|
ALT_Rx50 alanine transaminase (serum ALT)
, dose: 50 mg/kg
39602
|
Female |
|
|
|
|
|
Male |
5 |
4 |
5 |
5 |
4 |
|
liver_necrosis liver necrosis score
39603
|
Female |
|
|
|
|
|
Male |
5 |
5 |
5 |
4 |
5 |
|
pct_nitrotyrosine percent nitrotyrosine staining (marker of hepatocyte injury)
39604
|
Female |
|
|
|
|
|
Male |
5 |
4 |
5 |
4 |
5 |
|
GSH_ctr reduced glutathione (GSH)
, control
39605
|
Female |
|
|
|
|
|
Male |
3 |
3 |
3 |
3 |
3 |
|
GSH_pct_ctr percent reduced glutathione
, control
39606
|
Female |
|
|
|
|
|
Male |
3 |
3 |
3 |
3 |
3 |
|
GSH_total_ctr total glutathione
, control
39607
|
Female |
|
|
|
|
|
Male |
3 |
3 |
3 |
3 |
3 |
|
APAP50_0 serum acetaminophen (APAP), 50 mg/mL dose acetaminophen
, baseline
39609
|
Female |
|
|
|
|
|
Male |
5 |
4 |
5 |
5 |
5 |
|
APAP50_0.5 serum acetaminophen (APAP), 50 mg/mL dose acetaminophen
, 0.5h
39610
|
Female |
|
|
|
|
|
Male |
5 |
4 |
5 |
5 |
5 |
|
APAP50_1 serum acetaminophen (APAP), 50 mg/mL dose acetaminophen
, 1h
39612
|
Female |
|
|
|
|
|
Male |
5 |
4 |
5 |
5 |
5 |
|
APAP50_2 serum acetaminophen (APAP), 50 mg/mL dose acetaminophen
, 2h
39613
|
Female |
|
|
|
|
|
Male |
5 |
4 |
5 |
5 |
5 |
|
APAP50_3 serum acetaminophen (APAP), 50 mg/mL dose acetaminophen
, 3h
39614
|
Female |
|
|
|
|
|
Male |
5 |
3 |
5 |
5 |
4 |
|
APAP50_6 serum acetaminophen (APAP), 50 mg/mL dose acetaminophen
, 6h
39615
|
Female |
|
|
|
|
|
Male |
5 |
4 |
5 |
5 |
4 |
|
APAP_Sulf_50_0 serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen
, baseline
39616
|
Female |
|
|
|
|
|
Male |
5 |
4 |
5 |
5 |
5 |
|
APAP_Sulf_50_0.5 serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen
, 0.5h
39617
|
Female |
|
|
|
|
|
Male |
5 |
4 |
4 |
5 |
5 |
|
APAP_Sulf_50_1 serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen
, 1h
39618
|
Female |
|
|
|
|
|
Male |
5 |
4 |
5 |
5 |
5 |
|
APAP_Sulf_50_2 serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen
, 2h
39619
|
Female |
|
|
|
|
|
Male |
5 |
4 |
5 |
5 |
5 |
|
APAP_Sulf_50_3 serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen
, 3h
39620
|
Female |
|
|
|
|
|
Male |
5 |
3 |
5 |
5 |
4 |
|
APAP_Sulf_50_6 serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen
, 6h
39621
|
Female |
|
|
|
|
|
Male |
4 |
4 |
5 |
5 |
4 |
|
APAP_Glc_50_0 serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen
, baseline
39622
|
Female |
|
|
|
|
|
Male |
4 |
3 |
4 |
5 |
2 |
|
APAP_Glc_50_0.5 serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen
, 0.5h
39623
|
Female |
|
|
|
|
|
Male |
5 |
4 |
4 |
5 |
5 |
|
APAP_Glc_50_1 serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen
, 1h
39624
|
Female |
|
|
|
|
|
Male |
5 |
4 |
5 |
5 |
5 |
|
APAP_Glc_50_2 serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen
, 2h
39625
|
Female |
|
|
|
|
|
Male |
5 |
4 |
5 |
5 |
5 |
|
APAP_Glc_50_3 serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen
, 3h
39626
|
Female |
|
|
|
|
|
Male |
5 |
3 |
5 |
5 |
4 |
|
APAP_Glc_50_6 serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen
, 6h
39627
|
Female |
