Studies involving Collaborative Cross 8 founders

List CC8 strains


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Data set Procedure What's in this data set Panel Sex Age (weeks) Year
Benavides1 genotype assessment Gpr84 allele assessment. PCR, sequencing. None None inbred w/CC8  (58) both 6wks 2013
CGDpheno3 body weight Body weight None BW CC diallel w/par  (62) both 8-16wks 2012
CGDpheno3 complete blood count Hematology. cell counts, white cells, lymphocytes, neutrophils, monocytes, basophils, eosinophils, large unstained cells, red cell parameters, hemoglobin, hematocrit, reticulocytes, platelets BASO, CBC, RBC, WBC, CHCM, EOS, HCT, HGB, LUC, LYM, MCH, MCHC, MONO, MPV, NEUT, PLT, RET, RETIC CC diallel w/par  (62) both 8-16wks 2012
CGDpheno3 DXA Body mass, fat mass, lean mass, bone mineral density and content, bone area. None BMD CC diallel w/par  (62) both 8-16wks 2012
CGDpheno3 ECG Wave amplitudes and intervals. Conscious. None ECG, EKG CC diallel w/par  (62) both 8-16wks 2012
CGDpheno3 lipid profile Cholesterol, HDL, triglycerides. 4h fast, plasma. None CHOL, TG CC diallel w/par  (62) both 8-16wks 2012
CGDpheno3 metabolic panel Glucose (plasma). 4h fast. None GLU CC diallel w/par  (62) both 8-16wks 2012
CGDpheno3 tail cuff Heart rate and blood pressure. Conscious mice. None BP, HR CC diallel w/par  (62) both 8-16wks 2012
Chesler2 behavior observation Wildness scoring. capture and hold None CC diallel w/par  (62) both 7-15wks 2011
Chesler2 body size and weight Body weight, body length, tail length. None BW CC diallel w/par  (62) both 7-15wks 2011
Chesler2 colony observation Reproduction, fecundity. Litter size, parental age, time from mate to first litter None CC diallel w/par  (62) both 7-15wks 2011
Chesler2 complete blood count Hematology. cell counts, white cells, lymphocytes, monocytes, granulocytes, eosinophils, red cell parameters, hemoglobin, hematocrit, platelets CBC, RBC, WBC, CHCM, EOS, HCT, HGB, LYM, MCH, MCHC, MONO, MPV, PLT CC diallel w/par  (62) both 7-15wks 2011
Chesler2 fat pad weights Gonadal fat pad weight. None None CC diallel w/par  (62) both 7-15wks 2011
Chesler2 light-dark box Anxiety, avoidance behavior. 10 min test. None None CC diallel w/par  (62) both 7-15wks 2011
Chesler2 metabolic panel Clinical blood chemistry. 16h fast. glucose, urea nitrogen, creatinine, sodium, potassium, chloride, calcium, carbon dioxide, anion gap concentration CO2, CREA, GLU, chem CC diallel w/par  (62) both 7-15wks 2011
Chesler2 monitoring system Sleep patterns. Dark period, total, peak activity. Baseline and after sleep deprivation. None None CC diallel w/par  (62) both 7-15wks 2011
Chesler2 nociception assay Hot plate and pressure on tail. None HP CC diallel w/par  (62) both 7-15wks 2011
Chesler2 open field test Locomotor activity, exploratory, anxiety-related behavior. 10 min test. None OFT CC diallel w/par  (62) both 7-15wks 2011
Chesler2 organ weights Heart, kidney weights. None None CC diallel w/par  (62) both 7-15wks 2011
Chesler3 behavior observation Wildness scoring. capture and hold None CC pre w/par  (367) both 7-15wks 2011
Chesler3 body size and weight Body weight, tail length. None BW CC pre w/par  (367) both 7-15wks 2011
Chesler3 bone dimensions Femur. None None CC pre w/par  (367) both 7-15wks 2011
