Project measure / variable:   Threadgill2   APAP_Glc_300_6

ID, description, units MPD:39649   APAP_Glc_300_6   serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen   [µg/mL]  6h  
acetaminophen study
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Threadgill2 - serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen 6h



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested5 strains
Mean of the strain means32.0   µg/mL
Median of the strain means28.3   µg/mL
SD of the strain means± 19.6
Coefficient of variation (CV)0.610
Min–max range of strain means10.7   –   63.8   µg/mL
Mean sample size per strain4.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 4 5453.434 1363.3585 8.7759 0.0004
Residuals 18 2796.3343 155.3519


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
C3H/HeJ m 10.7 3.39   5 1.52 0.318 8.3, 16.5 -1.09
C57BL/6J m 32.5 20.4   5 9.13 0.629 19.5, 68.5 0.02
DBA/2J m 28.3 12.9   5 5.78 0.457 15.2, 48.1 -0.19
LP/J m 63.8 6.91   3 3.99 0.108 58.2, 71.5 1.62
NZW/LacJ m 24.9 8.95   5 4.0 0.36 14.2, 36.6 -0.37


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
C3H/HeJ m 10.668 5.5741 22.3787 0.0
C57BL/6J m 32.46 5.5741 44.1707 20.7493
DBA/2J m 28.26 5.5741 39.9707 16.5493
LP/J m 63.7667 7.1961 78.8851 48.6482
NZW/LacJ m 24.86 5.5741 36.5707 13.1493




  GWAS USING LINEAR MIXED MODELS