MPD: Project measures / variables set: Gould2 cotinine

Project measures / variables set: Gould2 cotinine

ID, description, units	MPD:47105 cotinine plasma cotinine [ng/mL] nicotine study
Measures	• acute 0.09mg dose • chronic 6.3mg dose
Data set, strains	Gould2 inbred 8 strains sex: m age: 8-12wks
Procedure	drug and metabolite quantification
Comparison	multiple dosage cohorts but no control group
Ontology mappings	VT:0002121 metabolism trait VT:0010721 response to nicotine trait MA:0002501 plasma MP:0008872 abnormal physiological response to xenobiotic MP:0012695 abnormal nicotine metabolism

Values Means Δ Means Z-scores

Graph Type Points Bars

Dimensions Width: × Height: px

Plot Options Hide Error Bars Strains on X-axis

Data Type:

Dimensions Height: px

Toggle Series

Plot Options Show Standard Error Show Point Labels Flip Axes Shared Tooltip Connect Gaps

Gould2 - plasma cotinine

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
group	1	240027.6595	240027.6595	1001.6465	< 0.0001
group:strain	7	66740.4303	9534.3472	39.7873	< 0.0001
Residuals	140	33548.6339	239.6331
strain	7	87940.9337	12562.9905	52.4259	< 0.0001

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Gould2	47105	drug and metabolite quantification	nicotine	plasma cotinine [ng/mL] acute 0.09mg dose cotinine_acu	inbred	8	m
Gould2	47106	drug and metabolite quantification	nicotine	plasma cotinine [ng/mL] chronic 6.3mg dose cotinine_chr	inbred	8	m