CGDpheno3: Multi-system survey of mouse physiology in 8 inbred founder strains and 54 F1 hybrids of the Collaborative Cross (2012)

Lenarcic AB, Svenson KL, Churchill GA, Valdar W. A general Bayesian approach to analyzing diallel crosses of inbred strains. Genetics. 2012 Feb;190(2):413-35.   PubMed 22345610     FullText

CGDpheno3 downloads
• Download CGDpheno3 project data set     one row per animal, one column per trait
• Download CGDpheno3 strain means, SD, N, etc.     one row per strain/sex/measure
Ontology terms mapped to CGDpheno3 measures:
    MA:0000009   adipose tissue
    MA:0000010   cardiovascular system
    MA:0000059   blood
    MA:0000072   heart
    MA:0001459   bone
    MA:0002501   plasma
    MP:0000180   abnormal circulating cholesterol level
    MP:0000184   abnormal circulating HDL cholesterol level
    MP:0000188   abnormal circulating glucose level
    MP:0000217   abnormal leukocyte cell number
    MP:0000226   abnormal mean corpuscular volume
    MP:0000230   abnormal systemic arterial blood pressure
    MP:0000717   abnormal lymphocyte cell number
    MP:0001259   abnormal body weight
    MP:0001586   abnormal erythrocyte cell number
    MP:0001588   abnormal hemoglobin
    MP:0001589   abnormal mean corpuscular hemoglobin
    MP:0001629   abnormal heart rate
    MP:0002089   abnormal postnatal growth/weight/body size
    MP:0002586   abnormal platelet volume
    MP:0002596   abnormal hematocrit
    MP:0002602   abnormal eosinophil cell number
    MP:0003795   abnormal bone structure
    MP:0003897   abnormal ST segment
    MP:0003898   abnormal QRS complex
    MP:0003899   abnormal QT interval
    MP:0003901   abnormal PR interval
    MP:0003956   abnormal body size
    MP:0003959   abnormal lean body mass
    MP:0005457   abnormal percent body fat/body weight
    MP:0005640   abnormal mean corpuscular hemoglobin concentration
    MP:0008849   abnormal hemoglobin concentration distribution width
    MP:0010066   abnormal red blood cell distribution width
    MP:0010119   abnormal bone mineral density
    MP:0010122   abnormal bone mineral content
    MP:0010504   abnormal RR interval
    MP:0010695   abnormal blood pressure regulation
    MP:0011898   abnormal platelet cell number
    MP:0011913   abnormal reticulocyte cell number
    MP:0011918   abnormal PQ interval
    MP:0011919   abnormal R wave
    MP:0011969   abnormal circulating triglyceride level
    MP:0012321   abnormal total tissue mass
    MP:0012360   abnormal large unstained cell number
    MP:0012397   abnormal nucleated erythrocyte cell number
    MP:0012440   abnormal neutrophil cell number
    MP:0012441   abnormal monocyte cell number
    MP:0012442   abnormal basophil cell number
    VT:0000180   blood cholesterol amount
    VT:0000183   blood pressure trait
    VT:0000184   blood HDL cholesterol amount
    VT:0000188   blood glucose amount
    VT:0000217   leukocyte quantity
    VT:0000222   neutrophil quantity
    VT:0000223   monocyte quantity
    VT:0000231   heart excitatory physiology trait
    VT:0000248   erythrocyte size trait
    VT:0000717   lymphocyte quantity
    VT:0001259   body mass
    VT:0001586   erythrocyte quantity
    VT:0001588   blood hemoglobin amount
    VT:0002447   erythrocyte morphology trait
    VT:0002602   eosinophil quantity
    VT:0002607   basophil quantity
    VT:0002644   blood triglyceride amount
    VT:0003135   reticulocyte quantity
    VT:0003179   platelet quantity
    VT:0004152   blood iron amount
    VT:0005007   bone mineral mass
    VT:0005452   adipose amount
    VT:0010003   bone morphology trait
    VT:0010457   platelet size trait
    VT:0010482   body fat mass
    VT:0010483   body lean mass
    VT:0100005   body size trait
    VT:2000009   heart pumping trait
Institutional authorship Center for Genome Dynamics (CGD)     Lab web site
Participants Svenson KL, Lenarcic AB, Churchill GA, Valdar W
ContactKaren L Svenson     Lab web site
AffiliationCenter for Genome Dynamics (CGD)
AcknowledgementsPartial support from the National Institutes of Health (NIH) Center of Excellence in Genome Sciences grants P50 MH090338 and P50 MH006582, from NIH grant GM076468, from The Jackson Laboratory, and from the University of North Carolina Lineberger Comprehensive Cancer Center.
Project type Phenotype strain survey data set
MPD identifiersCGDpheno3     MPD:439
Data changelog No updates/corrections.       Initial release date: 12/2012.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
An assessment of F1 hybrids bred from the 8 CC founder strains. Data for the founder strains are also present.

Summary of procedures that were conducted
• metabolic panel Glucose (plasma). 4h fast.
• lipid profile Cholesterol, HDL, triglycerides. 4h fast, plasma.
• complete blood count Hematology.
• tail cuff Heart rate and blood pressure. Conscious mice.
• ECG Wave amplitudes and intervals. Conscious.
• DXA Body mass, fat mass, lean mass, bone mineral density and content, bone area.
• body weight
Mice: CC diallel w/par   62 strains   ♀♂   age 8-16wks   1 cohort