Project measure / variable:   Threadgill2   ALT_Rx50

ID, description, units MPD:39602   ALT_Rx50   alanine transaminase (serum ALT)   [IU/L]  dose: 50 mg/kg  
acetaminophen study
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Threadgill2 - alanine transaminase (serum ALT) dose: 50 mg/kg



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested5 strains
Mean of the strain means40.0   IU/L
Median of the strain means38.2   IU/L
SD of the strain means± 9.28
Coefficient of variation (CV)0.232
Min–max range of strain means28.2   –   53.6   IU/L
Mean sample size per strain4.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 4 1707.7543 426.9386 3.1788 0.0385
Residuals 18 2417.55 134.3083


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
C3H/HeJ m 53.6 17.5   5 7.81 0.326 39.0, 74.0 1.47
C57BL/6J m 38.2 3.3   4 1.65 0.0864 36.0, 43.0 -0.19
DBA/2J m 42.8 14.1   5 6.32 0.33 26.0, 65.0 0.31
LP/J m 28.2 5.02   5 2.24 0.178 22.0, 36.0 -1.27
NZW/LacJ m 37.0 9.42   4 4.71 0.254 25.0, 45.0 -0.32


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
C3H/HeJ m 53.6 5.1828 64.4887 42.7113
C57BL/6J m 38.25 5.7946 50.4239 26.0761
DBA/2J m 42.8 5.1828 53.6887 31.9113
LP/J m 28.2 5.1828 39.0887 17.3113
NZW/LacJ m 37.0 5.7946 49.1739 24.8261




  GWAS USING LINEAR MIXED MODELS