Schughart4: Susceptibility to influenza A (H3N2) viral infection: body weight, viral loads and leukocyte profiles in females of the 8 inbred founder strains of the Collaborative Cross (2016)

Leist SR, Pilzner C, van den Brand JM, Dengler L, Geffers R, Kuiken T, Balling R, Kollmus H, Schughart K. Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice. BMC Genomics. 2016 Feb 27;17:143. doi: 10.1186/s12864-016-2483-y.   PubMed 26921172     FullText

Schughart4 downloads
• Download Schughart4 project data set     animal data, as uploaded
• Download Schughart4 animal data matrix     with factor-related expansion applied as necessary
• Download Schughart4 strain means, SD, N, etc.     one row per strain/sex/measure
Investigators Sarah R Leist       Helmholtz Center for Infection Research,  Braunschweig GERMANY
Heike Kollmus       Helmholtz Center for Infection Research,  Braunschweig GERMANY
Klaus Schughart       Helmholtz Center for Infection Research,  Braunschweig GERMANY
ContactKlaus Schughart     Lab web site
Part of a series: • study 1   see Schughart3
• study 2   (this project) Schughart4
• study 3   see Schughart5
Project type Phenotype strain survey data set
MPD identifiersSchughart4     MPD:587
Data changelog No updates/corrections.       Initial release date: 01/2017.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Mice infected with influenza A H3N2 virus (one dose) were analyzed for daily weight loss for up to 30 days. The mouse-adapted virus strain influenza A/HK/01/68 was used. Viral loads and leukocyte profiles are also available. Overall survival and mortality rates are available from females and males in Schughart3, and lung weights are available from females in Schughart5.

Procedures conducted:
• body weight  Influenza A (H3N2) virus vs. controls. Several timepoints.
• complete blood count  White blood cell count and differentials. Influenza A (H3N2) virus vs. controls.
• in vitro assay  Viral load in lungs after infection with influenza A (H3N2) virus.

Mice: inbred w/CC8   8 strains   ♀   age 8-12wks   2 experimental groups