Phenotype measure:   Chesler2   tail_clip

ID, description, units MPD:43473   tail_clip   latency of nociceptive response to pressure on the tail, 60 s test   [s]
Data set, strains Chesler2   CC diallel w/par   48 strains     sex: both     age: 7-15wks
Procedure nociception assay
Ontology mappings

  STRAIN COMPARISON PLOT
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Chesler2 - latency of nociceptive response to pressure on the tail, 60 s test



  8-WAY DIALLEL CROSS VIEW
Female animals
129S ♂ A ♂ B6 ♂ CAST ♂ NOD ♂ NZO ♂ PWK ♂ WSB ♂
129S ♀ 42.7 20.1 30.1 29.5 30.3 46.5 19.0
A ♀ 38.4 30.9 35.1 35.8 40.5
B6 ♀ 46.2 60.0 28.2 34.2 9.91 42.5 45.2
CAST ♀ 36.2 35.2 10.5 36.7 33.6 14.4 21.4
NOD ♀ 43.2 51.2 16.6 28.4 36.5
NZO ♀ 24.2 30.6 42.3 38.3 11.9
PWK ♀ 39.9 60.0 2.68 19.4
WSB ♀ 23.4 30.2 30.4 60.0 21.7 60.0 1.54

Male animals
129S ♂ A ♂ B6 ♂ CAST ♂ NOD ♂ NZO ♂ PWK ♂ WSB ♂
129S ♀ 60.0 42.3 38.4 36.1 24.4 39.8
A ♀ 52.7 54.8 41.3 37.9 6.96 34.2 60.0
B6 ♀ 51.0 25.5 34.5 45.6 25.7 22.0
CAST ♀ 18.8 47.4 25.0 27.9 22.4 7.96 13.8
NOD ♀ 60.0 29.9 29.5 31.5 60.0 15.9 31.3
NZO ♀ 60.0 54.2 18.6 31.9
PWK ♀ 34.9 13.7 21.4 24.8
WSB ♀ 16.3 19.8 29.1 9.54 11.7 27.6 39.6

Cell coloring is based on strain mean Z-scores.     High-end         Mid         Low-end           Mouse over the cells to see additional info.


  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested47 strains48 strains
Mean of the strain means32.5   s 32.7   s
Median of the strain means33.6   s 30.6   s
SD of the strain means± 14.3 ± 15.3
Coefficient of variation (CV)0.441 0.467
Min–max range of strain means1.54   –   60.0   s 6.96   –   60.0   s
Mean sample size per strain3.0   mice 3.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 273.2315 273.2315 1.0485 0.3076
strain 27 25113.6663 930.1358 3.5693 < 0.0001
sex:strain 27 11863.5473 439.3906 1.6861 0.027
Residuals 144 37524.9796 260.5901


