Chesler3: Multi-system assessment of 8 inbred founder strains and 360+ emerging lines (pre-CC) of the Collaborative Cross (2011)

Philip VM, Sokoloff G, Ackert-Bicknell CL, Striz M, Branstetter L, Beckmann MA, Spence JS, Jackson BL, Galloway LD, Barker P, Wymore AM, Hunsicker PR, Durtschi DC, Chesler EJ, et al. Genetic analysis in the Collaborative Cross breeding population. Genome Res. 2011 Aug;21(8):1223-38. Epub 2011 Jul 6.   PubMed 21734011     FullText

Chesler3 downloads
• Download Chesler3 project data set     one row per animal, one column per trait
• Download Chesler3 strain means, SD, N, etc.     one row per strain/sex/measure
Participants Elissa J Chesler       The Jackson Laboratory Bar Harbor, ME
Vivek M Philip       The Jackson Laboratory Bar Harbor, ME
Brynn H Voy       University of Tennessee Knoxville, TN
With: Sokoloff G, Ackert-Bicknell C, Striz M, Churchill GA, Lariviere WR, Palmer AA, OHara BF
ContactElissa J Chesler     Lab web site
Part of a series: • F1s with progenitors   see Chesler2
• pre-CC lines w/ progenitors   (this project) Chesler3
AcknowledgementsFunding provided by NIH DA021198, MH079103, AG025707; FA9550-05-1-0464; US Department of Energy, University of Tennessee Health Science Center, Oak Ridge National Laboratory, The Jackson Laboratory, The Ellison Medical Foundation
Project type Phenotype strain survey data set
MPD identifiersChesler3     MPD:435
Data changelog 2 updates/corrections.       Initial release date: 12/2012.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
An assessment of emerging CC lines. Generations range from G2:F5 to G2:F9. Data for the 8 founder strains are also present.

Summary of procedures that were conducted
• metabolic panel Clinical blood chemistry. 16h fast.
• complete blood count Hematology.
• colony observation Reproduction, fecundity.
• open field test Locomotor activity, exploratory, anxiety-related behavior. 10 min test.
• light-dark box Anxiety, avoidance behavior. 10 min test.
• behavior observation Wildness scoring.
• nociception assay Hot plate and pressure on tail.
• monitoring system Sleep patterns. Dark period, total, peak activity. Baseline and after sleep deprivation.
• body size and weight Body weight, tail length.
• fat pad weights Gonadal fat pad weights.
• bone dimensions Femur.
• organ weights Heart, brain, kidney, spleen, gonadal fat pads, testicle weights.
• organ dimensions Kidney length and volume.
Mice: CC pre w/par   367 strains   ♀♂   age 7-15wks   1 cohort