Chesler2: Multi-system assessment of 8 inbred founder strains and 54 F1 hybrids of the Collaborative Cross (2011)

Philip VM, Sokoloff G, Ackert-Bicknell CL, Striz M, Branstetter L, Beckmann MA, Spence JS, Jackson BL, Galloway LD, Barker P, Wymore AM, Hunsicker PR, Durtschi DC, Chesler EJ, et al. Genetic analysis in the Collaborative Cross breeding population. Genome Res. 2011 Aug;21(8):1223-38. Epub 2011 Jul 6.   PubMed 21734011     FullText


       
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Participants Elissa J Chesler       The Jackson Laboratory Bar Harbor, ME
Vivek M Philip       The Jackson Laboratory Bar Harbor, ME
Brynn H Voy       University of Tennessee Knoxville, TN
With: Sokoloff G, Ackert-Bicknell C, Striz M, Churchill GA, Lariviere WR, Palmer AA, OHara BF
ContactElissa J Chesler     elissa.chesler@jax.org     Lab web site
Part of a series: • F1s with progenitors   (this project) Chesler2
• pre-CC lines w/ progenitors   see Chesler3
AcknowledgementsFunding provided by NIH DA021198, MH079103, AG025707; FA9550-05-1-0464; US Department of Energy, University of Tennessee Health Science Center, Oak Ridge National Laboratory, The Jackson Laboratory, The Ellison Medical Foundation
Project type Phenotype strain survey data set
MPD identifiersChesler2     MPD:434
Data changelog 1 update/correction.       Initial release date: 12/2012.
Formatted citation
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An assessment of F1 hybrids bred from the 8 CC founder strains. Data for the founder strains are also present.

Summary of procedures that were conducted
• metabolic panel Clinical blood chemistry. 16h fast.
• complete blood count Hematology.
• colony observation Reproduction, fecundity.
• open field test Locomotor activity, exploratory, anxiety-related behavior. 10 min test.
• light-dark box Anxiety, avoidance behavior. 10 min test.
• behavior observation Wildness scoring.
• nociception assay Hot plate and pressure on tail.
• monitoring system Sleep patterns. Dark period, total, peak activity. Baseline and after sleep deprivation.
• body size and weight Body weight, body length, tail length.
• fat pad weights Gonadal fat pad weight.
• organ weights Heart, kidney weights.
Mice: CC diallel w/par   62 strains   ♀♂   age 7-15wks   1 cohort

Select table page: First Prev Next Last
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Chesler2 43401 metabolic panel (none) sodium (blood Na)   [mmol/L]  sodium CC diallel w/par 35 both 7-15wks N=2
    Chesler2 43402 metabolic panel (none) potassium (blood K)   [mmol/L]  potassium CC diallel w/par 35 both 7-15wks N=2
    Chesler2 43403 metabolic panel (none) chloride (blood Cl)   [mmol/L]  chloride CC diallel w/par 35 both 7-15wks N=2
    Chesler2 43404 metabolic panel (none) calcium (blood ionized Ca)   [mmol/L]  calcium CC diallel w/par 35 both 7-15wks N=2
    Chesler2 43405 metabolic panel (none) anion gap concentration (mEq/L)   [mmol/L]  anion_gap CC diallel w/par 35 both 7-15wks N=2
    Chesler2 43406 metabolic panel (none) carbon dioxide (blood CO2)   [mmol/L]  carbon_dioxide CC diallel w/par 35 both 7-15wks N=2
    Chesler2 43407 metabolic panel (none) glucose (blood GLU, no fast)   [mg/dL]  GLU CC diallel w/par 35 both 7-15wks N=2
    Chesler2 43408 metabolic panel (none) glucose (blood GLU, 16h fast)   [mg/dL]  GLU_fast CC diallel w/par 40 both 7-15wks N=3
    Chesler2 43409 metabolic panel (none) blood urea nitrogen (BUN)   [mg/dL]  BUN CC diallel w/par 35 both 7-15wks N=2
    Chesler2 43410 metabolic panel (none) creatinine (blood)   [mg/dL]  creatinine CC diallel w/par 35 both 7-15wks N=2
    Chesler2 43413 complete blood count (none) white blood cell count (WBC; units per volume x 103)   [n/µL]  WBC CC diallel w/par 38 both 7-15wks N=2
