Gould2: Drug study: Effects of acute and chronic nicotine on fear conditioning and other behaviors in males of 8 inbred mouse strains (2011)

Portugal GS, Wilkinson DS, Kenney JW, Sullivan C, Gould TJ. Strain-dependent Effects of Acute, Chronic, and Withdrawal from Chronic Nicotine on Fear Conditioning. Behav Genet. 2012 Jan;42(1):133-50. Epub 2011 Aug 6.   PubMed 21822688  


       
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• Gould2 supplementary data
Participants George S Portugal       Columbia University New York, NY
Thomas J Gould       Temple University Philadelphia, PA
With: Wilkinson DS, Kenney JW, Sullivan C
ContactThomas J Gould     tgould@temple.edu     Lab web site
Part of a series: • nicotine acute and chronic study groups   (this project) Gould2
• nicotine withdrawal study group   see Gould3
AcknowledgementsFunding provided by NIH DA017949, DA024787, CA143187
Project type Phenotype strain survey data set
MPD identifiersGould2     MPD:471
Data changelog No updates/corrections.       Initial release date: 05/2013.
Formatted citation
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Acute group cohorts include saline controls and nicotine dose groups of 0.045, 0.09, and 0.18 mg/kg. Chronic group cohorts include saline controls and nicotine dose of 12 mg/kg/d administered for 14 days. Plasma assay and fear conditioning assays were done for both acute and chronic groups. EPM and somatic trait observation were done for the chronic group only.



Summary of procedures that were conducted
• drug and metabolite quantification Amount of nicotine and cotinine in blood plasma after nicotine doses. High and lower doses.
• behavior observation Observed measures of anxiety. Nicotine (high dose) vs. control. 20 min period.
• elevated plus maze Measures of anxiety. Nicotine (high dose) vs. control. 5 min test.
• fear conditioning test Contextual fear, cued fear. Nicotine (high and several lower doses) vs. control.
Mice: inbred   8 strains   ♂   age 8-12wks   8 cohorts