Chesler3 colony observation Reproduction, fecundity. Litter size, parental age, time from mate to first litter None CC pre w/par  (367) both 7-15wks 2011
Chesler3 complete blood count Hematology. Cell counts, white cells, lymphocytes, monocytes, granulocytes, eosinophils, red cell parameters, hemoglobin, hematocrit, platelets CBC, RBC, WBC, CHCM, EOS, HCT, HGB, LYM, MCH, MCHC, MONO, MPV, PLT CC pre w/par  (367) both 7-15wks 2011
Chesler3 fat pad weights Gonadal fat pad weights. None None CC pre w/par  (367) both 7-15wks 2011
Chesler3 light-dark box Anxiety, avoidance behavior. 10 min test. None None CC pre w/par  (367) both 7-15wks 2011
Chesler3 metabolic panel Clinical blood chemistry. 16h fast. glucose, blood nitrogen, creatinine, sodium, potassium, chloride, calcium, carbon dioxide, anion gap concentration CO2, CREA, GLU, chem CC pre w/par  (367) both 7-15wks 2011
Chesler3 monitoring system Sleep patterns. Dark period, total, peak activity. Baseline and after sleep deprivation. None None CC pre w/par  (367) both 7-15wks 2011
Chesler3 nociception assay Hot plate and pressure on tail. None HP CC pre w/par  (367) both 7-15wks 2011
Chesler3 open field test Locomotor activity, exploratory, anxiety-related behavior. 10 min test. None OFT CC pre w/par  (367) both 7-15wks 2011
Chesler3 organ dimensions Kidney length and volume. None None CC pre w/par  (367) both 7-15wks 2011
Chesler3 organ weights Heart, brain, kidney, spleen, gonadal fat pads, testicle weights. None None CC pre w/par  (367) both 7-15wks 2011
Chesler4 body weight Body weight None BW DO population w/par  (9) both 12-16wks 2013
Chesler4 light-dark box Anxiety, avoidance behavior. 20 min test. None None DO population w/par  (9) both 12-16wks 2013
Chesler4 nociception assay Hot plate. None HP DO population w/par  (9) both 12-16wks 2013
Chesler4 open field test Locomotor activity, exploratory, anxiety-related behavior. 20 min test. None OFT DO population w/par  (9) both 12-16wks 2013
Chesler4 tail suspension test Frequency climbing, time immobile, latency immobile. 5 min test. struggle time, hopelessness, depression TST DO population w/par  (9) both 12-16wks 2013
Chesler4 visual cliff Anxiety, avoidance behavior. 20 min test. None None DO population w/par  (9) both 12-16wks 2013
Collins1 complete blood count Hematology. cell counts, white cells, lymphocytes, neutrophils, monocytes, eosinophis, basophils, red cell parameters, hemoglobin, platelets BASO, CBC, RBC, WBC, CHCM, HGB, LYM, MCH, MCHC, MONO, MPV, NEUT, PLT CC pre w/par  (139) m 10-14wks 2012
Crowley1 behavior observation
with haloperidol
Observed involuntary repetitive movement. Baseline vs. during and after haloperidol 60d implant (several timepoints). tongue protrusion, overt or subtle chewing movement, jaw tremor None inbred w/CC8  (27) m 9-28wks 2012
Crowley1 body weight
with haloperidol
Baseline vs. after haloperidol 60d implant. None BW inbred w/CC8  (27) m 9-28wks 2012
Crowley1 drug and metabolite quantification
with haloperidol
Haloperidol concentration (plasma). Baseline vs. during and after haloperidol 60d implant (several timepoints). None None inbred w/CC8  (27) m 9-28wks 2012
Crowley1 inclined screen test
with haloperidol
Baseline vs. during and after haloperidol 60d implant (several timepoints). extrapyramidal side effects, EPS None inbred w/CC8  (27) m 9-28wks 2012
Crowley1 open field test
with haloperidol
