Project measure / variable:   Threadgill2   APAP300_6

ID, description, units MPD:39637   APAP300_6   serum acetaminophen (APAP), 300 mg/mL dose acetaminophen   [µg/mL]  6h  
acetaminophen study
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Threadgill2 - serum acetaminophen (APAP), 300 mg/mL dose acetaminophen 6h



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested5 strains
Mean of the strain means4.53   µg/mL
Median of the strain means2.74   µg/mL
SD of the strain means± 5.17
Coefficient of variation (CV)1.14
Min–max range of strain means0.952   –   13.6   µg/mL
Mean sample size per strain4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 4 450.348 112.587 2.0634 0.1259
Residuals 19 1036.714 54.5639


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
C3H/HeJ m 0.952 0.614   5 0.274 0.645 0.51, 2.03 -0.69
C57BL/6J m 1.73 1.55   5 0.692 0.893 0.2, 4.29 -0.54
DBA/2J m 2.74 1.53   5 0.682 0.558 0.95, 4.87 -0.35
LP/J m 13.6 18.2   4 9.09 1.34 4.47, 40.9 1.75
NZW/LacJ m 3.61 2.44   5 1.09 0.676 1.16, 6.64 -0.18


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
C3H/HeJ m 0.952 3.3034 7.8662 0.0
C57BL/6J m 1.732 3.3034 8.6462 0.0
DBA/2J m 2.736 3.3034 9.6502 0.0
LP/J m 13.6175 3.6934 21.3478 5.8872
NZW/LacJ m 3.612 3.3034 10.5262 0.0




  GWAS USING LINEAR MIXED MODELS