Project measure / variable:   Threadgill2   APAP_Glc_50_6

ID, description, units MPD:39627   APAP_Glc_50_6   serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen   [µg/mL]  6h  
acetaminophen study
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Threadgill2 - serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen 6h



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested5 strains
Mean of the strain means3.60   µg/mL
Median of the strain means3.24   µg/mL
SD of the strain means± 2.38
Coefficient of variation (CV)0.662
Min–max range of strain means0.800   –   7.41   µg/mL
Mean sample size per strain3.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 4 73.2728 18.3182 1.5436 0.2474
Residuals 13 154.2727 11.8671


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
C3H/HeJ m 3.17 3.82   3 2.2 1.2 0.11, 7.45 -0.18
C57BL/6J m 7.41 5.95   4 2.97 0.803 1.11, 14.1 1.6
DBA/2J m 3.24 1.62   5 0.724 0.5 2.07, 6.03 -0.15
LP/J m 3.38 1.67   4 0.836 0.494 1.02, 4.75 -0.09
NZW/LacJ m 0.8 0.269   2   0.19 0.336 0.61, 0.99 -1.17


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
C3H/HeJ m 3.1733 1.9889 7.4701 0.0
C57BL/6J m 7.4075 1.7224 11.1286 3.6864
DBA/2J m 3.238 1.5406 6.5662 0.0
LP/J m 3.3825 1.7224 7.1036 0.0
NZW/LacJ m 0.8 2.4359 6.0624 0.0




  GWAS USING LINEAR MIXED MODELS