Phenotype measure:   Chesler2   hot_plate

ID, description, units MPD:43474   hot_plate   latency of nociceptive response to hot plate (54°C), 30 s test   [s]
Data set, strains Chesler2   CC diallel w/par   48 strains     sex: both     age: 7-15wks
Procedure nociception assay
Ontology mappings

  STRAIN COMPARISON PLOT
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Chesler2 - latency of nociceptive response to hot plate (54°C), 30 s test



  8-WAY DIALLEL CROSS VIEW
Female animals
129S ♂ A ♂ B6 ♂ CAST ♂ NOD ♂ NZO ♂ PWK ♂ WSB ♂
129S ♀ 4.98 3.68 4.83 3.69 4.22 5.87 4.12
A ♀ 5.37 5.28 4.45 5.09 9.33
B6 ♀ 4.99 4.61 5.61 3.90 5.09 4.98 6.22
CAST ♀ 4.38 3.37 3.59 4.61 3.48 5.97 4.64
NOD ♀ 4.33 5.71 3.70 4.42 5.78
NZO ♀ 3.70 4.88 5.03 5.25 3.76
PWK ♀ 6.09 5.86 3.98 6.83
WSB ♀ 5.04 3.96 4.50 4.36 3.76 4.93 7.13

Male animals
129S ♂ A ♂ B6 ♂ CAST ♂ NOD ♂ NZO ♂ PWK ♂ WSB ♂
129S ♀ 5.99 4.91 3.56 4.82 5.04 4.61
A ♀ 8.60 6.07 6.46 4.44 4.17 6.86 4.10
B6 ♀ 4.56 6.59 4.04 5.57 4.89 6.57
CAST ♀ 4.25 3.42 3.77 6.94 4.51 3.62 6.78
NOD ♀ 4.74 4.03 5.43 3.55 2.97 3.60 5.08
NZO ♀ 7.28 4.41 6.23 4.79
PWK ♀ 5.01 4.45 3.94 6.75
WSB ♀ 4.12 4.55 5.13 4.71 4.89 3.77 7.84

Cell coloring is based on strain mean Z-scores.     High-end         Mid         Low-end           Mouse over the cells to see additional info.


  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested47 strains48 strains
Mean of the strain means4.88   s 5.05   s
Median of the strain means4.83   s 4.77   s
SD of the strain means± 1.11 ± 1.27
Coefficient of variation (CV)0.228 0.252
Min–max range of strain means3.37   –   9.33   s 2.97   –   8.60   s
Mean sample size per strain3.0   mice 2.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 4.6235 4.6235 2.0593 0.1535
strain 27 174.5538 6.465 2.8794 < 0.0001
sex:strain 27 46.9114 1.7375 0.7739 0.7787
Residuals 143 321.0652 2.2452