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129SAF1 f 42.7 18.9   3 10.9 0.443 22.5, 60.0 0.72
129SAF1 m 60.0 0.0   7 0.0 0.0 60.0, 60.0 1.79
129SB6F1 f 20.1 17.3   3 9.97 0.861 5.96, 39.3 -0.86
129SB6F1 m 42.3 19.9   5 8.88 0.47 13.2, 60.0 0.63
129SCASTF1 f 30.1 27.4   2   19.3 0.91 10.7, 49.4 -0.16
129SNODF1 f 29.5 0.0   1   0.0 0.0 29.5, 29.5 -0.21
129SNODF1 m 38.4 30.5   2   21.6 0.793 16.9, 60.0 0.38
129SNZOF1 f 30.3 14.8   2   10.4 0.486 19.9, 40.8 -0.15
129SNZOF1 m 36.1 16.1   5 7.22 0.447 17.0, 60.0 0.23
129SPWKF1 f 46.5 15.6   4 7.79 0.335 32.9, 60.0 0.98
129SPWKF1 m 24.4 7.55   2   5.34 0.31 19.1, 29.7 -0.54
129SWSBF1 f 19.0 16.6   4 8.31 0.876 1.32, 41.1 -0.94
129SWSBF1 m 39.8 26.8   3 15.5 0.673 9.43, 60.0 0.47
AB6F1 f 38.4 7.57   3 4.37 0.197 33.3, 47.1 0.42
AB6F1 m 54.8 7.03   5 3.14 0.128 44.1, 60.0 1.45
ACASTF1 f 30.9 8.61   4 4.3 0.279 23.4, 39.9 -0.11
ACASTF1 m 41.3 23.3   4 11.7 0.564 7.84, 60.0 0.57
A/J m 52.7 14.7   4 7.34 0.279 30.6, 60.0 1.31
ANODF1 f 35.1 0.0   1   0.0 0.0 35.1, 35.1 0.18
ANODF1 m 37.9 21.2   9 7.07 0.56 2.59, 60.0 0.34
ANZOF1 f 35.8 15.9   11 4.79 0.444 4.35, 60.0 0.23
ANZOF1 m 6.96 0.0354   2   0.025 0.00508 6.93, 6.98 -1.68
APWKF1 f 40.5 19.7   2   13.9 0.486 26.6, 54.4 0.56
APWKF1 m 34.2 17.8   4 8.9 0.521 19.2, 60.0 0.1
AWSBF1 m 60.0 0.0   1   0.0 0.0 60.0, 60.0 1.79
B6129SF1/J f 46.2 23.9   3 13.8 0.519 18.5, 60.0 0.96
B6AF1/J f 60.0 0.0   2   0.0 0.0 60.0, 60.0 1.93
B6AF1/J m 51.0 15.6   3 8.99 0.305 33.0, 60.0 1.2
B6CASTF1 f 28.2 23.9   4 11.9 0.846 2.42, 60.0 -0.3
B6CASTF1 m 34.5 0.0   1   0.0 0.0 34.5, 34.5 0.12
B6NODF1 f 34.2 14.0   2   9.87 0.408 24.3, 44.0 0.12
B6NODF1 m 45.6 6.63   2   4.69 0.146 40.9, 50.3 0.85
B6NZOF1 f 9.91 8.92   3 5.15 0.899 1.74, 19.4 -1.58
B6NZOF1 m 25.7 4.32   2   3.06 0.168 22.6, 28.8 -0.46
B6PWKF1 f 42.5 24.7   2   17.5 0.582 25.0, 60.0 0.7
B6WSBF1 f 45.2 17.5   6 7.13 0.386 18.6, 60.0 0.89
B6WSBF1 m 22.0 4.83   3 2.79 0.219 16.6, 25.7 -0.7
C57BL/6J m 25.5 15.0   3 8.64 0.587 8.83, 37.8 -0.47
CAST129SF1 m 18.8 19.7   7 7.46 1.05 3.46, 60.0 -0.91
CASTAF1 f 36.2 33.7   2   23.8 0.933 12.3, 60.0 0.26
CASTAF1 m 47.4 3.1   2   2.2 0.0655 45.2, 49.6 0.97
CASTB6F1 f 35.2 0.0   1   0.0 0.0 35.2, 35.2 0.19
CASTB6F1 m 25.0 15.0   3 8.68 0.6 9.37, 39.3 -0.5
CAST/EiJ f 10.5 7.03   5 3.14 0.67 2.28, 18.1 -1.53
CAST/EiJ m 27.9 8.87   2   6.27 0.318 21.7, 34.2 -0.31
CASTNODF1 f 36.7 32.9   2   23.3 0.895 13.5, 60.0 0.3
CASTNODF1 m 22.4 16.3   6 6.67 0.731 6.94, 50.2 -0.67
CASTNZOF1 f 33.6 25.5   4 12.7 0.758 1.3, 60.0 0.08
CASTNZOF1 m 7.96 0.0   1   0.0 0.0 7.96, 7.96 -1.62
CASTPWKF1 f 14.4 25.6   5 11.4 1.78 1.59, 60.0 -1.26
CASTPWKF1 m 13.8 15.2   6 6.19 1.1 1.66, 41.9 -1.24
CASTWSBF1 f 21.4 26.8   2   18.9 1.25 2.47, 40.4 -0.77
NOD129SF1 m 60.0 0.0   1   0.0 0.0 60.0, 60.0 1.79
NODAF1 f 43.2 0.0   1   0.0 0.0 43.2, 43.2 0.75
NODAF1 m 29.9 10.9   2   7.7 0.364 22.2, 37.6 -0.18
NODB6F1 f 51.2 15.3   4 7.66 0.299 28.4, 60.0 1.31
NODB6F1 m 29.5 8.93   2   6.32 0.302 23.2, 35.8 -0.21
NODCASTF1 f 16.6 10.5   5 4.7 0.632 1.36, 28.0 -1.11
NODCASTF1 m 31.5 18.6   2   13.1 0.59 18.4, 44.6 -0.08
NODNZOF1 f 28.4 17.9   3 10.3 0.63 8.82, 43.8 -0.28
NODNZOF1 m 15.9 12.4   3 7.14 0.778 5.06, 29.4 -1.1
NODPWKF1 f 36.5 2.66   2   1.88 0.0727 34.7, 38.4 0.28
NODPWKF1 m 31.3 24.4   8 8.62 0.779 5.46, 60.0 -0.09
NOD/ShiLtJ m 60.0 0.0   1   0.0 0.0 60.0, 60.0 1.79
NZO129SF1 f 24.2 8.32   2   5.88 0.343 18.4, 30.1 -0.58
NZO129SF1 m 60.0 0.0   1   0.0 0.0 60.0, 60.0 1.79
NZOAF1 f 30.6 22.4   4 11.2 0.732 7.99, 60.0 -0.13
NZOB6F1 f 42.3 15.1   8 5.34 0.357 22.7, 60.0 0.69
NZOB6F1 m 54.2 8.24   2   5.83 0.152 48.4, 60.0 1.41
NZO/HlLtJ m 31.9 0.0   1   0.0 0.0 31.9, 31.9 -0.05
NZONODF1 f 38.3 8.44   3 4.87 0.221 30.0, 46.9 0.41
NZONODF1 m 18.6 15.6   3 9.04 0.84 2.23, 33.4 -0.92
NZOWSBF1 f 11.9 4.65   3 2.69 0.39 7.1, 16.4 -1.44
PWK129SF1 f 39.9 23.8   5 10.6 0.596 2.22, 60.0 0.52
PWKAF1 f 60.0 0.0   2   0.0 0.0 60.0, 60.0 1.93
PWKAF1 m 34.9 1.15   2   0.81 0.0328 34.1, 35.7 0.15
PWKB6F1 f 2.68 0.0   1   0.0 0.0 2.68, 2.68 -2.08
PWKB6F1 m 13.7 17.7   2   12.5 1.29 1.17, 26.2 -1.24
PWKNODF1 f 19.4 0.0   1   0.0 0.0 19.4, 19.4 -0.91
PWKNODF1 m 21.4 12.2   2   8.61 0.569 12.8, 30.0 -0.74
PWK/PhJ m 24.8 0.219   2   0.155 0.00882 24.7, 25.0 -0.52
WSB129SF1 f 23.4 15.5   4 7.76 0.663 9.24, 37.0 -0.63
WSB129SF1 m 16.3 16.8   2   11.9 1.03 4.42, 28.1 -1.07
WSBAF1 f 30.2 0.0   1   0.0 0.0 30.2, 30.2 -0.16
WSBAF1 m 19.8 8.61   2   6.09 0.435 13.7, 25.9 -0.84
WSBB6F1 f 30.4 5.78   2   4.09 0.191 26.3, 34.5 -0.14
WSBB6F1 m 29.1 17.2   3 9.91 0.59 10.9, 45.0 -0.23
WSBCASTF1 m 9.54 10.3   4 5.16 1.08 1.45, 23.9 -1.52
WSB/EiJ f 1.54 0.184   2   0.13 0.119 1.41, 1.67 -2.16
WSB/EiJ m 39.6 9.45   2   6.69 0.239 32.9, 46.3 0.45
WSBNODF1 f 60.0 0.0   1   0.0 0.0 60.0, 60.0 1.93
WSBNODF1 m 11.7 3.63   2   2.56 0.311 9.09, 14.2 -1.37
WSBNZOF1 f 21.7 20.1   6 8.21 0.928 2.15, 60.0 -0.75
WSBNZOF1 m 27.6 22.4   4 11.2 0.81 8.84, 60.0 -0.33
WSBPWKF1 f 60.0 0.0   3 0.0 0.0 60.0, 60.0 1.93


