Project measure / variable:   Threadgill2   APAP_Glc_50_1

ID, description, units MPD:39624   APAP_Glc_50_1   serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen   [µg/mL]  1h  
acetaminophen study
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Threadgill2 - serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen 1h



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested5 strains
Mean of the strain means23.6   µg/mL
Median of the strain means21.1   µg/mL
SD of the strain means± 9.14
Coefficient of variation (CV)0.387
Min–max range of strain means15.0   –   36.6   µg/mL
Mean sample size per strain4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 4 1635.0879 408.772 1.5559 0.2266
Residuals 19 4991.7853 262.7255


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
C3H/HeJ m 36.6 21.8   5 9.76 0.597 19.8, 66.1 1.42
C57BL/6J m 29.1 22.4   4 11.2 0.769 9.22, 60.5 0.6
DBA/2J m 21.1 16.6   5 7.44 0.789 6.64, 47.2 -0.27
LP/J m 16.2 2.59   5 1.16 0.16 14.3, 20.7 -0.81
NZW/LacJ m 15.0 10.6   5 4.76 0.709 -0.94


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
C3H/HeJ m 36.58 7.2488 51.7519 21.4081
C57BL/6J m 29.08 8.1044 46.0427 12.1173
DBA/2J m 21.068 7.2488 36.2399 5.8961
LP/J m 16.2 7.2488 31.3719 1.0281
NZW/LacJ m 15.02 7.2488 30.1919 0.0




  GWAS USING LINEAR MIXED MODELS