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129SAF1 f 4.98 1.4   3 0.81 0.282 3.93, 6.57 0.09
129SAF1 m 5.99 3.1   7 1.17 0.517 3.38, 12.6 0.74
129SB6F1 f 3.68 0.266   3 0.154 0.0724 3.49, 3.98 -1.08
129SB6F1 m 4.91 2.03   5 0.907 0.413 3.02, 8.15 -0.11
129SCASTF1 f 4.83 1.42   2   1.0 0.294 3.83, 5.83 -0.04
129SNODF1 f 3.69 0.0   1   0.0 0.0 3.69, 3.69 -1.07
129SNODF1 m 3.56 0.93   2   0.657 0.261 2.9, 4.22 -1.17
129SNZOF1 f 4.22 0.725   2   0.512 0.172 3.71, 4.73 -0.59
129SNZOF1 m 4.82 1.34   4 0.669 0.278 2.99, 5.9 -0.18
129SPWKF1 f 5.87 1.56   4 0.781 0.266 3.71, 7.41 0.89
129SPWKF1 m 5.04 0.269   2   0.19 0.0533 4.86, 5.24 -0.01
129SWSBF1 f 4.12 1.06   4 0.531 0.258 3.17, 5.61 -0.68
129SWSBF1 m 4.61 0.642   3 0.371 0.139 4.06, 5.32 -0.35
AB6F1 f 5.37 2.18   3 1.26 0.407 3.21, 7.58 0.44
AB6F1 m 6.07 0.473   5 0.212 0.078 5.62, 6.66 0.8
ACASTF1 f 5.28 0.79   4 0.395 0.15 4.33, 6.17 0.36
ACASTF1 m 6.46 2.14   4 1.07 0.331 4.21, 9.25 1.11
A/J m 8.6 5.22   4 2.61 0.607 4.68, 16.1 2.78
ANODF1 f 4.45 0.0   1   0.0 0.0 4.45, 4.45 -0.39
ANODF1 m 4.44 1.45   9 0.482 0.325 2.87, 7.16 -0.48
ANZOF1 f 5.09 1.66   11 0.501 0.326 3.44, 9.14 0.19
ANZOF1 m 4.17 0.909   2   0.643 0.218 3.52, 4.81 -0.69
APWKF1 f 9.33 0.0813   2   0.0575 0.00872 9.27, 9.38 4.0
APWKF1 m 6.86 1.66   4 0.83 0.242 4.78, 8.62 1.42
AWSBF1 m 4.1 0.0   1   0.0 0.0 4.1, 4.1 -0.75
B6129SF1/J f 4.99 0.873   3 0.504 0.175 4.16, 5.9 0.1
B6AF1/J f 4.61 0.909   2   0.643 0.197 3.97, 5.25 -0.24
B6AF1/J m 4.56 0.6   3 0.347 0.132 3.97, 5.17 -0.38
B6CASTF1 f 5.61 1.17   4 0.583 0.208 4.16, 6.81 0.66
B6CASTF1 m 4.04 0.0   1   0.0 0.0 4.04, 4.04 -0.79
B6NODF1 f 3.9 1.2   2   0.85 0.309 3.04, 4.75 -0.88
B6NODF1 m 5.57 0.516   2   0.365 0.0927 5.21, 5.93 0.41
B6NZOF1 f 5.09 1.68   3 0.968 0.329 3.85, 7.0 0.19
B6NZOF1 m 4.89 0.552   2   0.39 0.113 4.5, 5.28 -0.13
B6PWKF1 f 4.98 0.315   2   0.223 0.0632 4.75, 5.2 0.09
B6WSBF1 f 6.22 1.57   6 0.64 0.252 4.71, 8.78 1.2
B6WSBF1 m 6.57 1.0   3 0.579 0.153 5.61, 7.61 1.19
C57BL/6J m 6.59 0.334   3 0.193 0.0507 6.22, 6.88 1.21
CAST129SF1 m 4.25 0.439   7 0.166 0.103 3.48, 4.89 -0.63
CASTAF1 f 4.38 1.07   2   0.758 0.245 3.62, 5.13 -0.45
CASTAF1 m 3.42 0.53   2   0.375 0.155 3.04, 3.79 -1.28
CASTB6F1 f 3.37 0.0   1   0.0 0.0 3.37, 3.37 -1.36
CASTB6F1 m 3.77 0.946   3 0.546 0.251 2.7, 4.5 -1.0
CAST/EiJ f 3.59 0.968   5 0.433 0.27 2.59, 4.94 -1.16
CAST/EiJ m 6.94 0.813   2   0.575 0.117 6.36, 7.51 1.48
CASTNODF1 f 4.61 0.894   2   0.633 0.194 3.98, 5.24 -0.24
CASTNODF1 m 4.51 1.88   6 0.768 0.417 3.12, 8.07 -0.42
CASTNZOF1 f 3.48 0.55   4 0.275 0.158 2.97, 4.08 -1.26
CASTNZOF1 m 3.62 0.0   1   0.0 0.0 3.62, 3.62 -1.12
CASTPWKF1 f 5.97 2.09   5 0.937 0.351 3.29, 8.9 0.98
CASTPWKF1 m 6.78 1.72   6 0.703 0.254 4.63, 9.56 1.36
CASTWSBF1 f 4.64 0.099   2   0.07 0.0213 4.58, 4.71 -0.22
NOD129SF1 m 4.74 0.0   1   0.0 0.0 4.74, 4.74 -0.24
NODAF1 f 4.33 0.0   1   0.0 0.0 4.33, 4.33 -0.49
NODAF1 m 4.03 1.7   2   1.2 0.422 2.83, 5.24 -0.8
NODB6F1 f 5.71 1.77   4 0.885 0.31 4.37, 8.29 0.75
NODB6F1 m 5.43 1.08   2   0.765 0.199 4.66, 6.19 0.3
NODCASTF1 f 3.7 0.233   5 0.104 0.0628 3.45, 4.07 -1.06
NODCASTF1 m 3.55 0.099   2   0.07 0.0278 3.48, 3.62 -1.18
NODNZOF1 f 4.42 0.468   3 0.27 0.106 3.98, 4.92 -0.41
NODNZOF1 m 3.6 0.479   3 0.277 0.133 3.25, 4.15 -1.14
NODPWKF1 f 5.78 1.75   2   1.24 0.303 4.54, 7.02 0.81
NODPWKF1 m 5.08 1.11   8 0.393 0.219 3.75, 6.58 0.02
NOD/ShiLtJ m 2.97 0.0   1   0.0 0.0 2.97, 2.97 -1.63
NZO129SF1 f 3.7 0.00354   2   0.0025 0.000955 3.7, 3.71 -1.06
NZO129SF1 m 7.28 0.0   1   0.0 0.0 7.28, 7.28 1.75
NZOAF1 f 4.88 0.91   4 0.455 0.186 3.79, 5.88 0.0
NZOB6F1 f 5.03 1.23   8 0.435 0.245 3.87, 7.51 0.13
NZOB6F1 m 4.41 1.36   2   0.965 0.309 3.44, 5.38 -0.5
NZO/HlLtJ m 4.79 0.0   1   0.0 0.0 4.79, 4.79 -0.2
NZONODF1 f 5.25 1.33   3 0.765 0.253 4.29, 6.76 0.33
NZONODF1 m 6.23 2.64   3 1.52 0.424 4.7, 9.27 0.93
NZOWSBF1 f 3.76 0.575   3 0.332 0.153 3.23, 4.37 -1.01
PWK129SF1 f 6.09 0.702   5 0.314 0.115 5.21, 7.09 1.09
PWKAF1 f 5.86 2.8   2   1.98 0.478 3.88, 7.84 0.88
PWKAF1 m 5.01 1.13   2   0.8 0.226 4.21, 5.81 -0.03
PWKB6F1 f 3.98 0.0   1   0.0 0.0 3.98, 3.98 -0.81
PWKB6F1 m 4.45 0.75   2   0.53 0.169 3.92, 4.97 -0.47
PWKNODF1 f 6.83 0.0   1   0.0 0.0 6.83, 6.83 1.75
PWKNODF1 m 3.94 0.343   2   0.242 0.087 3.7, 4.18 -0.87
PWK/PhJ m 6.75 0.424   2   0.3 0.0629 6.45, 7.04 1.33
WSB129SF1 f 5.04 1.93   4 0.963 0.382 3.69, 7.89 0.14
WSB129SF1 m 4.12 0.339   2   0.24 0.0825 3.88, 4.36 -0.73
WSBAF1 f 3.96 0.0   1   0.0 0.0 3.96, 3.96 -0.83
WSBAF1 m 4.55 1.15   2   0.81 0.251 3.75, 5.37 -0.39
WSBB6F1 f 4.5 0.513   2   0.362 0.114 4.13, 4.86 -0.34
WSBB6F1 m 5.13 0.849   3 0.49 0.165 4.46, 6.08 0.06
WSBCASTF1 m 4.71 0.363   4 0.182 0.0771 4.21, 5.05 -0.27
WSB/EiJ f 7.13 1.35   3 0.778 0.189 5.58, 8.0 2.02
WSB/EiJ m 7.84 0.385   2   0.273 0.0491 7.57, 8.12 2.19
WSBNODF1 f 4.36 0.0   1   0.0 0.0 4.36, 4.36 -0.47
WSBNODF1 m 4.89 0.877   2   0.62 0.179 4.28, 5.51 -0.13
WSBNZOF1 f 3.76 0.808   6 0.33 0.215 2.62, 4.78 -1.01
WSBNZOF1 m 3.77 0.329   3 0.19 0.0873 3.42, 4.08 -1.0
WSBPWKF1 f 4.93 0.0889   3 0.0513 0.0181 4.83, 5.0 0.05


