Project measure / variable:   Threadgill2   APAP300_0.5

ID, description, units MPD:39633   APAP300_0.5   serum acetaminophen (APAP), 300 mg/mL dose acetaminophen   [µg/mL]  0.5h  
acetaminophen study
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Threadgill2 - serum acetaminophen (APAP), 300 mg/mL dose acetaminophen 0.5h



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested5 strains
Mean of the strain means81.9   µg/mL
Median of the strain means91.0   µg/mL
SD of the strain means± 33.8
Coefficient of variation (CV)0.413
Min–max range of strain means47.3   –   128   µg/mL
Mean sample size per strain4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 4 20695.595 5173.8988 10.4725 0.0001
Residuals 19 9386.8831 494.0465


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
C3H/HeJ m 49.6 11.9   5 5.32 0.24 31.0, 62.8 -0.95
C57BL/6J m 93.4 18.1   5 8.12 0.194 70.5, 117.0 0.34
DBA/2J m 91.0 23.2   5 10.4 0.255 72.1, 127.0 0.27
LP/J m 128.0 30.7   4 15.4 0.24 94.2, 165.0 1.36
NZW/LacJ m 47.3 25.1   5 11.2 0.531 6.92, 71.1 -1.02


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
C3H/HeJ m 49.64 9.9403 70.4453 28.8347
C57BL/6J m 93.38 9.9403 114.1853 72.5747
DBA/2J m 91.0 9.9403 111.8053 70.1947
LP/J m 128.05 11.1136 151.311 104.789
NZW/LacJ m 47.284 9.9403 68.0893 26.4787




  GWAS USING LINEAR MIXED MODELS