    Chesler2 43414 complete blood count (none) lymphocyte count (LYM; units per volume x 103)   [n/µL]  LYM CC diallel w/par 38 both 7-15wks N=2
    Chesler2 43415 complete blood count (none) lymphocyte differential (LYM; percent of viable WBC)   [%]  pct_LYM CC diallel w/par 38 both 7-15wks N=2
    Chesler2 43416 complete blood count (none) monocyte count (MONO; units per volume x 103)   [n/µL]  MONO CC diallel w/par 38 both 7-15wks N=2
    Chesler2 43417 complete blood count (none) monocyte differential (MONO; percent of viable WBC)   [%]  pct_MONO CC diallel w/par 38 both 7-15wks N=2
    Chesler2 43418 complete blood count (none) granulocyte count (GRA; units per volume x 103)   [n/µL]  GRA CC diallel w/par 38 both 7-15wks N=2
    Chesler2 43419 complete blood count (none) granulocyte differential (GRA; percent of total viable WBC)   [%]  pct_GRA CC diallel w/par 38 both 7-15wks N=2
    Chesler2 43420 complete blood count (none) eosinophil differential (EOS; percent of viable WBC)   [%]  pct_EOS CC diallel w/par 38 both 7-15wks N=2
    Chesler2 43421 complete blood count (none) red blood cell count (RBC; units per volume x 106)   [n/µL]  RBC CC diallel w/par 38 both 7-15wks N=2
    Chesler2 43422 complete blood count (none) mean RBC corpuscular volume (MCV)   [fL]  MCV CC diallel w/par 38 both 7-15wks N=2
    Chesler2 43423 complete blood count (none) RBC corpuscular distribution width (RDW)   [%]  RDW CC diallel w/par 38 both 7-15wks N=2
    Chesler2 43424 complete blood count (none) mean RBC corpuscular hemoglobin (MCH)   [pg]  MCH CC diallel w/par 38 both 7-15wks N=2
    Chesler2 43425 complete blood count (none) mean RBC corpuscular hemoglobin concentration (MCHC)   [g/dL]  MCHC CC diallel w/par 38 both 7-15wks N=2
    Chesler2 43426 complete blood count (none) hemoglobin (HGB)   [g/dL]  hemoglobin CC diallel w/par 38 both 7-15wks N=2
    Chesler2 43427 complete blood count (none) hematocrit (HCT)   [%]  hematocrit CC diallel w/par 38 both 7-15wks N=2
    Chesler2 43428 complete blood count (none) platelet count (PLT; units per volume x 103)   [n/µL]  platelets CC diallel w/par 38 both 7-15wks N=2
    Chesler2 43429 complete blood count (none) mean platelet volume (MPV)   [fL]  MPV CC diallel w/par 38 both 7-15wks N=2
    Chesler2 43441 colony observation (none) number of mice born in first litter   [n]  litter_size CC diallel w/par 62 both 4wks N=8
    Chesler2 43442 colony observation (none) parental age at first litter   [d]  age_first_litter CC diallel w/par 62 both 4wks N=8
    Chesler2 43443 colony observation (none) time from mate to first litter   [d]  duration_to_litter CC diallel w/par 62 both 4wks N=8
    Chesler2 43451 open field test (none) distance traveled during first 3 min, 10 min test   [cm]  distance3_OFT CC diallel w/par 41 both 7-15wks N=2
    Chesler2 43452 open field test (none) distance traveled, 10 min test   [cm]  distance10_OFT CC diallel w/par 41 both 7-15wks N=2
    Chesler2 43453 open field test (none) number of transitions between center and periphery, 10 min test   [n]  transitions_OFT CC diallel w/par 41 both 7-15wks N=2
    Chesler2 43454 open field test (none) time spent in center during first minute, 10 min test   [s]  center1_OFT CC diallel w/par 41 both 7-15wks N=2
    Chesler2 43455 open field test (none) time spent in center, 10 min test   [s]  center10_OFT CC diallel w/par 41 both 7-15wks N=2
    Chesler2 43456 open field test (none) integrated distance from absolute center, 10 min test   [cm]  distance_center_OFT CC diallel w/par 41 both 7-15wks N=2
    Chesler2 43457 open field test (none) percentage of time in center, 10 min test   [%]  pct_center_OFT CC diallel w/par 41 both 7-15wks N=2
    Chesler2 43458 open field test (none) latency to reach periphery, 10 min test   [s]  latency_periphery_OFT CC diallel w/par 41 both 7-15wks N=2
