Schughart5: Susceptibility to influenza A (H3N2) viral infection: body weight and lung weight in females of the 8 inbred founder strains of the Collaborative Cross (2016)

Leist SR, Pilzner C, van den Brand JM, Dengler L, Geffers R, Kuiken T, Balling R, Kollmus H, Schughart K. Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice. BMC Genomics. 2016 Feb 27;17:143. doi: 10.1186/s12864-016-2483-y.   PubMed 26921172     FullText

Schughart5 downloads
• Download Schughart5 project data set     animal data, as uploaded
• Download Schughart5 animal data matrix     with factor-related expansion applied as necessary
• Download Schughart5 strain means, SD, N, etc.     one row per strain/sex/measure
Investigators Sarah R Leist       Helmholtz Center for Infection Research,  Braunschweig GERMANY
Heike Kollmus       Helmholtz Center for Infection Research,  Braunschweig GERMANY
Klaus Schughart       Helmholtz Center for Infection Research,  Braunschweig GERMANY
ContactKlaus Schughart     Lab web site
Part of a series: • study 1   see Schughart3
• study 2   see Schughart4
• study 3   (this project) Schughart5
Project type Phenotype strain survey data set
MPD identifiersSchughart5     MPD:588
Data changelog No updates/corrections.       Initial release date: 01/2017.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Mice infected with influenza A H3N2 virus (one dose) were analyzed for daily weight loss for up to 30 days. The mouse-adapted virus strain influenza A/HK/01/68 was used. Lung weights are also available. Overall survival and mortality rates are available from females and males in Schughart3, and viral loads and leukocyte profiles are available in Schughart4.

Procedures conducted:
• body weight  Influenza A (H3N2) virus vs. controls. Several timepoints.
• organ weights  Lung weight. Animals infected with influenza A (H3N2) virus vs. controls.

Mice: inbred w/CC8   8 strains   ♀   age 8-12wks   2 experimental groups