Crowley1: Drug study: Haloperidol-induced vacuous chewing movements, extrapyramidal side effects, and spontaneous locomotor activity in males of 27 inbred mouse strains (2012)
Crowley JJ, Adkins DE, Pratt AL, Quackenbush CR, van den Oord EJ, Moy SS, Wilhelmsen KC, Cooper TB, Bogue MA, McLeod HL, Sullivan PF. Antipsychotic-induced vacuous chewing movements and extrapyramidal side effects are highly heritable in mice.
Pharmacogenomics J. 2012 Apr;12(2):147-55. doi: 10.1038/tpj.2010.82. Epub 2010 Nov 16.
Mice were implanted with 60-day release
haloperidol
pellets to produce a steady-state plasma concentration at levels therapeutic for humans (chronic exposure).
Mice were subjected to a battery of behavioral tests at specified times post-implant, including times
post-exposure (>day 60) to study the long-term effects of haloperidol. There was one cohort;
baseline measurements were done prior to implantation, and plasma haloperidol
levels were determined at specified times post-implant.
Procedures conducted:
Procedures conducted:
| Baseline vs. after haloperidol 60d implant. | ||
| Haloperidol concentration (plasma). Baseline vs. during and after haloperidol 60d implant (several timepoints). | ||
| Baseline vs. during and after haloperidol 60d implant (several timepoints). | ||
| Locomotor activity, exploratory behavior, involuntary movement. Baseline vs. haloperidol 60d implant (several timepoints). 60 min test. | ||
| Observed involuntary repetitive movement. Baseline vs. during and after haloperidol 60d implant (several timepoints). |
Crowley1 downloads
• Download Crowley1 project data set animal data, as uploaded
• Download Crowley1 animal data matrix with factor-related expansion applied as necessary
• Download Crowley1 strain means, SD, N, etc. one row per strain/sex/measure
• Crowley1 supplementary data
• Download Crowley1 project data set animal data, as uploaded
• Download Crowley1 animal data matrix with factor-related expansion applied as necessary
• Download Crowley1 strain means, SD, N, etc. one row per strain/sex/measure
• Crowley1 supplementary data
Ontology terms mapped to Crowley1 measures:
| Investigators |
James J Crowley University of North Carolina, Chapel Hill, NC Howard L McLeod University of North Carolina, Chapel Hill, NC Patrick F Sullivan University of North Carolina, Chapel Hill, NC |
| Participants | Adkins DE, Pratt AL, Quackenbush CR, van den Oord EJ, Moy SS, Wilhelmsen KC, Cooper TB |
| Contact | James J Crowley crowley@unc.edu
|
| Acknowledgements | Funding provided by NIH GM63340, MH90338, HD03110, MH080403, MH077139, MH074027.
Mice provided through a collaboration with the Mouse Phenome Project, The Jackson Laboratory. |
| Phenotype strain survey data set | |
| MPD identifiers | Crowley1 MPD:394 |
| No updates/corrections. Initial release date: 11/2011. | |
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Click above to copy-paste the entire citation for this MPD web page. |
