Project measure / variable:   Threadgill2   APAP_Glc_300_1

ID, description, units MPD:39646   APAP_Glc_300_1   serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen   [µg/mL]  1h  
acetaminophen study
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Threadgill2 - serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen 1h



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested5 strains
Mean of the strain means373   µg/mL
Median of the strain means357   µg/mL
SD of the strain means± 44.0
Coefficient of variation (CV)0.118
Min–max range of strain means334   –   443   µg/mL
Mean sample size per strain4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 4 38063.5 9515.875 1.2205 0.3351
Residuals 19 148139.0 7796.7895


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
C3H/HeJ m 334.0 48.8   5 21.8 0.146 280.0, 407.0 -0.89
C57BL/6J m 443.0 94.5   5 42.3 0.213 332.0, 573.0 1.59
DBA/2J m 388.0 99.8   5 44.6 0.257 272.0, 543.0 0.34
LP/J m 344.0 84.4   4 42.2 0.246 265.0, 452.0 -0.66
NZW/LacJ m 357.0 102.0   5 45.7 0.286 197.0, 469.0 -0.37


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
C3H/HeJ m 333.6 39.4887 416.2508 250.9492
C57BL/6J m 442.8 39.4887 525.4508 360.1492
DBA/2J m 388.4 39.4887 471.0508 305.7492
LP/J m 343.5 44.1497 435.9064 251.0936
NZW/LacJ m 356.8 39.4887 439.4508 274.1492




  GWAS USING LINEAR MIXED MODELS