Morgan1: Drug study: Effects of olanzapine on body weight in 9 inbred strains of mice (2014)

Morgan AP, Crowley JJ, Nonneman RJ, Quackenbush CR, Miller CN, Ryan AK, Bogue MA, Paredes SH, Yourstone S, Carroll IM, Kawula TH, Bower MA, Sartor RB, Sullivan PF. The antipsychotic olanzapine interacts with the gut microbiome to cause weight gain in mouse. PLoS One. 2014 Dec 15;9(12):e115225. doi: 10.1371/journal.pone.0115225. eCollection 2014.   PubMed 25506936     FullText


       
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Participants Andrew P Morgan       University of North Carolina Chapel Hill, NC
James J Crowley       University of North Carolina Chapel Hill, NC
Patrick F Sullivan       University of North Carolina Chapel Hill, NC
With: Nonneman RJ, Quackenbush CR, Miller CN, Ryan AK, Bogue MA, Paredes SH, Yourstone S, Carroll IM, Kawula TH, Bower MA, Sartor RB
ContactAndrew P Morgan     andrew_morgan@med.unc.edu     Lab web site
AcknowledgementsFunding provided by NIH MH097173, MH094406, DK034987, DK056350, OD010995, GM067553, GM008719; Howard Hughes Medical Institute.
Project type Phenotype strain survey data set
MPD identifiersMorgan1     MPD:526
Data changelog No updates/corrections.       Initial release date: 02/2015.
Formatted citation
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Mice were randomized to receive a high-fat diet +/- olanzapine from 8-18 wks. Strain set includes all of the Collaborative Cross 8 founder strains.

Summary of procedures that were conducted
• body weight Body weight and growth curve from age 8wks to 18wks weighed every 2wks. Olanzapine vs. control (both groups high-fat diet).
Mice: inbred   9 strains   ♀   age 7-12wks   2 cohorts

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Morgan1 52601 body weight (none) starting body weight   [g]     control group    treatment group inbred w/CC8 9 f 8wks N=4
    Morgan1 52613 body weight high-fat diet percent change in body weight, age 10wks vs. 8wks   [%]     age 10wks:    control    treated inbred w/CC8 9 f 10wks N=4
    Morgan1 52615 body weight high-fat diet percent change in body weight, age 12wks vs. 8wks   [%]     age 12wks:    control    treated inbred w/CC8 9 f N=4
    Morgan1 52617 body weight high-fat diet percent change in body weight, age 14wks vs. 8wks   [%]     age 14wks:    control    treated inbred w/CC8 9 f N=4
    Morgan1 52619 body weight high-fat diet percent change in body weight, age 16wks vs. 8wks   [%]     age 16wks:    control    treated inbred w/CC8 9 f N=4
    Morgan1 52621 body weight high-fat diet percent change in body weight, age 18wks vs. 8wks   [%]     age 18wks:    control    treated inbred w/CC7 8 f N=4
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