Portugal GS, Wilkinson DS, Kenney JW, Sullivan C, Gould TJ. Strain-dependent Effects of Acute, Chronic, and Withdrawal from Chronic Nicotine on Fear Conditioning.
Behav Genet. 2012 Jan;42(1):133-50. Epub 2011 Aug 6.
Participants |
George S Portugal Columbia University, New York, NY Thomas J Gould Temple University, Philadelphia, PA With: Wilkinson DS, Kenney JW, Sullivan C |
Contact | Thomas J Gould tgould@temple.edu
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Part of a series: |
•
nicotine acute and chronic study groups (this project) Gould2
• nicotine withdrawal study group see Gould3 |
Acknowledgements | Funding provided by NIH DA017949, DA024787, CA143187 |
Phenotype strain survey data set | |
MPD identifiers | Gould2 MPD:471 |
No updates/corrections. Initial release date: 05/2013. | |
Click above to copy-paste the entire citation for this MPD web page. |
Summary of procedures that were conducted | |
• drug and metabolite quantification | Amount of nicotine and cotinine in blood plasma after nicotine doses. High and lower doses. |
• behavior observation | Observed measures of anxiety. Nicotine (high dose) vs. control. 20 min period. |
• elevated plus maze | Measures of anxiety. Nicotine (high dose) vs. control. 5 min test. |
• fear conditioning test | Contextual fear, cued fear. Nicotine (high and several lower doses) vs. control. |