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129SAF1 f 42.6733 9.3201 61.0951 24.2515
129SAF1 m 60.0 6.1014 72.0599 47.9401
129SB6F1 f 20.05 9.3201 38.4718 1.6282
129SB6F1 m 42.264 7.2193 56.5335 27.9945
129SNZOF1 f 30.33 11.4147 52.892 7.768
129SNZOF1 m 36.07 7.2193 50.3395 21.8005
129SPWKF1 f 46.51 8.0714 62.4637 30.5563
129SPWKF1 m 24.39 11.4147 46.952 1.828
129SWSBF1 f 18.955 8.0714 34.9087 3.0013
129SWSBF1 m 39.8133 9.3201 58.2351 21.3915
AB6F1 f 38.4133 9.3201 56.8351 19.9915
AB6F1 m 54.768 7.2193 69.0375 40.4985
ACASTF1 f 30.8575 8.0714 46.8112 14.9038
ACASTF1 m 41.305 8.0714 57.2587 25.3513
ANZOF1 f 35.7936 4.8672 45.4141 26.1732
ANZOF1 m 6.955 11.4147 29.517 0.0
APWKF1 f 40.5 11.4147 63.062 17.938
APWKF1 m 34.1675 8.0714 50.1212 18.2138
B6AF1/J f 60.0 11.4147 82.562 37.438
B6AF1/J m 51.0133 9.3201 69.4351 32.5915
B6NODF1 f 34.18 11.4147 56.742 11.618
B6NODF1 m 45.58 11.4147 68.142 23.018
B6NZOF1 f 9.9133 9.3201 28.3351 0.0
B6NZOF1 m 25.695 11.4147 48.257 3.133
B6WSBF1 f 45.1983 6.5903 58.2245 32.1722
B6WSBF1 m 22.03 9.3201 40.4518 3.6082
CASTAF1 f 36.155 11.4147 58.717 13.593
CASTAF1 m 47.425 11.4147 69.987 24.863
CAST/EiJ f 10.484 7.2193 24.7535 0.0
CAST/EiJ m 27.945 11.4147 50.507 5.383
CASTNODF1 f 36.745 11.4147 59.307 14.183
CASTNODF1 m 22.355 6.5903 35.3812 9.3288
CASTPWKF1 f 14.404 7.2193 28.6735 0.1345
CASTPWKF1 m 13.805 6.5903 26.8312 0.7788
NODB6F1 f 51.1875 8.0714 67.1412 35.2338
NODB6F1 m 29.525 11.4147 52.087 6.963
NODCASTF1 f 16.636 7.2193 30.9055 2.3665
NODCASTF1 m 31.475 11.4147 54.037 8.913
NODNZOF1 f 28.36 9.3201 46.7818 9.9382
NODNZOF1 m 15.89 9.3201 34.3118 0.0
NODPWKF1 f 36.55 11.4147 59.112 13.988
NODPWKF1 m 31.285 5.7073 42.566 20.004
NZOB6F1 f 42.3487 5.7073 53.6297 31.0678
NZOB6F1 m 54.175 11.4147 76.737 31.613
NZONODF1 f 38.28 9.3201 56.7018 19.8582
NZONODF1 m 18.6333 9.3201 37.0551 0.2115
PWKAF1 f 60.0 11.4147 82.562 37.438
PWKAF1 m 34.91 11.4147 57.472 12.348
WSB129SF1 f 23.4225 8.0714 39.3762 7.4688
WSB129SF1 m 16.28 11.4147 38.842 0.0
WSBB6F1 f 30.36 11.4147 52.922 7.798
WSBB6F1 m 29.08 9.3201 47.5018 10.6582
WSB/EiJ f 1.54 11.4147 24.102 0.0
WSB/EiJ m 39.595 11.4147 62.157 17.033
WSBNZOF1 f 21.6717 6.5903 34.6978 8.6455
WSBNZOF1 m 27.6025 8.0714 43.5562 11.6488


