Chesler3: Multi-system assessment of 8 inbred founder strains and 360+ emerging lines (pre-CC) of the Collaborative Cross (2011)

Philip VM, Sokoloff G, Ackert-Bicknell CL, Striz M, Branstetter L, Beckmann MA, Spence JS, Jackson BL, Galloway LD, Barker P, Wymore AM, Hunsicker PR, Durtschi DC, Chesler EJ, et al. Genetic analysis in the Collaborative Cross breeding population. Genome Res. 2011 Aug;21(8):1223-38. Epub 2011 Jul 6.   PubMed 21734011     FullText

Chesler3 downloads
• Download Chesler3 project data set     animal data, as uploaded
• Download Chesler3 animal data matrix     with factor-related expansion applied as necessary
• Download Chesler3 strain means, SD, N, etc.     one row per strain/sex/measure
Ontology terms mapped to Chesler3 measures:
    MA:0000008   tail
    MA:0000059   blood
    MA:0000072   heart
    MA:0000141   spleen
    MA:0000168   brain
    MA:0000326   reproductive system
    MA:0000368   kidney
    MA:0001359   femur
    MA:0002501   plasma
    MA:0002547   gonadal fat pad
    MP:0000188   abnormal circulating glucose level
    MP:0000217   abnormal leukocyte cell number
    MP:0000226   abnormal mean corpuscular volume
    MP:0000559   abnormal femur morphology
    MP:0000717   abnormal lymphocyte cell number
    MP:0000771   abnormal brain size
    MP:0001256   abnormal body length
    MP:0001259   abnormal body weight
    MP:0001362   abnormal anxiety-related response
    MP:0001392   abnormal locomotor behavior
    MP:0001562   abnormal circulating calcium level
    MP:0001586   abnormal erythrocyte cell number
    MP:0001588   abnormal hemoglobin
    MP:0001589   abnormal mean corpuscular hemoglobin
    MP:0001761   abnormal urination pattern
    MP:0001776   abnormal circulating sodium level
    MP:0002061   abnormal aggression-related behavior
    MP:0002161   abnormal fertility/fecundity
    MP:0002586   abnormal platelet volume
    MP:0002596   abnormal hematocrit
    MP:0002602   abnormal eosinophil cell number
    MP:0002668   abnormal circulating potassium level
    MP:0002706   abnormal kidney size
    MP:0002707   abnormal kidney weight
    MP:0002733   abnormal thermal nociception
    MP:0002734   abnormal mechanical nociception
    MP:0003018   abnormal circulating chloride level
    MP:0003860   abnormal carbon dioxide level
    MP:0004214   abnormal long bone diaphysis morphology
    MP:0004850   abnormal testis weight
    MP:0004857   abnormal heart weight
    MP:0004951   abnormal spleen weight
    MP:0005265   abnormal blood urea nitrogen level
    MP:0005328   abnormal circulating creatinine level
    MP:0005335   abnormal gonadal fat pad morphology
    MP:0005640   abnormal mean corpuscular hemoglobin concentration
    MP:0006357   abnormal circulating mineral level
    MP:0010066   abnormal red blood cell distribution width
    MP:0011396   abnormal sleep behavior
    MP:0011898   abnormal platelet cell number
    MP:0011999   abnormal tail length
    MP:0012441   abnormal monocyte cell number
    MP:0013189   abnormal exploration in a new environment
    MP:0020147   abnormal defecation amount
    MP:0020201   abnormal granulocyte number
    MP:0020467   abnormal circadian behavior
    VT:0000068   blood mineral amount
    VT:0000188   blood glucose amount
    VT:0000217   leukocyte quantity
    VT:0000223   monocyte quantity
    VT:0000248   erythrocyte size trait
    VT:0000334   granulocyte quantity
    VT:0000689   spleen morphology trait
    VT:0000717   lymphocyte quantity
    VT:0001256   body length
    VT:0001259   body mass
    VT:0001392   locomotor behavior trait
    VT:0001501   sleep behavior trait
    VT:0001502   behavioral circadian rhythm trait
    VT:0001562   blood calcium amount
    VT:0001586   erythrocyte quantity
    VT:0001588   blood hemoglobin amount
    VT:0001776   blood sodium amount
    VT:0001922   male fertility trait
    VT:0001923   female fertility trait
    VT:0001970   pain threshold
    VT:0002161   female fecundity trait
    VT:0002176   brain mass
    VT:0002329   blood gas amount
    VT:0002447   erythrocyte morphology trait
    VT:0002602   eosinophil quantity
    VT:0002668   blood potassium amount
    VT:0002706   kidney size trait
    VT:0002707   kidney mass
    VT:0002733   thermal nociception trait
    VT:0002734   mechanical nociception trait
    VT:0002758   tail length
    VT:0003018   blood chloride amount
    VT:0003179   platelet quantity
    VT:0003620   urine output
    VT:0004152   blood iron amount
    VT:0004951   spleen mass
    VT:0005265   blood urea nitrogen amount
    VT:0005328   blood creatinine amount
    VT:0005335   gonadal fat pad morphology trait
    VT:0005452   adipose amount
    VT:0007028   heart mass
    VT:0010014   femur circumference
    VT:0010457   platelet size trait
    VT:0010461   excretion behavior trait
    VT:0010462   defecation behavior trait
    VT:0010464   fertility trait
    VT:0010471   exploratory behavior trait
    VT:0010716   anxiety-related behavior trait
    VT:0010726   wildness behavior trait
    VT:0015014   aggression-related behavior trait
    VT:1000189   offspring quantity
    VT:1000644   testis mass
Investigators Elissa J Chesler       The Jackson Laboratory,  Bar Harbor, ME
Vivek M Philip       The Jackson Laboratory,  Bar Harbor, ME
Brynn H Voy       University of Tennessee,  Knoxville, TN
Participants Sokoloff G, Ackert-Bicknell C, Striz M, Churchill GA, Lariviere WR, Palmer AA, OHara BF
ContactElissa J Chesler     Lab web site
Part of a series: • F1s with progenitors   see Chesler2
• pre-CC lines w/ progenitors   (this project) Chesler3
AcknowledgementsFunding provided by NIH DA021198, MH079103, AG025707; FA9550-05-1-0464; US Department of Energy, University of Tennessee Health Science Center, Oak Ridge National Laboratory, The Jackson Laboratory, The Ellison Medical Foundation
Project type Phenotype strain survey data set
MPD identifiersChesler3     MPD:435
Data changelog 2 updates/corrections.       Initial release date: 12/2012.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
An assessment of emerging CC lines. Generations range from G2:F5 to G2:F9. Data for the 8 founder strains are also present.

Procedures conducted:
• metabolic panel  Clinical blood chemistry. 16h fast.
• complete blood count  Hematology.
• colony observation  Reproduction, fecundity.
• open field test  Locomotor activity, exploratory, anxiety-related behavior. 10 min test.
• light-dark box  Anxiety, avoidance behavior. 10 min test.
• behavior observation  Wildness scoring.
• nociception assay  Hot plate and pressure on tail.
• monitoring system  Sleep patterns. Dark period, total, peak activity. Baseline and after sleep deprivation.
• body size and weight  Body weight, tail length.
• fat pad weights  Gonadal fat pad weights.
• bone dimensions  Femur.
• organ weights  Heart, brain, kidney, spleen, gonadal fat pads, testicle weights.
• organ dimensions  Kidney length and volume.

Mice: CC pre w/par   395 strains   ♀♂   age 7-15wks   1 experimental group