    Chesler2 43459 open field test (none) time spent in periphery, 10 min test   [s]  duration_periphery_OFT CC diallel w/par 41 both 7-15wks N=2
    Chesler2 43460 open field test (none) time spent immobile during first minute, 10 min test   [s]  immobile_OFT CC diallel w/par 41 both 7-15wks N=2
    Chesler2 43461 open field test (none) number of fecal boli, 10 min test   [n]  fecal_boli_OFT CC diallel w/par 40 both 7-15wks N=2
    Chesler2 43462 open field test (none) number of urine puddles, 10 min test   [n]  urination_OFT CC diallel w/par 40 both 7-15wks N=2
    Chesler2 43463 light-dark box (none) time spent in light compartment, 10 min test   [s]  duration_light_LD CC diallel w/par 39 both 7-15wks N=2
    Chesler2 43464 light-dark box (none) distance traveled in light compartment, 10 min test   [cm]  distance_light_LD CC diallel w/par 39 both 7-15wks N=2
    Chesler2 43465 light-dark box (none) percentage of time in light compartment, 10 min test   [%]  pct_light_LD CC diallel w/par 39 both 7-15wks N=2
    Chesler2 43466 light-dark box (none) latency to enter dark compartment, 10 min test   [s]  latency_dark_LD CC diallel w/par 39 both 7-15wks N=2
    Chesler2 43467 light-dark box (none) number of transitions between light and dark compartments, 10 min test   [n]  transitions_LD CC diallel w/par 39 both 7-15wks N=2
    Chesler2 43468 light-dark box (none) number of fecal boli, 10 min test   [n]  fecal_boli_LD CC diallel w/par 39 both 7-15wks N=2
    Chesler2 43469 light-dark box (none) number of urine puddles, 10 min test   [n]  urination_LD CC diallel w/par 39 both 7-15wks N=2
    Chesler2 43470 behavior observation (none) response to capture   [score]  capture_score CC diallel w/par 62 both 7-15wks N=8
    Chesler2 43471 behavior observation (none) response to holding   [score]  hold_score CC diallel w/par 62 both 7-15wks N=8
    Chesler2 43472 behavior observation (none) capture and hold scores combined   [score]  wildness_score CC diallel w/par 62 both 7-15wks N=8
    Chesler2 43473 nociception assay (none) latency of nociceptive response to pressure on the tail, 60 s test   [s]  tail_clip CC diallel w/par 48 both 7-15wks N=3
    Chesler2 43474 nociception assay (none) latency of nociceptive response to hot plate (54°C), 30 s test   [s]  hot_plate CC diallel w/par 48 both 7-15wks N=3
    Chesler2 43481 monitoring system (none) percentage of time spent sleeping, baseline   [%]  pct_sleep_daily CC diallel w/par 51 both 7-15wks N=3
    Chesler2 43482 monitoring system (none) percentage of time spent sleeping during dark period, baseline   [%]  pct_sleep_dark CC diallel w/par 51 both 7-15wks N=3
    Chesler2 43483 monitoring system (none) percentage of time spent sleeping, following sleep deprivation   [%]  pct_daily_deprivation CC diallel w/par 48 both 7-15wks N=2
    Chesler2 43484 monitoring system (none) percentage of time spent sleeping during dark period, following sleep deprivation   [%]  pct_dark_deprivation CC diallel w/par 48 both 7-15wks N=2
    Chesler2 43485 monitoring system (none) peak activity time from dark onset, following sleep deprivation   [h]  act_dark_deprivation CC diallel w/par 48 both 7-15wks N=2
    Chesler2 43486 body size and weight (none) body weight   [g]  body_weight CC diallel w/par 54 both 7-15wks N=3
    Chesler2 43488 body size and weight (none) tail length   [cm]  tail_length CC diallel w/par 41 both 7-15wks N=3
    Chesler2 43489 fat pad weights (none) gonadal fat pad weight   [g]  gonad_fat_wt CC diallel w/par 39 both 7-15wks N=3
    Chesler2 43492 organ weights (none) heart weight   [g]  heart_wt CC diallel w/par 40 both 7-15wks N=3
    Chesler2 43496 organ weights (none) kidney (left) weight   [g]  kidneyL_wt CC diallel w/par 40 both 7-15wks N=3
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