Locomotor activity, exploratory behavior, involuntary movement. Baseline vs. haloperidol 60d implant (several timepoints). 60 min test. None OFT inbred w/CC8  (27) m 9-28wks 2012
DiPetrillo2 urinalysis Microalbumin, creatinine, ratio. kidney Alb, CREA, MA CC pre w/par  (163) m 10wks 2012
Ferris1 body weight
with influenza A (H1N1) virus
Body weight None BW, flu CC pre w/par  (163) f 8-16wks 2012
Ferris1 health assessment
with influenza A (H1N1) virus
Clinical health assessment score and strain susceptibility index 4 days after infection with influenza A (H1N1) virus. None flu CC pre w/par  (163) f 8-16wks 2012
Ferris1 histopathology
with influenza A (H1N1) virus
Lungs and airway 4 days after infection with influenza A (H1N1) virus. alveolar and airway Inflammation, neutrophils, virus-induced damage, pulmonary edema NEUT, flu CC pre w/par  (163) f 8-16wks 2012
Ferris1 in vitro assay
with influenza A (H1N1) virus
Viral replication log titer 4 days after infection with influenza A (H1N1) virus. In vitro. None flu CC pre w/par  (163) f 8-16wks 2012
Mathes1 body weight
with exercise
Baseline vs. after exercise (access to running wheel). None BW CC pre w/par  (184) m 10-12wks 2011
Mathes1 intake monitoring
with exercise
Caloric intake. Baseline vs. after exercise (access to running wheel). Metabolism, food intake. None None CC pre w/par  (184) m 10-12wks 2011
Mathes1 monitoring system
with exercise
Respiratory exchange ratio. Baseline (before access to running wheel). None RER CC pre w/par  (184) m 10-12wks 2011
Mathes1 MRI
with exercise
Body composition (percent fat). Baseline vs. after exercise (access to running wheel). None None CC pre w/par  (184) m 10-12wks 2011
Mathes1 running wheel monitoring
with exercise
Distance, speed at days 1, 6, and 12. exercise, endurance, conditioning None CC pre w/par  (184) m 10-12wks 2011
Morgan1 body weight
with high-fat diet and olanzapine
Body weight and growth curve from age 8wks to 18wks weighed every 2wks. Olanzapine vs. control (both groups high-fat diet). None BW inbred w/CC8  (9) f 7-12wks 2014
Schughart3 body weight
with influenza A (H3N2) virus
Influenza A (H3N2) virus (several doses) vs. baseline. Several timepoints. None BW, flu inbred w/CC8  (8) both 7-13wks 2013
Schughart3 health assessment
with influenza A (H3N2) virus
Survival rate, susceptibility, influenza A (H3N2) virus (several doses). None flu inbred w/CC8  (8) both 7-13wks 2013
Schughart4 body weight
with influenza A (H3N2) virus
Influenza A (H3N2) virus vs. controls. Several timepoints. None BW, flu inbred w/CC8  (8) f 8-12wks 2016
Schughart4 complete blood count
with influenza A (H3N2) virus
White blood cell count and differentials. Influenza A (H3N2) virus vs. controls. None WBC, flu inbred w/CC8  (8) f 8-12wks 2016
Schughart4 in vitro assay
with influenza A (H3N2) virus
Viral load in lungs after infection with influenza A (H3N2) virus. None flu inbred w/CC8  (8) f 8-12wks 2016
Schughart5 body weight
with influenza A (H3N2) virus
Influenza A (H3N2) virus vs. controls. Several timepoints. None BW, flu inbred w/CC8  (8) f 8-12wks 2016
Schughart5 organ weights
with influenza A (H3N2) virus
Lung weight. Animals infected with influenza A (H3N2) virus vs. controls. None flu inbred w/CC8  (8) f 8-12wks 2016
UNC-MMUGA2 genotyping SNP profiling, 76,000+ genomic locations, 1-19,X,MT None SNPs CC w/par  (77) both 2017