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Project measure / variable:   Threadgill2   APAP_Glc_50_2

ID, description, units MPD:39625   APAP_Glc_50_2   serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen   [µg/mL]  2h  
acetaminophen study
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Threadgill2 - serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen 2h



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested5 strains
Mean of the strain means8.81   µg/mL
Median of the strain means8.10   µg/mL
SD of the strain means± 3.66
Coefficient of variation (CV)0.415
Min–max range of strain means4.95   –   13.7   µg/mL
Mean sample size per strain4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 4 265.867 66.4667 0.6575 0.6289
Residuals 19 1920.7032 101.0896


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
C3H/HeJ m 13.7 13.2   5 5.89 0.962 1.63, 31.1 1.34
C57BL/6J m 8.1 7.77   4 3.89 0.96 2.79, 19.6 -0.19
DBA/2J m 11.3 15.9   5 7.09 1.41 1.69, 39.3 0.68
LP/J m 4.95 1.98   5 0.885 0.4 1.73, 6.99 -1.06
NZW/LacJ m 5.99 2.5   5 1.12 0.417 3.09, 8.86 -0.77


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
C3H/HeJ m 13.688 4.4964 23.0991 4.2769
C57BL/6J m 8.1 5.0272 18.622 0.0
DBA/2J m 11.274 4.4964 20.6851 1.8629
LP/J m 4.946 4.4964 14.3571 0.0
NZW/LacJ m 5.986 4.4964 15.3971 0.0




  GWAS USING LINEAR MIXED MODELS