Project measure / variable:   Threadgill2   APAP_Glc_50_0.5

ID, description, units MPD:39623   APAP_Glc_50_0.5   serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen   [µg/mL]  0.5h  
acetaminophen study
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Ontology mappings

  STRAIN COMPARISON PLOT
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Threadgill2 - serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen 0.5h



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested5 strains
Mean of the strain means29.9   µg/mL
Median of the strain means26.0   µg/mL
SD of the strain means± 13.1
Coefficient of variation (CV)0.440
Min–max range of strain means20.0   –   52.0   µg/mL
Mean sample size per strain4.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 4 2946.08 736.52 1.4588 0.2559
Residuals 18 9087.5745 504.8652


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
C3H/HeJ m 20.0 26.7   5 12.0 1.34 2.04, 66.0 -0.75
C57BL/6J m 52.0 41.8   4 20.9 0.805 18.8, 108.0 1.68
DBA/2J m 26.0 8.91   4 4.46 0.343 20.7, 39.3 -0.3
LP/J m 31.0 9.17   5 4.1 0.296 18.6, 44.4 0.08
NZW/LacJ m 20.5 10.0   5 4.47 0.489 7.92, 29.7 -0.72


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
C3H/HeJ m 19.952 10.0485 41.0632 0.0
C57BL/6J m 52.0 11.2346 75.603 28.397
DBA/2J m 25.975 11.2346 49.578 2.372
LP/J m 31.0 10.0485 52.1112 9.8888
NZW/LacJ m 20.464 10.0485 41.5752 0.0




GWAS analysis not available: At least 12 strains are required