Crabbe2: Drug study: Effects of diazepam on activity, motor coordination, and body temperature, in 15 inbred strains of mice (1998)
Crabbe JC, Gallaher EJ, Cross SJ, Belknap JK. Genetic determinants of sensitivity to diazepam in inbred mice.
Behav Neurosci. 1998 Jun;112(3):668-77.
A investigation of the pharmacogenetic components and behavioral sensitivity to diazepam.
Animals were evaluated at baseline and following diazepam administration
(doses of 2, 4, 8, 16, and 20 mg/kg body weight i.p.)
in the following areas:
multi-system analysis of activity and motor function, coordination and balance, drug metabolism, and
thermal regulation.
Procedures conducted:
Procedures conducted:
| Latency to fall from 5 rpm rotarod immediately after diazepam injection. | ||
| Diazepam (and metabolite) concentration in brain tissue immediately after diazepam injection and rotarod. | ||
| Locomotor activity. Baseline vs. immediately after Diazepam injection (several doses). 15 min test. | ||
| Baseline vs. 30 min after diazepam injection (several doses). |
Ontology terms mapped to Crabbe2 measures:
| Investigators |
John C Crabbe Oregon Health & Science University, Portland, OR Edward J Gallaher Oregon Health & Science University, Portland, OR John K Belknap Oregon Health & Science University, Portland, OR |
| Participants | Cross SJ |
| Contact | John C Crabbe crabbe@ohsu.edu |
| Acknowledgements | Funding provided by NIH DA05228, AA08621, AA10760; Department of Veterans Affairs
Acknowledgements: Jones G, Young E, Phillips E |
| Phenotype strain survey data set | |
| MPD identifiers | Crabbe2 MPD:155 |
| No updates/corrections. Initial release date: 02/2009. | |
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