Ferris1: Host response to Influenza A (H1N1) in 8 inbred founder strains and 150+ emerging lines (pre-CC) of the Collaborative Cross (2012)

Ferris MT, Aylor DL, Bottomly D, Whitmore AC, Aicher LD, Bell TA, Bradel-Tretheway B, Bryan JT, Buus RJ, Gralinski LE, Haagmans BL, McMillan L, Miller DR, Rosenzweig E, Valdar W, Wang J, Churchill GA, Threadgill DW, McWeeney SK, Katze MG, Pardo-Manuel de Modeling host genetic regulation of influenza pathogenesis in the collaborative cross. PLoS Pathog. 2013 Feb;9(2):e1003196. doi: 10.1371/journal.ppat.1003196. Epub 2013 Feb 28.   PubMed 23468633     FullText

Ferris1 downloads
• Download Ferris1 project data set     animal data, as uploaded
• Download Ferris1 animal data matrix     with factor-related expansion applied as necessary
• Download Ferris1 strain means, SD, N, etc.     one row per strain/sex/measure
• Ferris1 supplementary data
Investigators Martin T Ferris       University of North Carolina,  Chapel Hill, NC
Daniel Bottomly       Oregon Health & Science University,  Portland, OR
Shannon K McWeeney       Oregon Health & Science University,  Portland, OR
Mark T Heise       University of North Carolina,  Chapel Hill, NC
Participants Aicher LD, Rosenzweig E, Whitmore A, Aylor DL, Haagmans BL, Gralinski LE, Bradel-Tretheway BG, Bryan JT, Threadgill DW, de Villena FP, Baric RS, Katze MG
ContactMartin T Ferris     mtferris@email.unc.edu     Lab web site
AcknowledgementsFunding provided by AI081680, AI100625, AI084322, CA134240, CA069533, GM076468, RR024140; VIRGO consortium (BSIK 03012)
Project type Phenotype strain survey data set
MPD identifiersFerris1     MPD:476
Data changelog 1 update/correction.       Initial release date: 06/2013.
Formatted citation
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An assessment of emerging CC lines. Generations range from G2:F5 to G2:F11. Data for the 8 founder strains are also present.

Procedures conducted:
• body weight 
• health assessment  Clinical health assessment score and strain susceptibility index 4 days after infection with influenza A (H1N1) virus.
• in vitro assay  Viral replication log titer 4 days after infection with influenza A (H1N1) virus. In vitro.
• histopathology  Lungs and airway 4 days after infection with influenza A (H1N1) virus.

Mice: CC pre w/par   163 strains   ♀   age 8-16wks   1 experimental group