Project measure / variable:   Threadgill2   APAP300_1

ID, description, units MPD:39634   APAP300_1   serum acetaminophen (APAP), 300 mg/mL dose acetaminophen   [µg/mL]  1h  
acetaminophen study
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Threadgill2 - serum acetaminophen (APAP), 300 mg/mL dose acetaminophen 1h



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested5 strains
Mean of the strain means62.5   µg/mL
Median of the strain means56.3   µg/mL
SD of the strain means± 25.6
Coefficient of variation (CV)0.410
Min–max range of strain means36.8   –   99.1   µg/mL
Mean sample size per strain4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 4 11731.1209 2932.7802 4.4244 0.0107
Residuals 19 12594.5329 662.8702


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
C3H/HeJ m 43.2 14.4   5 6.45 0.334 21.9, 58.1 -0.75
C57BL/6J m 77.2 21.2   5 9.5 0.275 54.6, 107.0 0.57
DBA/2J m 56.3 31.9   5 14.3 0.566 4.89, 92.4 -0.24
LP/J m 99.1 37.2   4 18.6 0.375 61.6, 138.0 1.43
NZW/LacJ m 36.8 20.9   5 9.34 0.568 6.25, 62.1 -1.0


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
C3H/HeJ m 43.24 11.5141 67.3392 19.1408
C57BL/6J m 77.24 11.5141 101.3392 53.1408
DBA/2J m 56.338 11.5141 80.4372 32.2388
LP/J m 99.05 12.8731 125.9938 72.1062
NZW/LacJ m 36.77 11.5141 60.8692 12.6708




  GWAS USING LINEAR MIXED MODELS