Project measure / variable:   Threadgill2   APAP_Sulf_50_0

ID, description, units MPD:39616   APAP_Sulf_50_0   serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen   [µg/mL]  baseline  
acetaminophen study
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Threadgill2 - serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen baseline



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested5 strains
Mean of the strain means1.66   µg/mL
Median of the strain means2.05   µg/mL
SD of the strain means± 0.671
Coefficient of variation (CV)0.404
Min–max range of strain means0.646   –   2.17   µg/mL
Mean sample size per strain4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 4 8.718 2.1795 1.5825 0.2197
Residuals 19 26.1683 1.3773


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
C3H/HeJ m 2.14 1.74   5 0.776 0.811 0.46, 4.32 0.71
C57BL/6J m 2.17 1.75   4 0.873 0.806 0.64, 3.87 0.76
DBA/2J m 1.3 0.881   5 0.394 0.678 0.25, 2.33 -0.54
LP/J m 0.646 0.322   5 0.144 0.498 0.12, 0.91 -1.51
NZW/LacJ m 2.05 0.603   5 0.27 0.294 1.5, 2.84 0.58


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
C3H/HeJ m 2.14 0.5248 3.2385 1.0415
C57BL/6J m 2.165 0.5868 3.3932 0.9368
DBA/2J m 1.298 0.5248 2.3965 0.1995
LP/J m 0.646 0.5248 1.7445 0.0
NZW/LacJ m 2.05 0.5248 3.1485 0.9515




  GWAS USING LINEAR MIXED MODELS