Chesler2: Multi-system assessment of 8 inbred founder strains and 54 F1 hybrids of the Collaborative Cross (2011)

Philip VM, Sokoloff G, Ackert-Bicknell CL, Striz M, Branstetter L, Beckmann MA, Spence JS, Jackson BL, Galloway LD, Barker P, Wymore AM, Hunsicker PR, Durtschi DC, Chesler EJ, et al. Genetic analysis in the Collaborative Cross breeding population. Genome Res. 2011 Aug;21(8):1223-38. Epub 2011 Jul 6.   PubMed 21734011     FullText

Chesler2 downloads
• Download Chesler2 project data set     one row per animal, one column per trait
• Download Chesler2 strain means, SD, N, etc.     one row per strain/sex/measure
Participants Elissa J Chesler       The Jackson Laboratory Bar Harbor, ME
Vivek M Philip       The Jackson Laboratory Bar Harbor, ME
Brynn H Voy       University of Tennessee Knoxville, TN
With: Sokoloff G, Ackert-Bicknell C, Striz M, Churchill GA, Lariviere WR, Palmer AA, OHara BF
ContactElissa J Chesler     Lab web site
Part of a series: • F1s with progenitors   (this project) Chesler2
• pre-CC lines w/ progenitors   see Chesler3
AcknowledgementsFunding provided by NIH DA021198, MH079103, AG025707; FA9550-05-1-0464; US Department of Energy, University of Tennessee Health Science Center, Oak Ridge National Laboratory, The Jackson Laboratory, The Ellison Medical Foundation
Project type Phenotype strain survey data set
MPD identifiersChesler2     MPD:434
Data changelog 1 update/correction.       Initial release date: 12/2012.
Formatted citation
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An assessment of F1 hybrids bred from the 8 CC founder strains. Data for the founder strains are also present.

Summary of procedures that were conducted
• metabolic panel Clinical blood chemistry. 16h fast.
• complete blood count Hematology.
• colony observation Reproduction, fecundity.
• open field test Locomotor activity, exploratory, anxiety-related behavior. 10 min test.
• light-dark box Anxiety, avoidance behavior. 10 min test.
• behavior observation Wildness scoring.
• nociception assay Hot plate and pressure on tail.
• monitoring system Sleep patterns. Dark period, total, peak activity. Baseline and after sleep deprivation.
• body size and weight Body weight, body length, tail length.
• fat pad weights Gonadal fat pad weight.
• organ weights Heart, kidney weights.
Mice: CC diallel w/par   62 strains   ♀♂   age 7-15wks   1 cohort