA expression profiling	selenium	liver Selenof, mRNA abundance relative to C57BL/6J +Se [%] Selenof_mRNA 65321 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:23	Sunde1	RNA expression profiling	selenium	liver Selenoh, mRNA abundance relative to C57BL/6J +Se [%] Selenoh_mRNA 65323 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:25	Sunde1	RNA expression profiling	selenium	liver Selenok, mRNA abundance relative to C57BL/6J +Se [%] Selenok_mRNA 65325 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:27	Sunde1	RNA expression profiling	selenium	liver Selenom, mRNA abundance relative to C57BL/6J +Se [%] Selenom_mRNA 65327 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:29	Sunde1	RNA expression profiling	selenium	liver Selenon, mRNA abundance relative to C57BL/6J +Se [%] Selenon_mRNA 65329 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:31	Sunde1	RNA expression profiling	selenium	liver Selenoo, mRNA abundance relative to C57BL/6J +Se [%] Selenoo_mRNA 65331 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:33	Sunde1	RNA expression profiling	selenium	liver Selenop, mRNA abundance relative to C57BL/6J +Se [%] Selenop_mRNA 65333 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:35	Sunde1	RNA expression profiling	selenium	liver Selenos, mRNA abundance relative to C57BL/6J +Se [%] Selenos_mRNA 65335 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:37	Sunde1	RNA expression profiling	selenium	liver Selenot, mRNA abundance relative to C57BL/6J +Se [%] Selenot_mRNA 65337 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:39	Sunde1	RNA expression profiling	selenium	liver Selenow, mRNA abundance relative to C57BL/6J +Se [%] Selenow_mRNA 65339 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:41	Sunde1	RNA expression profiling	selenium	liver Txnrd1, mRNA abundance relative to C57BL/6J +Se [%] Txnrd1_mRNA 65341 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:43	Sunde1	RNA expression profiling	selenium	liver Txnrd2, mRNA abundance relative to C57BL/6J +Se [%] Txnrd2_mRNA 65343 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:45	Sunde1	RNA expression profiling	selenium	liver Txnrd3, mRNA abundance relative to C57BL/6J +Se [%] Txnrd3_mRNA 65345 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:47	Sunde1	protein activity assessment	selenium	liver Gpx1 enzyme activity (EU/g protein) [EU/g] Gpx1_act_liv 65347 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:53	Sunde1	protein activity assessment	selenium	liver Gpx4 enzyme activity (EU/g protein) [EU/g] Gpx4_act 65353 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Sunde1:55	Sunde1	protein activity assessment	selenium	liver Txnrd enzyme activity (EU/g protein) [EU/g] Txnrd_act 65355 Se deficient Se sufficient	inbred w/CC8	8	m	11-14wks	N=1	2018

Threadgill1:14	Threadgill1	metabolite quantification	acetaminophen	reduced glutathione (GSH) [µmol/g] GSH 19414 control post-Rx 300mg/kg	inbred w/CC7	36	m	8-17wks	N=2	2005

Threadgill1:16	Threadgill1	metabolite quantification	acetaminophen	oxidized glutathione (GSSG) [µmol/g] GSSG 19416 control post-Rx 300mg/kg	inbred w/CC7	36	m	8-17wks	N=2	2005

Threadgill1:18	Threadgill1	metabolite quantification	acetaminophen	total glutathione (GSH plus GSSG) [µmol/g] GSH_total 19418 control post-Rx 300 mg/kg	inbred w/CC7	36	m	8-17wks	N=2	2005

Threadgill1:20	Threadgill1	metabolite quantification	acetaminophen	ratio of reduced (GSH) to oxidized (GSSG) glutathione [ratio] GSHratio 19420 control post-Rx 300mg/kg	inbred w/CC7	36	m	8-17wks	N=2	2005

Threadgill1:82	Threadgill1	metabolic panel	acetaminophen	catalase [µg/mL] catalase 19482 control post-Rx 300 mg/kg	inbred w/CC7	37	m	8-12wks	N=2	2005

Threadgill1:83	Threadgill1	biomarker quantification	acetaminophen	cytochrome P450 1A2 isoform [pmol/mg] CYP1A2 19483 control post-Rx 300 mg/kg	inbred w/CC7	37	m	8-12wks	N=2	2005

Threadgill1:84	Threadgill1	biomarker quantification	acetaminophen	cytochrome P450 2E1 isoform [pmol/mg] CYP2E1 19484 control post-Rx 300 mg/kg	inbred w/CC7	37	m	8-12wks	N=2	2005

Threadgill1:86	Threadgill1	metabolite quantification	acetaminophen	glutathione transferase [µg/mL] GSTpi 19486 control post-Rx 300 mg/kg	inbred w/CC7	37	m	8-12wks	N=2	2005

Threadgill2:5	Threadgill2	metabolite quantification	acetaminophen	reduced glutathione (GSH) [µmol/mg] GSH 39605 control post-Rx 300 mg/kg	inbred	5	m	6-8wks	N=4	2005

Threadgill2:6	Threadgill2	metabolite quantification	acetaminophen	percent reduced glutathione [%] GSH_pct 39606 control post-Rx 300 mg/kg	inbred	5	m	6-8wks	N=4	2005

Threadgill2:7	Threadgill2	metabolite quantification	acetaminophen	total glutathione [µmol/mg] GSH_total 39607 control post-Rx 300 mg/kg	inbred	5	m	6-8wks	N=4	2005

Vulpe1:1	Vulpe1	mineral quantification	(none)	copper (Cu) content in liver, dry weight [µg/g] copper 36801	inbred	18	both	8wks	N=6	2010

Vulpe1:2	Vulpe1	mineral quantification	(none)	iron (Fe) content in liver, dry weight [µg/g] iron 36802	inbred	18	both	8wks	N=6	2010

Vulpe1:3	Vulpe1	mineral quantification	(none)	zinc (Zn) content in liver, dry weight [µg/g] zinc 36803	inbred	18	both	8wks	N=6	2010

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