Portugal GS, Wilkinson DS, Kenney JW, Sullivan C, Gould TJ. Strain-dependent Effects of Acute, Chronic, and Withdrawal from Chronic Nicotine on Fear Conditioning.
Behav Genet. 2012 Jan;42(1):133-50. Epub 2011 Aug 6.
George S Portugal Columbia University, New York, NY|
Thomas J Gould Temple University, Philadelphia, PA
|Participants||Wilkinson DS, Kenney JW, Sullivan C|
|Contact||Thomas J Gould firstname.lastname@example.org
|Part of a series:||
nicotine acute and chronic study groups (this project) Gould2
• nicotine withdrawal study group see Gould3
|Acknowledgements||Funding provided by NIH DA017949, DA024787, CA143187|
|Phenotype strain survey data set|
|MPD identifiers||Gould2 MPD:471|
|No updates/corrections. Initial release date: 05/2013.|
Click above to copy-paste the entire citation for this MPD web page.
|Summary of procedures that were conducted|
|• drug and metabolite quantification||Amount of nicotine and cotinine in blood plasma after nicotine doses. High and lower doses.|
|• behavior observation||Observed measures of anxiety. Nicotine (high dose) vs. control. 20 min period.|
|• elevated plus maze||Measures of anxiety. Nicotine (high dose) vs. control. 5 min test.|
|• fear conditioning test||Contextual fear, cued fear. Nicotine (high and several lower doses) vs. control.|