MPD: Measures involving drug and metabolite quantification

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)	Year
Crabbe2:1	Crabbe2	drug and metabolite quantification	diazepam	brain diazepam and metabolite concentration, 30 min post-injection [ng/g] brain_DZ 15501 8 mg/kg 16 mg/kg	inbred	15	m	6-7wks	N=8	1998

Crabbe2:3	Crabbe2	drug and metabolite quantification	diazepam	brain diazepam and metabolite concentration, <5 min post-injection, after rotarod [ng/g] brain_DZ20 15503 trial block1 trial block2	inbred	15	m	6-7wks	N=13	1998

Crowley1:3	Crowley1	drug and metabolite quantification	haloperidol	plasma haloperidol concentration [nM] haloperidol 39403 day: 30 60 90 120	inbred w/CC8	27	m	9-28wks	N=6	2012

Gould1:5	Gould1	drug and metabolite quantification	lithium	serum lithium concentration [mmol/L] blood_lithium 37405 lithium dose [mg/kg]: 200 300 400	inbred	11	m	7-8wks	N=8	2011

Gould1:8	Gould1	drug and metabolite quantification	lithium	brain lithium concentration [mmol/L] brain_lithium 37408 lithium dose [mg/kg]: 200 300 400	inbred	11	m	7-8wks	N=8	2011

Gould2:1	Gould2	drug and metabolite quantification	nicotine	plasma nicotine [ng/mL] nicotine 47101 acute 0.09mg dose chronic 6.3mg dose	inbred	8	m	8-12wks	N=10	2011

Gould2:3	Gould2	drug and metabolite quantification	nicotine	plasma cotinine [ng/mL] cotinine 47105 acute 0.09mg dose chronic 6.3mg dose	inbred	8	m	8-12wks	N=10	2011

Harrill2:55	Harrill2	drug and metabolite quantification	DB289	kidney metabolite (DB75) concentration [µM] kidney_DB75 44155 control DB289	inbred	34	f	6-8wks	N=4	2012

Rusyn2:67	Rusyn2	drug and metabolite quantification	trichloroethylene	dichloroacetic acid (serum DCA x 10^-3) [nmol/mL] DCA_tce 36167 time after treatment: 2h 8h 24h	inbred	15	m	7wks	N=3	2010

Rusyn2:75	Rusyn2	drug and metabolite quantification	trichloroethylene	trichloroacetic acid (serum TCA) [nmol/mL] TCA_tce 36175 time after treatment: 2h 8h 24h	inbred	15	m	7wks	N=3	2010

Rusyn2:85	Rusyn2	drug and metabolite quantification	trichloroethylene	DCV cysteine (serum DCVC x 10^-3) [nmol/mL] DCV_cysteine_tce 36185 time after treatment: 2h 8h 24h	inbred	16	m	7wks	N=2	2010

Rusyn2:95	Rusyn2	drug and metabolite quantification	trichloroethylene	DCV glutathione (serum DCVG x 10^-3) [nmol/mL] DCV_glutathione_tce 36195 time after treatment: 2h 8h 24h	inbred	17	m	7wks	N=2	2010

Rusyn6:2	Rusyn6	drug and metabolite quantification	trichloroethylene	trichloroacetic acid (serum TCA) [nmol/mL] TCA_serum_tce 51202	inbred	7	m	6-7wks	N=3	2014

Rusyn6:4	Rusyn6	drug and metabolite quantification	trichloroethylene	dichloroacetic acid (serum DCA) [nmol/mL] DCA_serum_tce 51204	inbred	7	m	6-7wks	N=3	2014

Rusyn6:6	Rusyn6	drug and metabolite quantification	trichloroethylene	S-(1,2-dichlorovinyl) glutathione (serum DCVG) [pmol/mL] DCVG_serum_tce 51206	inbred	4	m	6-7wks	N=2	2014

Rusyn6:8	Rusyn6	drug and metabolite quantification	trichloroethylene	S-(1,2-dichlorovinyl)-L-cysteine (serum DCVC) [pmol/mL] DCVC_serum_tce 51208	inbred	7	m	6-7wks	N=3	2014

Rusyn6:16	Rusyn6	drug and metabolite quantification	trichloroethylene	trichloroacetic acid (liver TCA) [nmol/g] TCA_liver_tce 51216	inbred	7	m	6-7wks	N=4	2014

Rusyn6:18	Rusyn6	drug and metabolite quantification	trichloroethylene	dichloroacetic acid (liver DCA) [nmol/g] DCA_liver_tce 51218	inbred	7	m	6-7wks	N=4	2014

Rusyn6:20	Rusyn6	drug and metabolite quantification	trichloroethylene	trichloroethanol (liver TCOH) [nmol/g] TCOH_liver_tce 51220	inbred	7	m	6-7wks	N=4	2014

Rusyn6:22	Rusyn6	drug and metabolite quantification	trichloroethylene	S-(1,2-dichlorovinyl) glutathione (liver DCVG) [pmol/g] DCVG_liver_tce 51222	inbred	7	m	6-7wks	N=4	2014