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129SAF1 both 51.3367 5.5698 62.3458 40.3275
129SB6F1 both 31.157 5.8945 42.808 19.506
129SNZOF1 both 33.2 6.753 46.5479 19.8521
129SPWKF1 both 35.45 6.99 49.2663 21.6337
129SWSBF1 both 29.3842 6.1646 41.569 17.1993
AB6F1 both 46.5907 5.8945 58.2416 34.9397
ACASTF1 both 36.0812 5.7073 47.3622 24.8003
ANZOF1 both 21.3743 6.2045 33.638 9.1106
APWKF1 both 37.3337 6.99 51.1501 23.5174
B6AF1/J both 55.5067 7.3681 70.0704 40.943
B6NODF1 both 39.88 8.0714 55.8337 23.9263
B6NZOF1 both 17.8042 7.3681 32.3679 3.2405
B6WSBF1 both 33.6142 5.7073 44.8952 22.3332
CASTAF1 both 41.79 8.0714 57.7437 25.8363
CAST/EiJ both 19.2145 6.753 32.5624 5.8666
CASTNODF1 both 29.55 6.5903 42.5762 16.5238
CASTPWKF1 both 14.1045 4.8875 23.765 4.444
NODB6F1 both 40.3563 6.99 54.1726 26.5399
NODCASTF1 both 24.0555 6.753 37.4034 10.7076
NODNZOF1 both 22.125 6.5903 35.1512 9.0988
NODPWKF1 both 33.9175 6.381 46.53 21.305
NZOB6F1 both 48.2619 6.381 60.8744 35.6493
NZONODF1 both 28.4567 6.5903 41.4828 15.4305
PWKAF1 both 47.455 8.0714 63.4087 31.5013
WSB129SF1 both 19.8512 6.99 33.6676 6.0349
WSBB6F1 both 29.72 7.3681 44.2837 15.1563
WSB/EiJ both 20.5675 8.0714 36.5212 4.6138
WSBNZOF1 both 24.6371 5.2101 34.9352 14.339




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA