Gould2: Drug study: Effects of acute and chronic nicotine on fear conditioning and other behaviors in males of 8 inbred mouse strains (2011)

Portugal GS, Wilkinson DS, Kenney JW, Sullivan C, Gould TJ. Strain-dependent Effects of Acute, Chronic, and Withdrawal from Chronic Nicotine on Fear Conditioning. Behav Genet. 2012 Jan;42(1):133-50. Epub 2011 Aug 6.   PubMed 21822688  


         
Acute group cohorts include saline controls and nicotine dose groups of 0.045, 0.09, and 0.18 mg/kg. Chronic group cohorts include saline controls and nicotine dose of 12 mg/kg/d administered for 14 days. Plasma assay and fear conditioning assays were done for both acute and chronic groups. EPM and somatic trait observation were done for the chronic group only.



Experimental groups in this study:
• None     • None     • None     • None     • None     • None     • None     • None    

Procedures conducted:

• drug and metabolite quantification  Amount of nicotine and cotinine in blood plasma after nicotine doses. High and lower doses.
• behavior observation  Observed measures of anxiety. Nicotine (high dose) vs. control. 20 min period.
• elevated plus maze  Measures of anxiety. Nicotine (high dose) vs. control. 5 min test.
• fear conditioning test  Contextual fear, cued fear. Nicotine (high and several lower doses) vs. control.

Gould2 downloads
• Download Gould2 project data set     animal data, as uploaded
• Download Gould2 animal data matrix     with factor-related expansion applied as necessary
• Download Gould2 strain means, SD, N, etc.     one row per strain/sex/measure
• Gould2 supplementary data
Investigators George S Portugal       Columbia University,  New York, NY
Thomas J Gould       Temple University,  Philadelphia, PA
Participants Wilkinson DS, Kenney JW, Sullivan C
ContactThomas J Gould     tgould@temple.edu     Lab web site
Part of a series: • nicotine acute and chronic study groups   (this project) Gould2
• nicotine withdrawal study group   see Gould3
AcknowledgementsFunding provided by NIH DA017949, DA024787, CA143187
Project type Phenotype strain survey data set
MPD identifiersGould2     MPD:471
Data changelog No updates/corrections.       Initial release date: 05/2013.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Mice: inbred   8 strains   ♂   age 8-12wks   8 experimental groups

Select table page: First Prev 1 - 10 / 16 (16) Next Last
Sort/
Pick
Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
Sample Size (Avg)
    Gould2 drug and metabolite quantification nicotine plasma nicotine   [ng/mL]  nicotine   47101     acute 0.09mg dose    chronic 6.3mg dose inbred 8 m 8-12wks N=10
    Gould2 drug and metabolite quantification nicotine plasma cotinine   [ng/mL]  cotinine   47105     acute 0.09mg dose    chronic 6.3mg dose inbred 8 m 8-12wks N=10
    Gould2 behavior observation nicotine chronic group, grooming   [n]  grooming   47111     control    nicotine inbred 8 m 8-12wks N=10
    Gould2 behavior observation nicotine chronic group, scratching   [n]  scratching   47113     control    nicotine inbred 8 m 8-12wks N=10
    Gould2 behavior observation nicotine chronic group, jumping   [n]  jumping   47115     control    nicotine inbred 8 m 8-12wks N=10
    Gould2 elevated plus maze nicotine chronic group, time in closed arms   [%]  EPM_pct_closed   47121     control    nicotine inbred 8 m 8-12wks N=9
    Gould2 elevated plus maze nicotine chronic group, time in open arms   [%]  EPM_pct_open   47123     control    nicotine inbred 8 m 8-12wks N=9
    Gould2 elevated plus maze nicotine chronic group, time in center   [%]  EPM_pct_center   47125     control    nicotine inbred 8 m 8-12wks N=9
    Gould2 fear conditioning test nicotine acute group, percent immobility in training chamber after first stimulus pairing   [%]  FC_immediate_acu   47131     dose (mg):    control    0.045    0.09    0.18 inbred 8 m 8-12wks N=11
    Gould2 fear conditioning test nicotine acute group, percent immobility in training chamber, 24h after fear conditioning   [%]  FC_context_acu   47136     dose (mg):    control    0.045    0.09    0.18 inbred 8 m 8-12wks N=11
    All boxes             To see more rows use the paging control at top.


  •   Or, add these measures to your collection.
       
  •     no folder
  •     put them in new folder