Project measure / variable:   Threadgill2   APAP_Glc_300_3

ID, description, units MPD:39648   APAP_Glc_300_3   serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen   [µg/mL]  3h  
acetaminophen study
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Threadgill2 - serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen 3h



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested5 strains
Mean of the strain means126   µg/mL
Median of the strain means118   µg/mL
SD of the strain means± 47.0
Coefficient of variation (CV)0.373
Min–max range of strain means85.3   –   206   µg/mL
Mean sample size per strain4.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 4 36712.2873 9178.0718 2.9471 0.049
Residuals 18 56056.731 3114.2628


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
C3H/HeJ m 85.3 39.7   5 17.8 0.466 29.2, 125.0 -0.86
C57BL/6J m 118.0 67.2   5 30.1 0.568 21.8, 197.0 -0.17
DBA/2J m 120.0 23.7   5 10.6 0.197 95.0, 156.0 -0.12
LP/J m 206.0 87.1   4 43.6 0.424 88.9, 283.0 1.71
NZW/LacJ m 100.0 47.1   4 23.5 0.47 49.5, 152.0 -0.55


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
C3H/HeJ m 85.28 24.957 137.7127 32.8473
C57BL/6J m 118.32 24.957 170.7527 65.8873
DBA/2J m 120.2 24.957 172.6327 67.7673
LP/J m 205.725 27.9028 264.3466 147.1034
NZW/LacJ m 100.175 27.9028 158.7966 41.5534




  GWAS USING LINEAR MIXED MODELS