Mathes1: Energy balance traits in 8 inbred founder strains and 170+ emerging lines (pre-CC) of the Collaborative Cross (2011)

Mathes WF, Aylor DL, Miller DR, Churchill GA, Chesler EJ, de Villena FP, Threadgill DW, Pomp D. Architecture of energy balance traits in emerging lines of the Collaborative Cross. Am J Physiol Endocrinol Metab. 2011 Jun;300(6):E1124-34. Epub 2011 Mar 22.   PubMed 21427413     FullText


         
An assessment of emerging CC lines. Generations range from G2:F5 to G2:F12. Data for the 8 founder strains are also present.

Procedures conducted:
• body weight  Baseline vs. after exercise (access to running wheel).
• MRI  Body composition (percent fat). Baseline vs. after exercise (access to running wheel).
• intake monitoring  Caloric intake. Baseline vs. after exercise (access to running wheel). Metabolism, food intake.
• monitoring system  Respiratory exchange ratio. Baseline (before access to running wheel).
• running wheel monitoring  Distance, speed at days 1, 6, and 12.

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Investigators Wendy F Mathes       University of North Carolina,  Chapel Hill, NC
Participants Aylor DL, Miller DR, Churchill GA, Chesler EJ, de Villena FP, Threadgill DW, Pomp D
ContactWendy F Mathes     wfmathes@med.unc.edu
AcknowledgementsFunding provided by NIH DK076050, DK056350, CA105417, CA134240, GM076468, GM090667, MH090338, MH076694, HD01441; the Ellison Medical Foundation AG-IA-0202-05; Lineberger Comprehensive Cancer Center, University Cancer Research Fund (North Carolina), US Department of Energy
Project type Phenotype strain survey data set
MPD identifiersMathes1     MPD:452
Data changelog 2 updates/corrections.       Initial release date: 02/2013.
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Mice: CC pre w/par   184 strains   ♂   age 10-12wks   1 experimental group

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Treatment
Phenotype Measure / Variable (click to view)
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No. of Strains
Sex
Age
    Mathes1 body weight exercise body weight   [g]  bw   45201     before exercise    after exercise    difference CC pre w/par 184 m 10-12wks N=1
    Mathes1 MRI exercise percent fat, whole body with head   [%]  pct_fat   45204     before exercise    after exercise    difference CC pre w/par 184 m 10-12wks N=1
    Mathes1 intake monitoring exercise caloric intake   [kcal/d]  calories   45207     before exercise    during exercise CC pre w/par 183 m 10-12wks N=1
    Mathes1 monitoring system (none) nocturnal respiratory exchange ratio (RER) prior to wheel running (VCO2:VO2)   [ratio]  RER_pre   45209 CC pre w/par 138 m 10-12wks N=1
    Mathes1 running wheel monitoring (none) distance traveled on wheel   [m/d]  run_dist   45210     day 1    day 6    day 12 CC pre w/par 184 m 10-12wks N=1
    Mathes1 running wheel monitoring (none) speed on wheel   [m/min]  run_speed   45213     day 1    day 6    day 12 CC pre w/par 184 m 10-12wks N=1
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