CGDpheno3: Multi-system survey of mouse physiology in 8 inbred founder strains and 54 F1 hybrids of the Collaborative Cross (2012)

Lenarcic AB, Svenson KL, Churchill GA, Valdar W. A general Bayesian approach to analyzing diallel crosses of inbred strains. Genetics. 2012 Feb;190(2):413-35.   PubMed 22345610     FullText

CGDpheno3 downloads
• Download CGDpheno3 project data set     animal data, as uploaded
• Download CGDpheno3 animal data matrix     with factor-related expansion applied as necessary
• Download CGDpheno3 strain means, SD, N, etc.     one row per strain/sex/measure
Ontology terms mapped to CGDpheno3 measures:
  MA:0000009   adipose tissue
  MA:0000010   cardiovascular system
  MA:0000059   blood
  MA:0000072   heart
  MA:0001459   bone
  MA:0002501   plasma
  MP:0000180   abnormal circulating cholesterol level
  MP:0000184   abnormal circulating HDL cholesterol level
  MP:0000188   abnormal circulating glucose level
  MP:0000217   abnormal leukocyte cell number
  MP:0000226   abnormal mean corpuscular volume
  MP:0000230   abnormal systemic arterial blood pressure
  MP:0000717   abnormal lymphocyte cell number
  MP:0001259   abnormal body weight
  MP:0001586   abnormal erythrocyte cell number
  MP:0001588   abnormal hemoglobin
  MP:0001589   abnormal mean corpuscular hemoglobin
  MP:0001629   abnormal heart rate
  MP:0002089   abnormal postnatal growth/weight/body size
  MP:0002586   abnormal platelet volume
  MP:0002596   abnormal hematocrit
  MP:0002602   abnormal eosinophil cell number
  MP:0003795   abnormal bone structure
  MP:0003897   abnormal ST segment
  MP:0003898   abnormal QRS complex
  MP:0003899   abnormal QT interval
  MP:0003901   abnormal PR interval
  MP:0003956   abnormal body size
  MP:0003959   abnormal lean body mass
  MP:0005457   abnormal percent body fat/body weight
  MP:0005640   abnormal mean corpuscular hemoglobin concentration
  MP:0008849   abnormal hemoglobin concentration distribution width
  MP:0010066   abnormal red blood cell distribution width
  MP:0010119   abnormal bone mineral density
  MP:0010122   abnormal bone mineral content
  MP:0010504   abnormal RR interval
  MP:0010695   abnormal blood pressure regulation
  MP:0011898   abnormal platelet cell number
  MP:0011913   abnormal reticulocyte cell number
  MP:0011918   abnormal PQ interval
  MP:0011919   abnormal R wave
  MP:0011969   abnormal circulating triglyceride level
  MP:0012321   abnormal total tissue mass
  MP:0012360   abnormal large unstained cell number
  MP:0012397   abnormal nucleated erythrocyte cell number
  MP:0012440   abnormal neutrophil cell number
  MP:0012441   abnormal monocyte cell number
  MP:0012442   abnormal basophil cell number
  VT:0000180   blood cholesterol amount
  VT:0000183   blood pressure trait
  VT:0000184   blood HDL cholesterol amount
  VT:0000188   blood glucose amount
  VT:0000217   leukocyte quantity
  VT:0000222   neutrophil quantity
  VT:0000223   monocyte quantity
  VT:0000231   heart excitatory physiology trait
  VT:0000248   erythrocyte size trait
  VT:0000717   lymphocyte quantity
  VT:0001259   body mass
  VT:0001586   erythrocyte quantity
  VT:0001588   blood hemoglobin amount
  VT:0002447   erythrocyte morphology trait
  VT:0002602   eosinophil quantity
  VT:0002607   basophil quantity
  VT:0002644   blood triglyceride amount
  VT:0003135   reticulocyte quantity
  VT:0003179   platelet quantity
  VT:0004152   blood iron amount
  VT:0005007   bone mineral mass
  VT:0005452   adipose amount
  VT:0010003   bone morphology trait
  VT:0010457   platelet size trait
  VT:0010482   body fat mass
  VT:0010483   body lean mass
  VT:0100005   body size trait
  VT:2000009   heart pumping trait

Institutional authorship Center for Genome Dynamics (CGD)     Lab web site
Investigators Karen L Svenson       The Jackson Laboratory,  Bar Harbor, ME
Participants Svenson KL, Lenarcic AB, Churchill GA, Valdar W
ContactKaren L Svenson     Lab web site
AcknowledgementsPartial support from the National Institutes of Health (NIH) Center of Excellence in Genome Sciences grants P50 MH090338 and P50 MH006582, from NIH grant GM076468, from The Jackson Laboratory, and from the University of North Carolina Lineberger Comprehensive Cancer Center.
Project type Phenotype strain survey data set
MPD identifiersCGDpheno3     MPD:439
Data changelog No updates/corrections.       Initial release date: 12/2012.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
An assessment of F1 hybrids bred from the 8 CC founder strains. Data for the founder strains are also present.

Procedures conducted:
• metabolic panel  Glucose (plasma). 4h fast.
• lipid profile  Cholesterol, HDL, triglycerides. 4h fast, plasma.
• complete blood count  Hematology.
• tail cuff  Heart rate and blood pressure. Conscious mice.
• ECG  Wave amplitudes and intervals. Conscious.
• DXA  Body mass, fat mass, lean mass, bone mineral density and content, bone area.
• body weight 

Mice: CC diallel w/par   62 strains   ♀♂   age 8-16wks   1 experimental group