Project measure / variable:   Threadgill2   APAP_Glc_300_0.5

ID, description, units MPD:39645   APAP_Glc_300_0.5   serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen   [µg/mL]  0.5h  
acetaminophen study
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Ontology mappings

  STRAIN COMPARISON PLOT
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Threadgill2 - serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen 0.5h



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested5 strains
Mean of the strain means285   µg/mL
Median of the strain means261   µg/mL
SD of the strain means± 66.2
Coefficient of variation (CV)0.232
Min–max range of strain means220   –   384   µg/mL
Mean sample size per strain4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 4 83666.5521 20916.638 3.8547 0.0186
Residuals 19 103099.6675 5426.2983


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
C3H/HeJ m 242.0 27.3   5 12.2 0.113 207.0, 279.0 -0.65
C57BL/6J m 318.0 50.9   5 22.8 0.16 231.0, 357.0 0.5
DBA/2J m 384.0 58.1   5 26.0 0.151 312.0, 469.0 1.5
LP/J m 220.0 137.0   4 68.7 0.626 32.7, 345.0 -0.98
NZW/LacJ m 261.0 69.8   5 31.2 0.268 143.0, 328.0 -0.36


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
C3H/HeJ m 242.4 32.9433 311.3511 173.4489
C57BL/6J m 317.6 32.9433 386.5511 248.6489
DBA/2J m 384.4 32.9433 453.3511 315.4489
LP/J m 219.675 36.8317 296.7646 142.5854
NZW/LacJ m 260.6 32.9433 329.5511 191.6489




GWAS analysis not available: At least 12 strains are required