MPD: Data set: Brown1

O'Leary TP, Gunn RK, Brown RE. What are we measuring when we test strain differences in anxiety in mice? Behav Genet. 2013 Jan;43(1):34-50. doi: 10.1007/s10519-012-9572-8. Epub 2013 Jan 4. PubMed 23288504

A set of definitions is available.

Procedures conducted:

• body weight
• elevated plus maze		Locomotor, exploratory, and anxiety-related behavior.
• elevated zero maze		Locomotor, exploratory, and anxiety-related behavior.
• light-dark box		Anxiety, avoidance behavior.
• open field test		Locomotor, exploratory, and anxiety-related behavior.

Brown1 downloads
• Download Brown1 project data set animal data, as uploaded
• Download Brown1 animal data matrix with factor-related expansion applied as necessary
• Download Brown1 strain means, SD, N, etc. one row per strain/sex/measure
• Brown1 supplementary data

Ontology terms mapped to Brown1 measures:

MP:0000436 abnormal head movements
MP:0001362 abnormal anxiety-related response
MP:0001392 abnormal locomotor behavior
MP:0001440 abnormal grooming behavior
MP:0001504 abnormal posture
MP:0001761 abnormal urination pattern
MP:0013189 abnormal exploration in a new environment
MP:0020147 abnormal defecation amount
VT:0001392 locomotor behavior trait
VT:0001440 grooming behavior trait
VT:0001505 body posture trait
VT:0003620 urine output
VT:0010461 excretion behavior trait
VT:0010462 defecation behavior trait
VT:0010471 exploratory behavior trait
VT:0010716 anxiety-related behavior trait
VT:0010732 head movement trait

Investigators	Richard E Brown Dalhousie University, Halifax, Nova Scotia CANADA Rhian K Gunn Dalhousie University, Halifax, Nova Scotia CANADA Heather M Schellinck Dalhousie University, Halifax, Nova Scotia CANADA Aimee A Wong Dalhousie University, Halifax, Nova Scotia CANADA Timothy P O'Leary Dalhousie University, Halifax, Nova Scotia CANADA
Contact	Richard E Brown rebrown@dal.ca Lab web site
Acknowledgements	Funding provided by Natural Sciences and Engineering Research Council of Canada (NSERC 7441) Generous funds from AstraZeneca R&D Boston were used to defray the cost of mice through the Mouse Phenome Project.
Project type	Phenotype strain survey data set
MPD identifiers	Brown1 MPD:94
Data changelog	No updates/corrections. Initial release date: 02/2008.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Brown1:1	Brown1	open field test	(none)	total locomotor activity, line crosses plus rearing, 5 min test, day 1 [n] activity_d1_OFT 9401	inbred	14	both	10wks	N=12

Brown1:2	Brown1	light-dark box	(none)	total activity, line crosses plus rearing, 5 min test [n] activity_LD 9402	inbred	14	both	10wks	N=13

Brown1:3	Brown1	elevated plus maze	(none)	total activity, line crosses plus rearing, 5 min test [n] activity_EPM 9403	inbred	14	both	10wks	N=11

Brown1:4	Brown1	elevated zero maze	(none)	total activity, line crosses plus rearing, 5 min test [n] activity_EZM 9404	inbred	13	both	10wks	N=9

Brown1:10	Brown1	open field test	(none)	fecal boli count, 5 min test, day 1 [n] defecation_d1_OFT 9410	inbred	14	both	10wks	N=13

Brown1:11	Brown1	open field test	(none)	freezing duration, day 1 [s] freeze_d1_OFT 9411	inbred	14	both	10wks	N=13

Brown1:12	Brown1	open field test	(none)	grooming duration, day 1 [s] groom_d1_OFT 9412	inbred	14	both	10wks	N=13

Brown1:13	Brown1	open field test	(none)	total stretch attends, 5 min test, day 1 [n] stretch_d1_OFT 9413	inbred	14	both	10wks	N=13

Brown1:14	Brown1	open field test	(none)	urine puddle count, 5 min test, day 1 [n] urination_d1_OFT 9414	inbred	14	both	10wks	N=13

Brown1:15	Brown1	light-dark box	(none)	dark zone duration [s] dark_dur_LD 9415	inbred	14	both	10wks	N=13

Brown1:16	Brown1	light-dark box	(none)	fecal boli count [n] defecation_LD 9416	inbred	14	both	10wks	N=13

Brown1:17	Brown1	light-dark box	(none)	grooming duration [s] groom_LD 9417	inbred	14	both	10wks	N=13

Brown1:18	Brown1	light-dark box	(none)	total stretch attends [n] stretch_LD 9418	inbred	14	both	10wks	N=13

Brown1:19	Brown1	light-dark box	(none)	urine puddle count [n] urination_LD 9419	inbred	14	both	10wks	N=13