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129SAF1 f 4.9767 0.8651 6.6867 3.2666
129SAF1 m 5.9936 0.5663 7.1131 4.8741
129SB6F1 f 3.675 0.8651 5.385 1.965
129SB6F1 m 4.91 0.6701 6.2346 3.5854
129SNZOF1 f 4.2175 1.0595 6.3119 2.1231
129SNZOF1 m 4.815 0.7492 6.2959 3.3341
129SPWKF1 f 5.865 0.7492 7.3459 4.3841
129SPWKF1 m 5.045 1.0595 7.1394 2.9506
129SWSBF1 f 4.12 0.7492 5.6009 2.6391
129SWSBF1 m 4.6083 0.8651 6.3184 2.8983
AB6F1 f 5.3683 0.8651 7.0784 3.6583
AB6F1 m 6.066 0.6701 7.3906 4.7414
ACASTF1 f 5.2813 0.7492 6.7622 3.8003
ACASTF1 m 6.455 0.7492 7.9359 4.9741
ANZOF1 f 5.0877 0.4518 5.9808 4.1947
ANZOF1 m 4.1675 1.0595 6.2619 2.0731
APWKF1 f 9.3275 1.0595 11.4219 7.2331
APWKF1 m 6.8625 0.7492 8.3434 5.3816
B6AF1/J f 4.6125 1.0595 6.7069 2.5181
B6AF1/J m 4.5567 0.8651 6.2667 2.8466
B6NODF1 f 3.895 1.0595 5.9894 1.8006
B6NODF1 m 5.57 1.0595 7.6644 3.4756
B6NZOF1 f 5.0933 0.8651 6.8034 3.3833
B6NZOF1 m 4.89 1.0595 6.9844 2.7956
B6WSBF1 f 6.225 0.6117 7.4342 5.0158
B6WSBF1 m 6.565 0.8651 8.275 4.855
CASTAF1 f 4.3775 1.0595 6.4719 2.2831
CASTAF1 m 3.415 1.0595 5.5094 1.3206
CAST/EiJ f 3.59 0.6701 4.9146 2.2654
CAST/EiJ m 6.935 1.0595 9.0294 4.8406
CASTNODF1 f 4.6075 1.0595 6.7019 2.5131
CASTNODF1 m 4.5108 0.6117 5.72 3.3017
CASTPWKF1 f 5.971 0.6701 7.2956 4.6464
CASTPWKF1 m 6.7767 0.6117 7.9858 5.5675
NODB6F1 f 5.7075 0.7492 7.1884 4.2266
NODB6F1 m 5.425 1.0595 7.5194 3.3306
NODCASTF1 f 3.702 0.6701 5.0266 2.3774
NODCASTF1 m 3.555 1.0595 5.6494 1.4606
NODNZOF1 f 4.4183 0.8651 6.1284 2.7083
NODNZOF1 m 3.6033 0.8651 5.3134 1.8933
NODPWKF1 f 5.78 1.0595 7.8744 3.6856
NODPWKF1 m 5.0775 0.5298 6.1247 4.0303
NZOB6F1 f 5.0269 0.5298 6.0741 3.9797
NZOB6F1 m 4.41 1.0595 6.5044 2.3156
NZONODF1 f 5.2467 0.8651 6.9567 3.5366
NZONODF1 m 6.225 0.8651 7.935 4.515
PWKAF1 f 5.8625 1.0595 7.9569 3.7681
PWKAF1 m 5.01 1.0595 7.1044 2.9156
WSB129SF1 f 5.035 0.7492 6.5159 3.5541
WSB129SF1 m 4.115 1.0595 6.2094 2.0206
WSBB6F1 f 4.4975 1.0595 6.5919 2.4031
WSBB6F1 m 5.1333 0.8651 6.8434 3.4233
WSB/EiJ f 7.1283 0.8651 8.8384 5.4183
WSB/EiJ m 7.8425 1.0595 9.9369 5.7481
WSBNZOF1 f 3.7625 0.6117 4.9717 2.5533
WSBNZOF1 m 3.7717 0.8651 5.4817 2.0616