Rusyn6:58	Rusyn6	drug and metabolite quantification	trichloroethylene	trichloroacetic acid (kidney TCA) [nmol/g] TCA_kidney_tce 51258	inbred	7	m	6-7wks	N=4	2014

Rusyn6:60	Rusyn6	drug and metabolite quantification	trichloroethylene	dichloroacetic acid (kidney DCA) [nmol/g] DCA_kidney_tce 51260	inbred	6	m	6-7wks	N=3	2014

Rusyn6:62	Rusyn6	drug and metabolite quantification	trichloroethylene	trichloroethanol (kidney TCOH) [nmol/g] TCOH_kidney_tce 51262	inbred	7	m	6-7wks	N=4	2014

Rusyn6:64	Rusyn6	drug and metabolite quantification	trichloroethylene	S-(1,2-dichlorovinyl) glutathione (kidney DCVG) [pmol/g] DCVG_kidney_tce 51264	inbred	6	m	6-7wks	N=2	2014

Rusyn6:66	Rusyn6	drug and metabolite quantification	trichloroethylene	S-(1,2-dichlorovinyl)-L-cysteine (kidney DCVC) [pmol/g] DCVC_kidney_tce 51266	inbred	6	m	6-7wks	N=2	2014

Threadgill2:9	Threadgill2	drug and metabolite quantification	acetaminophen	serum acetaminophen (APAP), 50 mg/mL dose acetaminophen [µg/mL] APAP50 39609 baseline 0.5h 1h 2h 3h 6h	inbred	5	m	6-8wks	N=5	2005

Threadgill2:16	Threadgill2	drug and metabolite quantification	acetaminophen	serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen [µg/mL] APAP_Sulf_50 39616 baseline 0.5h 1h 2h 3h 6h	inbred	5	m	6-8wks	N=5	2005

Threadgill2:22	Threadgill2	drug and metabolite quantification	acetaminophen	serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen [µg/mL] APAP_Glc_50 39622 baseline 0.5h 1h 2h 3h 6h	inbred	5	m	6-8wks	N=4	2005

Threadgill2:32	Threadgill2	drug and metabolite quantification	acetaminophen	serum acetaminophen (APAP), 300 mg/mL dose acetaminophen [µg/mL] APAP300 39632 baseline 0.5h 1h 2h 3h 6h	inbred	5	m	6-8wks	N=5	2005

Threadgill2:38	Threadgill2	drug and metabolite quantification	acetaminophen	serum acetaminophen sulfate (APAP-sulfate), 300 mg/mL dose acetaminophen [µg/mL] APAP_Sulf_300 39638 baseline 0.5h 1h 2h 3h 6h	inbred	5	m	6-8wks	N=5	2005

Threadgill2:39	Threadgill2	drug and metabolite quantification	acetaminophen	serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen [µg/mL] APAP_Glc_300 39639 baseline 0.5h 1h 2h 3h 6h	inbred	5	m	6-8wks	N=5	2005

Wiltshire2:7	Wiltshire2	drug and metabolite quantification	fluoxetine	drug and metabolite concentration [ng/mL] fluoxetine 38007 fluoxetine norfluoxetine	inbred	30	m	10-11wks	N=11	2011

Xenakis1:36	Xenakis1	drug and metabolite quantification	haloperidol	plasma haloperidol concentration, treatment group, post-treatment [ng/dL] haloperidol_conc_post 111179	CC RIX	53	both	11-13wks	N=2	2020

Crabbe2

drug and metabolite quantification

diazepam

brain diazepam and metabolite concentration, 30 min post-injection [ng/g] brain_DZ 15501 8 mg/kg 16 mg/kg

inbred

15

m

6-7wks

N=8

1998

Crabbe2

drug and metabolite quantification

diazepam

brain diazepam and metabolite concentration, <5 min post-injection, after rotarod [ng/g] brain_DZ20 15503 trial block1 trial block2

inbred

15

m

6-7wks

N=13

1998

Crowley1

drug and metabolite quantification

haloperidol

plasma haloperidol concentration [nM] haloperidol 39403 day: 30 60 90 120

inbred w/CC8

27

m

9-28wks

N=6

2012

Gould1

drug and metabolite quantification

lithium

serum lithium concentration [mmol/L] blood_lithium 37405 lithium dose [mg/kg]: 200 300 400

inbred

11

m

7-8wks

N=8

2011

Gould1

drug and metabolite quantification

lithium

brain lithium concentration [mmol/L] brain_lithium 37408 lithium dose [mg/kg]: 200 300 400

inbred

11

m

7-8wks

N=8

2011

Gould2

drug and metabolite quantification

nicotine

plasma nicotine [ng/mL] nicotine 47101 acute 0.09mg dose chronic 6.3mg dose

inbred

8

m

8-12wks

N=10

2011

Gould2

drug and metabolite quantification

nicotine

plasma cotinine [ng/mL] cotinine 47105 acute 0.09mg dose chronic 6.3mg dose

inbred

8

m

8-12wks

N=10

2011

Harrill2

drug and metabolite quantification

DB289

kidney metabolite (DB75) concentration [µM] kidney_DB75 44155 control DB289

inbred

34

f

6-8wks

N=4

2012

Rusyn2

drug and metabolite quantification

trichloroethylene

dichloroacetic acid (serum DCA x 10^-3) [nmol/mL] DCA_tce 36167 time after treatment: 2h 8h 24h