Brown1:20	Brown1	elevated plus maze	(none)	open arms avoidance index [n] avoid_index_EPM 9420	inbred	14	both	10wks	N=12

Brown1:21	Brown1	elevated plus maze	(none)	closed arms duration [s] close_dur_EPM 9421	inbred	14	both	10wks	N=12

Brown1:22	Brown1	elevated plus maze	(none)	closed arms entries [n] close_ent_EPM 9422	inbred	14	both	10wks	N=12

Brown1:23	Brown1	elevated plus maze	(none)	closed arms, proportion of total time [ratio] close_prop_EPM 9423	inbred	14	both	10wks	N=12

Brown1:24	Brown1	elevated plus maze	(none)	fecal boli count [n] defecation_EPM 9424	inbred	14	both	10wks	N=13

Brown1:25	Brown1	elevated plus maze	(none)	grooming duration [s] groom_EPM 9425	inbred	14	both	10wks	N=13

Brown1:26	Brown1	elevated plus maze	(none)	total head-dips [n] headip_EPM 9426	inbred	14	both	10wks	N=13

Brown1:27	Brown1	elevated plus maze	(none)	total stretch attends [n] stretch_EPM 9427	inbred	14	both	10wks	N=13

Brown1:28	Brown1	elevated plus maze	(none)	urine puddle count [n] urination_EPM 9428	inbred	14	both	10wks	N=13

Brown1:29	Brown1	elevated zero maze	(none)	closed zone duration [s] close_dur_EZM 9429	inbred	13	both	10wks	N=9

Brown1:30	Brown1	elevated zero maze	(none)	closed zone entries [n] close_ent_EZM 9430	inbred	13	both	10wks	N=9

Brown1:31	Brown1	elevated zero maze	(none)	closed zone, proportion of total time [ratio] close_prop_EZM 9431	inbred	13	both	10wks	N=9

Brown1:32	Brown1	elevated zero maze	(none)	fecal boli count [n] defecation_EZM 9432	inbred	13	both	10wks	N=9

Brown1:33	Brown1	elevated zero maze	(none)	grooming duration [s] groom_EZM 9433	inbred	13	both	10wks	N=9

Brown1:34	Brown1	elevated zero maze	(none)	total head-dips [n] headip_EZM 9434	inbred	13	both	10wks	N=9

Brown1:35	Brown1	elevated zero maze	(none)	total stretch attends [n] stretch_EZM 9435	inbred	13	both	10wks	N=9

Brown1:36	Brown1	elevated zero maze	(none)	urine puddle count [n] urination_EZM 9436	inbred	13	both	10wks	N=9

Brown1:50	Brown1	open field test	(none)	total time in center square, 5 min test, day 1 [s] center_dur_d1_OFT 9450	inbred	14	both	10wks	N=13

Brown1:51	Brown1	open field test	(none)	total center square entries, 5 min test, day 1 [n] center_ent_d1_OFT 9451	inbred	14	both	10wks	N=13

Brown1:52	Brown1	light-dark box	(none)	light zone duration [s] light_dur_LD 9452	inbred	14	both	10wks	N=13

Brown1:53	Brown1	light-dark box	(none)	light zone, proportion of total time [ratio] light_prop_LD 9453	inbred	14	both	10wks	N=13

Brown1:54	Brown1	light-dark box	(none)	transitions between light and dark zones [n] trans_LD 9454	inbred	14	both	10wks	N=13

Brown1:55	Brown1	elevated plus maze	(none)	open arms duration [s] open_dur_EPM 9455	inbred	14	both	10wks	N=12

Brown1:56	Brown1	elevated plus maze	(none)	total open arms entries [n] open_ent_EPM 9456	inbred	14	both	10wks	N=12

Brown1:57	Brown1	elevated plus maze	(none)	open arms, percent of total entries [%] open_ent_prop_EPM 9457	inbred	14	both	10wks	N=12

Brown1:58	Brown1	elevated plus maze	(none)	open arms, proportion of total time [ratio] open_prop_EPM 9458	inbred	14	both	10wks	N=12

Brown1:59	Brown1	elevated zero maze	(none)	open zone duration [s] open_dur_EZM 9459	inbred	13	both	10wks	N=9

Brown1:60	Brown1	elevated zero maze	(none)	open zone entries [n] open_ent_EZM 9460	inbred	13	both	10wks	N=9

Brown1:61	Brown1	elevated zero maze	(none)	open zone, proportion of total time [ratio] open_prop_EZM 9461	inbred	13	both	10wks	N=9

Brown1:70	Brown1	body weight	(none)	body weight before test (local parameter) [g] bw_OFT 9470	inbred	14	both	10wks	N=13

Brown1: Anxiety, exploratory behavior, and motor activity in 14 inbred strains of mice (2004)

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