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129SAF1 both 5.4851 0.517 6.5071 4.4632
129SB6F1 both 4.2925 0.5471 5.374 3.211
129SNZOF1 both 4.5163 0.6488 5.7988 3.2337
129SPWKF1 both 5.455 0.6488 6.7375 4.1725
129SWSBF1 both 4.3642 0.5722 5.4953 3.2331
AB6F1 both 5.7172 0.5471 6.7987 4.6356
ACASTF1 both 5.8681 0.5298 6.9153 4.8209
ANZOF1 both 4.6276 0.5759 5.766 3.4892
APWKF1 both 8.095 0.6488 9.3775 6.8125
B6AF1/J both 4.5846 0.6839 5.9365 3.2327
B6NODF1 both 4.7325 0.7492 6.2134 3.2516
B6NZOF1 both 4.9917 0.6839 6.3436 3.6398
B6WSBF1 both 6.395 0.5298 7.4422 5.3478
CASTAF1 both 3.8962 0.7492 5.3772 2.4153
CAST/EiJ both 5.2625 0.6268 6.5015 4.0235
CASTNODF1 both 4.5592 0.6117 5.7683 3.35
CASTPWKF1 both 6.3738 0.4537 7.2706 5.4771
NODB6F1 both 5.5663 0.6488 6.8488 4.2837
NODCASTF1 both 3.6285 0.6268 4.8675 2.3895
NODNZOF1 both 4.0108 0.6117 5.22 2.8017
NODPWKF1 both 5.4287 0.5923 6.5995 4.258
NZOB6F1 both 4.7184 0.5923 5.8892 3.5477
NZONODF1 both 5.7358 0.6117 6.945 4.5267
PWKAF1 both 5.4362 0.7492 6.9172 3.9553
WSB129SF1 both 4.575 0.6488 5.8575 3.2925
WSBB6F1 both 4.8154 0.6839 6.1673 3.4635
WSB/EiJ both 7.4854 0.6839 8.8373 6.1335
WSBNZOF1 both 3.7671 0.5298 4.8143 2.7199




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA