Project measure / variable:   Threadgill2   APAP_Glc_50_0

ID, description, units MPD:39622   APAP_Glc_50_0   serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen   [µg/mL]  baseline  
acetaminophen study
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Threadgill2 - serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen baseline



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested5 strains
Mean of the strain means2.65   µg/mL
Median of the strain means2.45   µg/mL
SD of the strain means± 0.972
Coefficient of variation (CV)0.367
Min–max range of strain means1.82   –   4.31   µg/mL
Mean sample size per strain3.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 4 12.2138 3.0534 2.4857 0.0951
Residuals 13 15.9693 1.2284


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
C3H/HeJ m 1.82 0.502   4 0.251 0.276 1.23, 2.45 -0.85
C57BL/6J m 4.31 1.78   3 1.03 0.413 2.51, 6.07 1.71
DBA/2J m 2.12 1.18   4 0.59 0.556 1.22, 3.83 -0.54
LP/J m 2.45 0.927   5 0.415 0.378 0.84, 3.19 -0.2
NZW/LacJ m 2.54 1.12   2   0.795 0.444 1.74, 3.33 -0.11


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
C3H/HeJ m 1.82 0.5542 3.0172 0.6228
C57BL/6J m 4.31 0.6399 5.6924 2.9276
DBA/2J m 2.12 0.5542 3.3172 0.9228
LP/J m 2.45 0.4957 3.5208 1.3792
NZW/LacJ m 2.535 0.7837 4.2281 0.8419




  GWAS USING LINEAR MIXED MODELS