|
|
|
|
|
Male |
3 |
4 |
5 |
4 |
2 |
|
ALT_Rx300 alanine transaminase (serum ALT)
, dose: 300 mg/kg
39628
|
Female |
|
|
|
|
|
Male |
5 |
5 |
5 |
4 |
4 |
|
GSH_Rx300 reduced glutathione (GSH)
, post-Rx 300 mg/kg
39629
|
Female |
|
|
|
|
|
Male |
5 |
5 |
5 |
5 |
5 |
|
GSH_pct_Rx300 percent reduced glutathione
, post-Rx 300 mg/kg
39630
|
Female |
|
|
|
|
|
Male |
5 |
5 |
5 |
5 |
5 |
|
GSH_total_Rx300 total glutathione
, post-Rx 300 mg/kg
39631
|
Female |
|
|
|
|
|
Male |
5 |
5 |
5 |
5 |
5 |
|
APAP300_0 serum acetaminophen (APAP), 300 mg/mL dose acetaminophen
, baseline
39632
|
Female |
|
|
|
|
|
Male |
5 |
5 |
5 |
4 |
5 |
|
APAP300_0.5 serum acetaminophen (APAP), 300 mg/mL dose acetaminophen
, 0.5h
39633
|
Female |
|
|
|
|
|
Male |
5 |
5 |
5 |
4 |
5 |
|
APAP300_1 serum acetaminophen (APAP), 300 mg/mL dose acetaminophen
, 1h
39634
|
Female |
|
|
|
|
|
Male |
5 |
5 |
5 |
4 |
5 |
|
APAP300_2 serum acetaminophen (APAP), 300 mg/mL dose acetaminophen
, 2h
39635
|
Female |
|
|
|
|
|
Male |
5 |
5 |
5 |
4 |
5 |
|
APAP300_3 serum acetaminophen (APAP), 300 mg/mL dose acetaminophen
, 3h
39636
|
Female |
|
|
|
|
|
Male |
5 |
5 |
5 |
4 |
4 |
|
APAP300_6 serum acetaminophen (APAP), 300 mg/mL dose acetaminophen
, 6h
39637
|
Female |
|
|
|
|
|
Male |
5 |
5 |
5 |
4 |
5 |
|
APAP_Sulf_300_0 serum acetaminophen sulfate (APAP-sulfate), 300 mg/mL dose acetaminophen
, baseline
39638
|
Female |
|
|
|
|
|
Male |
5 |
5 |
5 |
4 |
5 |
|
APAP_Glc_300_0 serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen
, baseline
39639
|
Female |
|
|
|
|
|
Male |
5 |
5 |
5 |
4 |
5 |
|
APAP_Sulf_300_0.5 serum acetaminophen sulfate (APAP-sulfate), 300 mg/mL dose acetaminophen
, 0.5h
39640
|
Female |
|
|
|
|
|
Male |
5 |
5 |
5 |
4 |
5 |
|
APAP_Sulf_300_1 serum acetaminophen sulfate (APAP-sulfate), 300 mg/mL dose acetaminophen
, 1h
39641
|
Female |
|
|
|
|
|
Male |
5 |
5 |
5 |
4 |
5 |
|
APAP_Sulf_300_2 serum acetaminophen sulfate (APAP-sulfate), 300 mg/mL dose acetaminophen
, 2h
39642
|
Female |
|
|
|
|
|
Male |
5 |
5 |
5 |
4 |
5 |
|
APAP_Sulf_300_3 serum acetaminophen sulfate (APAP-sulfate), 300 mg/mL dose acetaminophen
, 3h
39643
|
Female |
|
|
|
|
|
Male |
5 |
5 |
5 |
4 |
4 |
|
APAP_Sulf_300_6 serum acetaminophen sulfate (APAP-sulfate), 300 mg/mL dose acetaminophen
, 6h
39644
|
Female |
|
|
|
|
|
Male |
5 |
5 |
5 |
3 |
5 |
|
APAP_Glc_300_0.5 serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen
, 0.5h
39645
|
Female |
|
|
|
|
|
Male |
5 |
5 |
5 |
4 |
5 |
|
APAP_Glc_300_1 serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen
, 1h
39646
|
Female |
|
|
|
|
|
Male |
5 |
5 |
5 |
4 |
5 |
|
APAP_Glc_300_2 serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen
, 2h
39647
|
Female |
|
|
|
|
|
Male |
5 |
5 |
5 |
4 |
5 |
|
APAP_Glc_300_3 serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen
, 3h
39648
|
Female |
|
|
|
|
|
Male |
5 |
5 |
5 |
4 |
4 |
|
APAP_Glc_300_6 serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen
, 6h
39649
|
Female |
|
|
|
|
|
Male |
5 |
5 |
5 |
3 |
5 |
|