Project measure / variable:   Threadgill2   APAP_Sulf_300_0.5

ID, description, units MPD:39640   APAP_Sulf_300_0.5   serum acetaminophen sulfate (APAP-sulfate), 300 mg/mL dose acetaminophen   [µg/mL]  0.5h  
acetaminophen study
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Threadgill2 - serum acetaminophen sulfate (APAP-sulfate), 300 mg/mL dose acetaminophen 0.5h



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested5 strains
Mean of the strain means17.3   µg/mL
Median of the strain means17.8   µg/mL
SD of the strain means± 2.70
Coefficient of variation (CV)0.156
Min–max range of strain means13.2   –   20.4   µg/mL
Mean sample size per strain4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 4 147.8583 36.9646 2.3356 0.0925
Residuals 19 300.7 15.8263


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
C3H/HeJ m 13.2 3.96   5 1.77 0.301 10.6, 19.9 -1.52
C57BL/6J m 16.5 3.2   5 1.43 0.194 12.1, 20.1 -0.3
DBA/2J m 20.4 5.46   5 2.44 0.268 13.8, 26.7 1.14
LP/J m 17.8 2.08   4 1.04 0.117 15.3, 20.3 0.18
NZW/LacJ m 18.7 4.02   5 1.8 0.215 12.3, 23.4 0.51


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
C3H/HeJ m 13.16 1.7791 16.8837 9.4363
C57BL/6J m 16.48 1.7791 20.2037 12.7563
DBA/2J m 20.38 1.7791 24.1037 16.6563
LP/J m 17.8 1.9891 21.9633 13.6367
NZW/LacJ m 18.74 1.7791 22.4637 15.0163




  GWAS USING LINEAR MIXED MODELS