inbred

15

m

7wks

N=3

2010

Rusyn2

drug and metabolite quantification

trichloroethylene

trichloroacetic acid (serum TCA) [nmol/mL] TCA_tce 36175 time after treatment: 2h 8h 24h

inbred

15

m

7wks

N=3

2010

Rusyn2

drug and metabolite quantification

trichloroethylene

DCV cysteine (serum DCVC x 10^-3) [nmol/mL] DCV_cysteine_tce 36185 time after treatment: 2h 8h 24h

inbred

16

m

7wks

N=2

2010

Rusyn2

drug and metabolite quantification

trichloroethylene

DCV glutathione (serum DCVG x 10^-3) [nmol/mL] DCV_glutathione_tce 36195 time after treatment: 2h 8h 24h

inbred

17

m

7wks

N=2

2010

Rusyn6

drug and metabolite quantification

trichloroethylene

trichloroacetic acid (serum TCA) [nmol/mL] TCA_serum_tce 51202

inbred

7

m

6-7wks

N=3

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

dichloroacetic acid (serum DCA) [nmol/mL] DCA_serum_tce 51204

inbred

7

m

6-7wks

N=3

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

S-(1,2-dichlorovinyl) glutathione (serum DCVG) [pmol/mL] DCVG_serum_tce 51206

inbred

4

m

6-7wks

N=2

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

S-(1,2-dichlorovinyl)-L-cysteine (serum DCVC) [pmol/mL] DCVC_serum_tce 51208

inbred

7

m

6-7wks

N=3

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

trichloroacetic acid (liver TCA) [nmol/g] TCA_liver_tce 51216

inbred

7

m

6-7wks

N=4

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

dichloroacetic acid (liver DCA) [nmol/g] DCA_liver_tce 51218

inbred

7

m

6-7wks

N=4

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

trichloroethanol (liver TCOH) [nmol/g] TCOH_liver_tce 51220

inbred

7

m

6-7wks

N=4

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

S-(1,2-dichlorovinyl) glutathione (liver DCVG) [pmol/g] DCVG_liver_tce 51222

inbred

7

m

6-7wks

N=4

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

trichloroacetic acid (kidney TCA) [nmol/g] TCA_kidney_tce 51258

inbred

7

m

6-7wks

N=4

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

dichloroacetic acid (kidney DCA) [nmol/g] DCA_kidney_tce 51260

inbred

6

m

6-7wks

N=3

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

trichloroethanol (kidney TCOH) [nmol/g] TCOH_kidney_tce 51262

inbred

7

m

6-7wks

N=4

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

S-(1,2-dichlorovinyl) glutathione (kidney DCVG) [pmol/g] DCVG_kidney_tce 51264

inbred

6

m

6-7wks

N=2

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

S-(1,2-dichlorovinyl)-L-cysteine (kidney DCVC) [pmol/g] DCVC_kidney_tce 51266

inbred

6

m

6-7wks

N=2

2014

Threadgill2

drug and metabolite quantification

acetaminophen

serum acetaminophen (APAP), 50 mg/mL dose acetaminophen [µg/mL] APAP50 39609 baseline 0.5h 1h 2h 3h 6h

inbred

5

m

6-8wks

N=5

2005

Threadgill2

drug and metabolite quantification

acetaminophen

serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen [µg/mL] APAP_Sulf_50 39616 baseline 0.5h 1h 2h 3h 6h

inbred

5

m

6-8wks

N=5

2005

Threadgill2

drug and metabolite quantification

acetaminophen

serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen [µg/mL] APAP_Glc_50 39622 baseline 0.5h 1h 2h 3h 6h

inbred

5

m

6-8wks

N=4

2005

Threadgill2

drug and metabolite quantification

acetaminophen

serum acetaminophen (APAP), 300 mg/mL dose acetaminophen [µg/mL] APAP300 39632 baseline 0.5h 1h 2h 3h 6h

inbred

5

m

6-8wks

N=5

2005

Threadgill2

drug and metabolite quantification

acetaminophen

serum acetaminophen sulfate (APAP-sulfate), 300 mg/mL dose acetaminophen [µg/mL] APAP_Sulf_300 39638 baseline 0.5h 1h 2h 3h 6h

inbred

5

m

6-8wks

N=5

2005

Threadgill2

drug and metabolite quantification

acetaminophen

serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen [µg/mL] APAP_Glc_300 39639 baseline 0.5h 1h 2h 3h 6h

inbred

5

m

6-8wks

N=5

2005

Wiltshire2

drug and metabolite quantification

fluoxetine

drug and metabolite concentration [ng/mL] fluoxetine 38007 fluoxetine norfluoxetine

inbred

30

m

10-11wks

N=11

2011

Xenakis1

drug and metabolite quantification

haloperidol

plasma haloperidol concentration, treatment group, post-treatment [ng/dL] haloperidol_conc_post 111179

CC RIX

53

both

11-13wks

N=2

2020

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