Chesler4: Behavioral and nociception traits in a Diversity Outbred (DO) mouse population and 8 founder inbred strains (2013)

Logan RW, Robledo RF, Recla JM, Philip VM, Bubier JA, Jay JJ, Harwood C, Wilcox T, Gatti DM, Bult CJ, Churchill GA, Chesler EJ. High-precision genetic mapping of behavioral traits in the diversity outbred mouse population. Genes Brain Behav. 2013 Jun;12(4):424-37. doi: 10.1111/gbb.12029. Epub 2013 Mar 20.   PubMed 23433259  

Recla JM, Robledo RF, Gatti DM, Bult CJ, Churchill GA, Chesler EJ. Precise genetic mapping and integrative bioinformatics in Diversity Outbred mice reveals Hydin as a novel pain gene. Mamm Genome. 2014 Jun;25(5-6):211-22. doi: 10.1007/s00335-014-9508-0. Epub 2014 Apr 5.   PubMed 24700285     FullText


         
Chesler4 downloads
• Download Chesler4 project data set     animal data, as uploaded
• Download Chesler4 animal data matrix     with factor-related expansion applied as necessary
• Download Chesler4 strain means, SD, N, etc.     one row per strain/sex/measure
• Chesler4 supplementary data
Investigators Ryan W Logan       The Jackson Laboratory,  Bar Harbor, ME
Raymond F Robledo       The Jackson Laboratory,  Bar Harbor, ME
Jill M Recla       The Jackson Laboratory,  Bar Harbor, ME
Elissa J Chesler       The Jackson Laboratory,  Bar Harbor, ME
Participants Philip VM, Bubier JA, Jay JJ, Harwood C, Wilcox T, Gatti DM, Bult CJ, Churchill GA
ContactElissa J Chesler     elissa.chesler@jax.org     Lab web site
AcknowledgementsFunding provided by NIH GM076468, AG038070
Project type Phenotype strain survey data set
MPD identifiersChesler4     MPD:470
Data changelog No updates/corrections.       Initial release date: 06/2013.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
• Correlations matrix for all measurements . See also QTL project Recla1 which includes a genotype component.

Procedures conducted:
• open field test  Locomotor activity, exploratory, anxiety-related behavior. 20 min test.
• visual cliff  Anxiety, avoidance behavior. 20 min test.
• light-dark box  Anxiety, avoidance behavior. 20 min test.
• tail suspension test  Frequency climbing, time immobile, latency immobile. 5 min test.
• nociception assay  Hot plate.
• body weight 

Mice: DO population w/par   9 strains   ♀♂   age 12-16wks   1 experimental group