Project measure / variable:   Threadgill2   APAP50_3

ID, description, units MPD:39614   APAP50_3   serum acetaminophen (APAP), 50 mg/mL dose acetaminophen   [µg/mL]  3h  
acetaminophen study
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Threadgill2 - serum acetaminophen (APAP), 50 mg/mL dose acetaminophen 3h



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested5 strains
Mean of the strain means0.578   µg/mL
Median of the strain means0.520   µg/mL
SD of the strain means± 0.210
Coefficient of variation (CV)0.364
Min–max range of strain means0.297   –   0.814   µg/mL
Mean sample size per strain4.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 4 0.7817 0.1954 0.854 0.5109
Residuals 17 3.8905 0.2289


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
C3H/HeJ m 0.814 0.509   5 0.227 0.625 0.21, 1.34 1.12
C57BL/6J m 0.5 0.399   3 0.23 0.798 0.19, 0.95 -0.37
DBA/2J m 0.758 0.708   5 0.317 0.934 0.06, 1.6 0.86
LP/J m 0.52 0.275   5 0.123 0.53 0.07, 0.81 -0.28
NZW/LacJ m 0.297 0.276   4 0.138 0.928 -1.34


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
C3H/HeJ m 0.814 0.2139 1.2654 0.3626
C57BL/6J m 0.5 0.2762 1.0827 0.0
DBA/2J m 0.758 0.2139 1.2094 0.3066
LP/J m 0.52 0.2139 0.9714 0.0686
NZW/LacJ m 0.2975 0.2392 0.8022 0.0




  GWAS USING LINEAR MIXED MODELS